scholarly journals Anti-interleukin-10R1 monoclonal antibody in combination with bacillus Calmette-Guérin is protective against bladder cancer metastasis in a murine orthotopic tumour model and demonstrates systemic specific anti-tumour immunity

2014 ◽  
Vol 177 (1) ◽  
pp. 261-268 ◽  
Author(s):  
M. R. Newton ◽  
E. J. Askeland ◽  
E. D. Andresen ◽  
V. A. Chehval ◽  
X. Wang ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Bladder Cancer ◽  
Cancer Metastasis ◽  
Bacillus Calmette Guerin ◽  
Tumour Immunity ◽  
Tumour Model

877 ANTI-IL10-R1 MONOCLONAL ANTIBODY ENHANCES BACILLUS CALMETTE-GUERIN (BCG) INDUCED TH1 AND ANTI-BLADDER CANCER IMMUNE RESPONSES IN VITRO AND IN VIVO

2012 ◽  
Vol 187 (4S) ◽  
Author(s):  
Nathan A. Bockholt ◽  
Matthew J. Knudson ◽  
Jonathan R. Henning ◽  
Peter Weady ◽  
George J. Smith ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Bladder Cancer ◽  
Immune Responses ◽  
Bacillus Calmette Guerin

552 ANTI-IL10-R1 MONOCLONAL ANTIBODY WITH CONCOMITANT BACILLUS CALMETTE-GUERIN (BCG) PREVENTS METASTATIC BLADDER CANCER IN AN IN VIVO MOUSE MODEL

2012 ◽  
Vol 187 (4S) ◽  
Author(s):  
Eric J. Askeland ◽  
Mark R. Newton ◽  
Nathan A. Bockholt ◽  
Matthew J. Knudson ◽  
Jonathan R. Henning ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Bladder Cancer ◽  
Mouse Model ◽  
Bacillus Calmette Guerin ◽  
Metastatic Bladder Cancer

1570: Combined Mitomycin C and Hyperthermia (SYNERGO) for Patients with Superficial Bladder Cancer (SBC) after Bacillus Calmette-Guerin (BCG) Failure

2007 ◽  
Vol 177 (4S) ◽  
pp. 519-519
Author(s):  
Ofer Nativ ◽  
Renzo Colombo ◽  
Dov Engelstein ◽  
Ofer N. Gofrit ◽  
Thomas Akkad ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Mitomycin C ◽  
Superficial Bladder Cancer ◽  
Bacillus Calmette Guerin ◽  
Bcg Failure

scholarly journals Granulomatous Hepatitis Following Intra-Vesical Instillation of Bacillus Calmette–Guérin for Treatment of Bladder Cancer

2021 ◽  
Vol 13 (3) ◽  
pp. 611-618
Author(s):  
Elsa Alves Branco ◽  
Raquel Duro ◽  
Teresa Brito ◽  
António Sarmento
Keyword(s):  
Bladder Cancer ◽  
Hepatitis A ◽  
Adverse Reactions ◽  
Superficial Bladder Cancer ◽  
Rare Complication ◽  
Immunocompetent Patient ◽  
Clinical Suspicion ◽  
Bacillus Calmette Guerin ◽  
Granulomatous Hepatitis ◽  
Appropriate Treatment

Intra-vesical instillation of bacillus Calmette–Guérin (BCG) is an important treatment modality of superficial bladder cancer. It is usually well tolerated, although some adverse reactions can occur. One possible yet rare complication is granulomatous hepatitis, that is thought to be caused either by BCG infection or a hypersensitivity reaction to the bacillus. We present a case of a 79-year-old apparently immunocompetent patient who developed granulomatous hepatitis a few months after BCG administration for bladder cancer immunotherapy. It is important to notice that acid-fast smears and cultures are often negative, and these should not exclude diagnosis nor delay treatment. Our case highlights the importance of clinical suspicion and prompt initiation of appropriate treatment.

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