Respiratory reflexes during anaphylactic bronchial asthma in guinea-pigs

1969 ◽  
Vol 25 (4) ◽  
pp. 368-369 ◽  
Author(s):  
E. A. Koller
Keyword(s):  
Bronchial Asthma ◽  
Guinea Pigs ◽  
Respiratory Reflexes

scholarly journals ENDOGENOUS NITRIC OXIDE INDUCES AIRFLOW LIMITATION IN BRONCHIAL ASTHMA OF GUINEA PIGS

1997 ◽  
Vol 75 ◽  
pp. 77
Author(s):  
H. IIJIMA ◽  
Y. UCHIDA ◽  
T. ENDO ◽  
A. NOMURA ◽  
M. SHIRATO ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Bronchial Asthma ◽  
Guinea Pigs ◽  
Airflow Limitation ◽  
Endogenous Nitric Oxide

Effects of Long Term High Oxygen Concentration Breathing on Defensive Respiratory Reflexes in Guinea-pigs

1996 ◽  
Vol 9 (5-6) ◽  
pp. 367-368 ◽  
Author(s):  
Jan Hanacek ◽  
Mariana Brozmanova ◽  
Milos Tatar ◽  
Danka Karcolova ◽  
Anna Strapkova ◽  
...  
Keyword(s):  
Oxygen Concentration ◽  
Guinea Pigs ◽  
High Oxygen ◽  
High Oxygen Concentration ◽  
Respiratory Reflexes

scholarly journals CHARACTERISTIC OF INDIVIDUAL INDICATORS OF ENDOGENOUS INTOXICATION IN THE EXPERIMENTAL ASTHMA DYNAMICS AND THEIR CORRECTION BY THIOTRIASOLIN

2016 ◽  
Vol 6 ◽  
pp. 52-56
Author(s):  
Marta Kolishetska
Keyword(s):  
Experimental Model ◽  
Bronchial Asthma ◽  
Guinea Pigs ◽  
Gradual Increase ◽  
Numerical Results ◽  
Static Method ◽  
Endogenous Intoxication ◽  
Direct Dependence ◽  
Positive Effect ◽  
Methods Numerical

The aim of this work was to find out the specifics of changes in endogenous intoxication, middle mass molecules (MMM) and erythrocyte intoxication index (EII) in the blood of animals for experimental asthma in different periods of its development and to correct them by thiotriazolin. Material and methods. Researches were carried out on 72 guinea-pigs (males), which were divided into 6 groups for 12 animals in each of them. The last sixth group included animals that were treated by thiotriazolin. The drug thiotriazolin rate of 100 mg / kg intramuscularly since 23rd day of the experiment for 10 days was administered in the animals of sixth group. Experimental model of bronchial asthma was restored on guinea-pigs by the V.I. Babych method (1979). In all groups of animals there were determined the middle mass molecules concentration in blood in the wave of 254 nm by I.A.Volchehorskiy, D.A.Dyatlova, E.I. Lvovska and others methods and EII by V.K. Kazymyrko V.I. Maltsev methods. Numerical results were adapted with static method using Student’s criteria. Results of the research. The highest level of endogenous intoxication in the blood was in the fifth group of guinea pigs with asthma (33rd day), indicating the direct dependence of the antigenic effect on their severity. Using of the thiotriazolin within 10 days (from 23rd to 33rd day) caused the decrease of the MMM254 concentration and EII in serum compared with a group of guinea pigs, that were not entered the medicine. It approved its treating effect. Conclusions. So, the research of middle mass molecules and erythrocyte intoxication index indicators in different periods of experimental asthma showed their gradual increase in serum of guinea pigs with the greatest severity in 33rd day of the experiment. It might indicate the development of endogenous intoxication animals. But the using of thiotriazolin caused the decreasing of these indicators. That gives a reason to state its positive effect on some markers of endogenous intoxication and feasibility of further researches.

scholarly journals The influence of thiotriazoline on the change of immune system in the blood of guinea-pigs under the conditions of development of experimental bronchial asthma

2015 ◽  
Vol 17 (2) ◽  
Author(s):  
M. S. Reheda ◽  
М. А. Kolishetska ◽  
V. R. Yurevych
Keyword(s):  
Immune System ◽  
T Lymphocytes ◽  
Blood Plasma ◽  
B Lymphocytes ◽  
Bronchial Asthma ◽  
Functional State ◽  
Immune Complexes ◽  
Guinea Pigs ◽  
Stimulation Of ◽  
Plasma Activity

<p>The aim of our research was to determine the character of the role and functional state of separate indexes<br />of the immune system in blood of guinea-pigs under the conditions of the development of experimental bronchial<br />asthma (BA ) and estimation of thiotriazoline influence on them. Decreasing of T-lymphocytes, stimulation of humoral<br />link of immunity, namely increasing of B-lymphocytes and immunoglobulins of A, M and G, elevation of circulatory<br />immune complexes and slump of complement blood plasma activity had been determined in this research. Immune<br />correcting action of thiotriazoline upon the pointed out indices in case of BA is revealed.</p>

scholarly journals Differential effects of airway afferent nerve subtypes on cough and respiration in anesthetized guinea pigs

2008 ◽  
Vol 295 (5) ◽  
pp. R1572-R1584 ◽  
Author(s):  
Yang-Ling Chou ◽  
Mark D. Scarupa ◽  
Nanako Mori ◽  
Brendan J. Canning
Keyword(s):  
Citric Acid ◽  
Hypertonic Saline ◽  
Guinea Pigs ◽  
Afferent Nerve ◽  
Vagal Afferents ◽  
C Fibers ◽  
Afferent Nerves ◽  
Nodose Ganglia ◽  
Opposing Effects ◽  
Respiratory Reflexes

The hypothesis that respiratory reflexes, such as cough, reflect the net and often opposing effects of activation of multiple afferent nerve subpopulations throughout the airways was evaluated. Laryngeal and tracheal mucosal challenge with either citric acid or mechanical probing reliably evoked coughing in anesthetized guinea pigs. No other stimulus reliably evoked coughing in these animals, regardless of route of administration and despite some profound effects on respiration. Selectively activating vagal C-fibers arising from the nodose ganglia with either adenosine or 2-methyl-5-HT evoked only tachypnea. Selectively activating vagal afferents arising from the jugular ganglia induced respiratory slowing and apnea. Nasal afferent nerve activation by capsaicin, citric acid, hypertonic saline, or histamine evoked only respiratory slowing. Histamine, which activates intrapulmonary rapidly adapting receptors but not airway or lung C-fibers or tracheal bronchial cough receptors induced bronchospasm and tachypnea, but no coughing. The results indicate that the reflexes initiated by stimuli thought to be selective for some afferent nerve subtypes will likely depend on the net and potentially opposing effects of multiple afferent nerve subpopulations throughout the airways. The data also provide further evidence that the afferent nerves regulating cough in anesthetized guinea pigs are distinct from either C-fibers or intrapulmonary rapidly adapting receptors.

scholarly journals A new bronchial asthma model using calcium ionophore A23187 in guinea pigs.

1989 ◽  
Vol 51 (3) ◽  
pp. 446-449 ◽  
Author(s):  
Miwa MISAWA ◽  
Toshihiko KAWAMURA ◽  
Kiyoteru TAKENOUCHI
Keyword(s):  
Bronchial Asthma ◽  
Guinea Pigs ◽  
Calcium Ionophore ◽  
Calcium Ionophore A23187 ◽  
Ionophore A23187 ◽  
Asthma Model
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