Effect of clonidine on experimental brain edema in the rat

1992 ◽  
Vol 37 (3-4) ◽  
pp. 268-272 ◽  
Author(s):  
B. Robert ◽  
J. Y. Petit ◽  
N. Grimaud ◽  
M. Jugé ◽  
L. Welin
Keyword(s):  
Brain Edema ◽  
Experimental Brain Edema

scholarly journals 87. Cerebrospinal Fluid Enzyme Studies in Experimental Brain Edema

1962 ◽  
Vol 4 (0) ◽  
pp. 207b-208
Author(s):  
S. AWAZU ◽  
M. EBARA ◽  
K. AKASHI ◽  
Y. KUSHIDA ◽  
S. MORIMOTO
Keyword(s):  
Cerebrospinal Fluid ◽  
Brain Edema ◽  
Experimental Brain Edema

The effects of glucosteroids on experimental cold-induced brain edema.

1971 ◽  
Vol 34 (4) ◽  
pp. 477-487 ◽  
Author(s):  
Robert E. Maxwell ◽  
Don M. Long ◽  
Lyle A. French
Keyword(s):  
Vascular Permeability ◽  
Brain Edema ◽  
Gray Matter ◽  
Dry Weight ◽  
Content Type ◽  
Beneficial Effects ◽  
Primary Reduction ◽  
Wet Weight ◽  
Experimental Brain Edema ◽  
Fine Print

✓ Although the beneficial effects of glucosteroids on brain edema are well documented and generally accepted clinically, investigations into their effects on experimental brain edema have been somewhat contradictory. In this study brain edema was produced by local cortical freezing in animals pretreated with glucosteroids and in untreated animals. Gross estimation of edema, wet weight-dry weight determination, and mechanical planimetry of areas of extravasated dye indicated a statistically significant reduction in edema of both white and gray matter at 24, 48, and 72 hours. Gross estimation of edema indicated a persisting effect with resolution of edema at 5 days in treated animals and from 7 to 12 days in untreated animals. These studies substantiate initial investigations and indicate a primary reduction in brain edema by glucosteroids. At least one of the effects of the glucosteroids appears to be reduction of the abnormal vascular permeability causing brain edema.

Acute dimethyl sulfoxide therapy in experimental brain edema

Neurosurgery ◽  
1981 ◽  
Vol 9 (1) ◽  
pp. 28???33 ◽  
Author(s):  
P E Camp ◽  
H E James ◽  
R Werner
Keyword(s):  
Dimethyl Sulfoxide ◽  
Brain Edema ◽  
Experimental Brain Edema

Acute dimethyl sulfoxide therapy in experimental brain edema

Neurosurgery ◽  
1982 ◽  
Vol 10 (3) ◽  
pp. 355???9 ◽  
Author(s):  
J Tsuruda ◽  
H E James ◽  
P E Camp ◽  
R Werner
Keyword(s):  
Dimethyl Sulfoxide ◽  
Brain Edema ◽  
Experimental Brain Edema

scholarly journals 62. Experimental Brain Edema using Intensed Ultrasoud, especially on Effects of Urea, 20% Mannitol, Adreno-cortico-Steroids and Chimotripsin

1965 ◽  
Vol 7 ◽  
pp. 197a-197a
Author(s):  
Hirotoshi NONAKA ◽  
Kazufumi ITO ◽  
Shigeru ISHIKAWA ◽  
Kunio YUKISHITA
Keyword(s):  
Brain Edema ◽  
Experimental Brain Edema

scholarly journals Trasylol on Experimental Brain Edema

1967 ◽  
Vol 9 ◽  
pp. 169a-169a
Author(s):  
Hideo AOKI ◽  
Tomiyasu EGAMI
Keyword(s):  
Brain Edema ◽  
Experimental Brain Edema

scholarly journals Effect of Methylprednisolone on Experimental Brain Edema in Magnetic Resonance Imaging

2020 ◽  
pp. 919-926
Author(s):  
P KOZLER ◽  
V HERYNEK ◽  
D MAREŠOVÁ ◽  
P PEREZ ◽  
L ŠEFC ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Brain Edema ◽  
Vasogenic Edema ◽  
Water Intoxication ◽  
Control Group ◽  
Resonance Imaging ◽  
Apparent Diffusion ◽  
Adc Values ◽  
Experimental Brain Edema

Magnetic resonance imaging has been used for evaluating of a brain edema in experimental animals to assess cytotoxic and vasogenic edema by the apparent diffusion coefficient (ADC) and T2 imaging. This paper brings information about the effectiveness of methylprednisolone (MP) on experimental brain edema. A total of 24 rats were divided into three groups of 8 animals each. Rats with cytotoxic/intracellular brain edema induced by water intoxication were assigned to the group WI. These rats also served as the additional control group CG when measured before the induction of edema. A third group (WIMP) was intraperitoneally administered with methylprednisolone 100 mg/kg during water intoxication treatment. The group WI+MP was injected with methylprednisolone 50 mg/kg into the carotid artery within two hours after the water intoxication treatment. We evaluated the results in four groups. Two control groups (CG, WI) and two experimental groups (WIMP, WI+MP). Rats were subjected to MR scanning 24 h after edema induction. We observed significantly increased ADC values in group WI in both evaluated areas – cortex and hippocampus, which proved the occurrence of experimental vasogenic edema, while ADC values in groups WIMP and WI+MP were not increased, indicating that the experimental edema was not developed and thus confirming the protective effect of MP.

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