Idiotype vaccine for tumor by anti-idiotypic antibody prepared against anti-(bacillus Calmette Guèrin)BCG monoclonal antibody

1990 ◽  
Vol 31 (5) ◽  
pp. 273-277 ◽  
Author(s):  
Jin-ichi Sasaki ◽  
Takuma Tamagake ◽  
Satoshi Narita ◽  
Chowdhury Rafiqul Ahsan
Keyword(s):  
Monoclonal Antibody ◽  
Bacillus Calmette Guerin ◽  
Idiotype Vaccine ◽  
Idiotypic Antibody

877 ANTI-IL10-R1 MONOCLONAL ANTIBODY ENHANCES BACILLUS CALMETTE-GUERIN (BCG) INDUCED TH1 AND ANTI-BLADDER CANCER IMMUNE RESPONSES IN VITRO AND IN VIVO

2012 ◽  
Vol 187 (4S) ◽  
Author(s):  
Nathan A. Bockholt ◽  
Matthew J. Knudson ◽  
Jonathan R. Henning ◽  
Peter Weady ◽  
George J. Smith ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Bladder Cancer ◽  
Immune Responses ◽  
Bacillus Calmette Guerin

552 ANTI-IL10-R1 MONOCLONAL ANTIBODY WITH CONCOMITANT BACILLUS CALMETTE-GUERIN (BCG) PREVENTS METASTATIC BLADDER CANCER IN AN IN VIVO MOUSE MODEL

2012 ◽  
Vol 187 (4S) ◽  
Author(s):  
Eric J. Askeland ◽  
Mark R. Newton ◽  
Nathan A. Bockholt ◽  
Matthew J. Knudson ◽  
Jonathan R. Henning ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Bladder Cancer ◽  
Mouse Model ◽  
Bacillus Calmette Guerin ◽  
Metastatic Bladder Cancer

Anti-idiotypic antibodies bear the internal image of a human tumor antigen

Science ◽  
1986 ◽  
Vol 232 (4746) ◽  
pp. 100-102 ◽  
Author(s):  
D Herlyn ◽  
AH Ross ◽  
H Koprowski
Keyword(s):  
Monoclonal Antibody ◽  
Immune Response ◽  
Gastric Carcinoma ◽  
Tumor Antigen ◽  
Human Tumor ◽  
Internal Image ◽  
Tumor Associated Antigen ◽  
Idiotypic Antibody ◽  
Mouse Igg2a ◽  
Igg1 Isotype

Goat antibodies to idiotypes (anti-idiotypic antibodies; Ab2) that recognize an idiotype associated with the combining site of a BALB/c mouse IgG2a monoclonal antibody (Ab1) to human gastric carcinoma were used to immunize BALB/c mice and rabbits. A monoclonal anti-anti-idiotypic antibody (Ab3) of IgG1 isotype was obtained after immunization of mice. The Ab3 and the Ab1 showed identical binding specificities and bound with similar avidities to the same tumor antigen. The induction of Ab1-like Ab3 by Ab2 was not restricted to mice, since Ab3 could also be induced in rabbits. Both the mouse- and the rabbit-derived Ab3 bound the same gastrointestinal cancer-associated antigen as Ab1. These findings indicate that Ab2 induced the formation of antigen-specific Ab3, probably because it bears the internal image of the tumor-associated antigen. This Ab2 may therefore have potential for modulating the immune response of cancer patients to their tumors.

Studies of the interactions between the anticytokeratin 8 monoclonal antibody TS1, its antigen and its anti-idiotypic antibody αTS1

2003 ◽  
Vol 16 (3) ◽  
pp. 157-163 ◽  
Author(s):  
Ann Erlandsson ◽  
Patrik Holm ◽  
Amanda Ullén ◽  
Torgny Stigbrand ◽  
Birgitta E. Sundström
Keyword(s):  
Monoclonal Antibody ◽  
Idiotypic Antibody

Anti-idiotypic antibody Ab2/3H6 mimics the epitope of the neutralizing anti-HIV-1 monoclonal antibody 2F5

AIDS ◽  
2002 ◽  
Vol 16 (4) ◽  
pp. 667-668 ◽  
Author(s):  
Renate E. Kunert ◽  
Robert Weik ◽  
Boris Ferko ◽  
Gabriela Stiegler ◽  
Hermann Katinger
Keyword(s):  
Monoclonal Antibody ◽  
Idiotypic Antibody ◽  
Anti Hiv ◽  
Hiv 1
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