Cell proliferation in the rat pituitary gland: A mechanism of control in prolactin cells

1979 ◽  
Vol 35 (5) ◽  
pp. 689-690 ◽  
Author(s):  
L. E. Kalbermann ◽  
I. Szijan ◽  
J. A. Burdman
Keyword(s):  
Cell Proliferation ◽  
Pituitary Gland ◽  
Prolactin Cells ◽  
Rat Pituitary

Effects of TRH, prolactin and TSH on cell proliferation in the intermediate lobe of the rat pituitary gland

1996 ◽  
Vol 148 (2) ◽  
pp. 193-196 ◽  
Author(s):  
T Pawełczyk ◽  
M Pawlikowski ◽  
J Kunert-Radek
Keyword(s):  
Cell Proliferation ◽  
Body Weight ◽  
Pituitary Gland ◽  
Anterior Lobe ◽  
Intermediate Lobe ◽  
Proliferating Cells ◽  
Rat Pituitary ◽  
Trh Analogues ◽  
Intermediate Pituitary Lobe ◽  
Significant Stimulatory Effect

Abstract The effect of TRH on cell proliferation in the anterior lobe of the pituitary is well known and documented. On the other hand, there are no data on the effects of TRH on the intermediate lobe of the pituitary gland. The aim of this study was to investigate the effect of TRH and its analogues (pGlu-His-Gly, pGlu-His-Gly-NH2) on cell proliferation in the intermediate pituitary lobe. The bromodeoxyuridine technique was used to detect the proliferating cells. It was found that TRH stimulated cell proliferation 24 h after a single injection at a dose of 100 μg/kg body weight. The TRH analogues did not exert any significant stimulatory effect either 12 h or 24 h after the injection. The second experiment was carried out to distinguish the probable mechanism of the action of TRH. The effects of TSH and prolactin (PRL) on intermediate lobe cell proliferation were examined. It was found that both PRL and TSH exerted a significant stimulatory effect 24 h after a single s.c. injection of PRL at a dose of 150 IU/kg body weight or TSH at a dose 20 IU/kg body weight. It therefore appears that the stimulatory effect of TRH on intermediate pituitary lobe cell proliferation is mediated by PRL and TSH. Journal of Endocrinology (1996) 148, 193–196

Stereotopography of the prolactin cells of the rat pituitary gland

1974 ◽  
Vol 30 (12) ◽  
pp. 1444-1446 ◽  
Author(s):  
J. B. Warchol ◽  
M. Shiino ◽  
E. G. Rennels
Keyword(s):  
Pituitary Gland ◽  
Prolactin Cells ◽  
Rat Pituitary

SYNTHESIS OF DNA IN OESTROGEN-INDUCED PITUITARY TUMOURS IN RATS: EFFECT OF BROMOCRIPTINE

1980 ◽  
Vol 87 (2) ◽  
pp. 221-224 ◽  
Author(s):  
L. E. KALBERMANN ◽  
G. A. MacHIAVELLI ◽  
A. F. DE NICOLA ◽  
L. S. WEISSENBERG ◽  
J. A. BURDMAN
Keyword(s):  
Cell Proliferation ◽  
Pituitary Gland ◽  
Dna Polymerase ◽  
Tritiated Thymidine ◽  
Pituitary Tumours ◽  
Considerable Decrease ◽  
Experimental Tumour ◽  
Intracellular Content ◽  
Rat Pituitary

Bromocriptine increased the concentration of prolactin in oestrogen-induced tumours of the rat pituitary gland. Prolactinaemia was significantly reduced and at the same time there was a considerable decrease in the weight of the tumour, in the incorporation of tritiated thymidine into DNA and in the activity of DNA polymerase a. The results suggested that the intracellular content of prolactin controls cell proliferation in this experimental tumour. A hypothalamic disorder is proposed as the primary cause of these tumours.

scholarly journals CircAgtpbp1 Acts as a Molecular Sponge of miR-543-5p to Regulate the Secretion of GH in Rat Pituitary Cells

Animals ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 558
Author(s):  
ZeWen Yu ◽  
WenZhi Ren ◽  
Tian Wang ◽  
WeiDi Zhang ◽  
ChangJiang Wang ◽  
...  
Keyword(s):  
Pituitary Gland ◽  
Inhibitory Effect ◽  
Pituitary Cells ◽  
Sequencing Analysis ◽  
Hormone Regulation ◽  
Gh Secretion ◽  
Qrt Pcr ◽  
Rat Pituitary ◽  
Rat Pituitary Cells

CircRNAs have been identified to be expressed differently and stably in numerous species and tissues, but their functions in growth hormone (GH) secretion are still largely unknown. In summary, we have revealed a circRNA-miRNA-mRNA network that may play a biological role in the rat pituitary gland. First, we verified the chromosome location information of circAgtpbp1 according to sequencing analysis. The circAgtpbp1 characteristics were authenticated through PCR, qRT–PCR, treating with RNase and fluorescent in situ hybridization (FISH). Second, we detected the expression pattern of circAgtpbp1 in the rat anterior pituitary by qRT–PCR. We also designed circAgtpbp1 siRNA and constructed overexpression plasmid to evaluate the effect of circAgtpbp1 function on GH secretion by qRT–PCR, ELISA and Western blot. CircAgtpbp1 is a stable, truly circular molecule. We found that circAgtpbp1 interacted with miR-543-5p and can regulate GH secretion in pituitary cells through a circAgtpbp1-miR-543-5p-GH axis. Overall, the evidence generated by our study suggests that circAgtpbp1 can act as a sponge of miR-543-5p to reduce the inhibitory effect of miR-543-5p on Gh1 and further promote GH secretion. These findings expand our existing knowledge on the mechanisms of hormone regulation in the pituitary gland.

Synaptophysin Immunoreactivity in the Aging Rat Pituitary Gland

1997 ◽  
Vol 43 (6) ◽  
pp. 561-564 ◽  
Author(s):  
L.C Saland ◽  
A Apodaca ◽  
D Ramirez ◽  
V Hernandez ◽  
J Gaddy ◽  
...  
Keyword(s):  
Pituitary Gland ◽  
Rat Pituitary ◽  
Aging Rat
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