Cholinergic Muscarinic Receptor in the Nasal Mucosa of Guinea Pigs with Bronchial Asthma with and without Hypersensitive Nasal Symptoms

ORL ◽  
1985 ◽  
Vol 47 (6) ◽  
pp. 307-313 ◽  
Author(s):  
Akoyoshi Konno ◽  
Nobuhisa Terada ◽  
Yoshitaka Okamoto
Keyword(s):  
Muscarinic Receptor ◽  
Bronchial Asthma ◽  
Nasal Mucosa ◽  
Guinea Pigs ◽  
Nasal Symptoms

scholarly journals Cold bubble humidification of low-flow oxygen does not prevent acute changes in inflammation and oxidative stress at nasal mucosa

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Lauriana Alves Santana ◽  
Suellen Karoline Moreira Bezerra ◽  
Beatriz Mangueira Saraiva-Romanholo ◽  
Wellington Pereira Yamaguti ◽  
Iolanda de Fátima Lopes Calvo Tibério ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nasal Mucosa ◽  
Oxygen Therapy ◽  
Mucociliary Clearance ◽  
Nasal Cannula ◽  
Compressed Air ◽  
Low Flow ◽  
Cross Sectional ◽  
Nasal Symptoms ◽  
Nasal Inflammation

AbstractSome clinical situations require the use of oxygen therapy for a few hours without hypoxemia. However, there are no literature reports on the effects of acute oxygen therapy on the nasal mucosa. This study aimed to evaluate the acute effects of cold bubble humidification or dry oxygen on nasal Inflammation, oxidative stress, mucociliary clearance, and nasal symptoms. This is a randomized controlled cross-sectional study in which healthy subjects were randomly allocated into four groups: (1) CA + DRY (n = 8): individuals receiving dry compressed air; (2) OX + DRY (n = 8): individuals receiving dry oxygen therapy; (3) CA + HUMID (n = 7): individuals receiving cold bubbled humidified compressed air; (4) OX + HUMID (n = 8): individuals receiving cold bubbled humidified oxygen therapy. All groups received 3 L per minute (LPM) of the oxygen or compressed air for 1 h and were evaluated: total and differential cells in the nasal lavage fluid (NLF), exhaled nitric oxide (eNO), 8-iso-PGF2α levels, saccharin transit test, nasal symptoms, and humidity of nasal cannula and mucosa. Cold bubble humidification is not able to reduced nasal inflammation, eNO, oxidative stress, mucociliary clearance, and nasal mucosa moisture. However, subjects report improvement of nasal dryness symptoms (P < 0.05). In the conclusion, cold bubble humidification of low flow oxygen therapy via a nasal cannula did not produce any effect on the nasal mucosa and did not attenuate the oxidative stress caused by oxygen. However, it was able to improve nasal symptoms arising from the use of oxygen therapy.

scholarly journals ENDOGENOUS NITRIC OXIDE INDUCES AIRFLOW LIMITATION IN BRONCHIAL ASTHMA OF GUINEA PIGS

1997 ◽  
Vol 75 ◽  
pp. 77
Author(s):  
H. IIJIMA ◽  
Y. UCHIDA ◽  
T. ENDO ◽  
A. NOMURA ◽  
M. SHIRATO ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Bronchial Asthma ◽  
Guinea Pigs ◽  
Airflow Limitation ◽  
Endogenous Nitric Oxide

scholarly journals Autonomic nerve receptors in the allergic nasal mucosa in the human subjects and the sensitized guinea pigs.

1985 ◽  
Vol 88 (9) ◽  
pp. 1153-1161
Author(s):  
NOBUHISA TERADA ◽  
AKIYOSHI KONNO ◽  
YOSHITAKA OKAMOTO
Keyword(s):  
Nasal Mucosa ◽  
Guinea Pigs ◽  
Human Subjects ◽  
Autonomic Nerve

Effects of muscarinic receptor modulators on ocular biometry of guinea pigs

2014 ◽  
Vol 35 (1) ◽  
pp. 60-69 ◽  
Author(s):  
Fang Fang ◽  
Furong Huang ◽  
Ruozhong Xie ◽  
Cheng Li ◽  
Yin Liu ◽  
...  
Keyword(s):  
Muscarinic Receptor ◽  
Guinea Pigs ◽  
Ocular Biometry ◽  
Receptor Modulators
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