Serum levels of soluble interleukin-2 receptors in acute and chronic viral hepatitis

1989 ◽  
Vol 34 (10) ◽  
pp. 1559-1563 ◽  
Author(s):  
Alfredo Alberti ◽  
Liliana Chemello ◽  
Giovanna Fattovich ◽  
Patrizia Pontisso ◽  
Giampietro Semenzato ◽  
...  
Keyword(s):  
Viral Hepatitis ◽  
Interleukin 2 ◽  
Serum Levels ◽  
Chronic Viral Hepatitis

Serum levels of soluble CD30 in chronic viral hepatitis and alcoholic liver disease (ALD)

1998 ◽  
Vol 114 ◽  
pp. A1327
Author(s):  
P. Ravagnan ◽  
U. Lorenzoni ◽  
E.A. Galliani ◽  
ML. Tenderini ◽  
A. Popovic' ◽  
...  
Keyword(s):  
Liver Disease ◽  
Viral Hepatitis ◽  
Alcoholic Liver Disease ◽  
Serum Levels ◽  
Chronic Viral Hepatitis ◽  
Soluble Cd30

COMP serum levels: A new non-invasive biomarker of liver fibrosis in patients with chronic viral hepatitis

2017 ◽  
Vol 38 ◽  
pp. 83-88 ◽  
Author(s):  
Kalliopi Zachou ◽  
Stella Gabeta ◽  
Zakera Shums ◽  
Nikolaos K. Gatselis ◽  
George K. Koukoulis ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Viral Hepatitis ◽  
Serum Levels ◽  
Chronic Viral Hepatitis ◽  
Non Invasive

scholarly journals The role of serum bile acid profile in differentiation between nonalcoholic fatty liver disease and chronic viral hepatitis

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Azza Elsheashaey ◽  
Manar Obada ◽  
Eman Abdelsameea ◽  
Mohamed F. F. Bayomy ◽  
Hala El-Said
Keyword(s):  
Bile Acid ◽  
Viral Hepatitis ◽  
Bile Acids ◽  
Serum Levels ◽  
Chronic Viral Hepatitis ◽  
Serum Bile Acid ◽  
Nonalcoholic Fatty Liver ◽  
Bile Acid Level ◽  
The Mean

Abstract Background Bile acids are essential organic molecules synthesized from cholesterol in the liver. They have been utilized as indicators of hepatobiliary impairment because synthesis of BAs and their metabolism are influenced by liver diseases. We aimed to investigate the role of serum bile acid level and composition in differentiation between nonalcoholic fatty liver disease (NAFLD) and chronic viral hepatitis. An ultra-performance liquid chromatography coupled with mass spectrometry assay was used to measure the serum level of 14 bile acids in chronic viral hepatitis and NAFLD patients beside normal healthy control subjects. Results The mean serum levels of 11 out of the 14 bile acids (two primary, six conjugated, and three secondary) were significantly higher in viral hepatitis compared to control. Only 4 bile acids [2 primary, one glycine conjugated (GCDCA), and one secondary (LCA)] had statistically significant increase in their mean serum bile acid level in NAFLD compared to control. Comparing viral hepatitis group against NAFLD group revealed that the mean serum levels of five conjugated and one secondary bile acid (DCA) were significantly higher in viral hepatitis group. Receiver operating characteristic (ROC) curve analysis revealed that LCA had the best diagnostic performance for viral hepatitis followed by TCA and GCDCA. ROC curve for the combined three parameters had better sensitivity and specificity (70.55% and 94.87% respectively). Conclusion BA compositions including primary, secondary, and conjugated ones could differentiate between chronic viral hepatitis and NAFLD patients, and they might be potential distinguishing biomarkers for this purpose.

scholarly journals The significance of the detoxification system disorders in fibrogenesis in Chronic Viral Hepatitis С in children

2021 ◽  
Vol 20 (2) ◽  
pp. 38-43
Author(s):  
E. A. Galova ◽  
V. V. Krasnov
Keyword(s):  
Blood Serum ◽  
Viral Hepatitis ◽  
Serum Levels ◽  
Chronic Viral Hepatitis ◽  
Collagen Iv ◽  
Glutathione S Transferase ◽  
Average Mass ◽  
Viral Hepatitis C ◽  
High Level ◽  
The Relationship

Aim: to determine the relationship between of levels»protoxic» metabolites and «profibrotic» metabolites in the blood serum in children with chronic viral hepatitis C (HCV).Material and methods: the authors examined 54 children 14.0[6,0] years old with HCV. The blood serum levels of Molecules of average mass, Oligopeptides, Alcohol dehydrogenase, Glutathione-S-transferase, Ammonia, Arginase and Collagen IV have been studied.Results: A high level of «protoxic» metabolites in the blood serum was associated with a disorder of their elimination. The relationship with viral replication and biochemical hepatitis activity has not been identified. The collagen IV blood serum level was correlated with the accumulation and elimination of «protoxic» metabolites: R = 0.63, F = 5.19, p = 0.018.Conclusion: The level of collagen IV in the children's blood serum was associated with the accumulation and the elimination of «protoxic» metabolites.

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