Role of vasoactive intestinal peptide (VIP) in pathogenesis of ethanol-induced gastric mucosal damage in rats

1993 ◽  
Vol 38 (7) ◽  
pp. 1210-1219 ◽  
Author(s):  
Fanny Karmeli ◽  
Rami Eliakim ◽  
Elimelech Okon ◽  
Daniel Rachmilewitz
Keyword(s):  
Vasoactive Intestinal Peptide ◽  
Mucosal Damage ◽  
Gastric Mucosal Damage

Role of Lipoxygenases and the Lipoxin A4/Annexin 1 Receptor in Ischemia-Reperfusion-Induced Gastric Mucosal Damage in Rats

Pharmacology ◽  
2009 ◽  
Vol 84 (5) ◽  
pp. 294-299 ◽  
Author(s):  
Brigitta M. Peskar ◽  
Karlheinz Ehrlich ◽  
Rufina Schuligoi ◽  
Bernhard A. Peskar
Keyword(s):  
Ischemia Reperfusion ◽  
Mucosal Damage ◽  
Gastric Mucosal Damage ◽  
Lipoxin A4 ◽  
Annexin 1

scholarly journals Role of taurocholic acid in production of gastric mucosal damage after ingestion of aspirin.

BMJ ◽  
1975 ◽  
Vol 1 (5951) ◽  
pp. 183-185 ◽  
Author(s):  
K M Cochran ◽  
J F Mackenzie ◽  
R I Russell
Keyword(s):  
Mucosal Damage ◽  
Taurocholic Acid ◽  
Gastric Mucosal Damage

Role of nitric oxide in pathogenesis of gastric mucosal damage induced by compound in rats

1997 ◽  
Vol 91 (3-5) ◽  
pp. 131-138 ◽  
Author(s):  
T Yasuhiro ◽  
A Konaka ◽  
H Ukawa ◽  
S Kato ◽  
K Takeuchi
Keyword(s):  
Nitric Oxide ◽  
Mucosal Damage ◽  
Gastric Mucosal Damage

Effects of sucralfate on gastric prostaglandin and leukotriene synthesis: relationship to protective actions

1988 ◽  
Vol 66 (5) ◽  
pp. 666-670 ◽  
Author(s):  
John L. Wallace ◽  
Gerald P. Morris ◽  
Paul L. Beck ◽  
Todd E. Williamson ◽  
Guy R. Gingras
Keyword(s):  
Ex Vivo ◽  
Protective Action ◽  
Mucosal Damage ◽  
Gastric Mucosal Damage ◽  
Myeloperoxidase Activity ◽  
Protective Actions ◽  
Cyclooxygenase Activity ◽  
Chamber Model ◽  
Irritant Action

The mechanism of the protective actions of sucralfate against ethanol-induced gastric mucosal damage in the rat has been investigated. In particular, the role of prostaglandins as mediators of such protection was assessed. Oral administration of sucralfate at a dose causing a significant reduction of ethanol-induced gastric damage (500 mg/kg) did not significantly alter gastric 6-ketoprostaglandin F1α synthesis. Pretreatment with indomethacin at a dose that inhibited gastric cyclooxygenase activity by an average of 88% did not affect the protective actions of sucralfate. To further investigate the mechanism of action of sucralfate, an ex vivo gastric chamber model was used in which sucralfate could be applied to only one side of the mucosa. Sucralfate did not affect gastric prostaglandin synthesis, but did cause a significant increase in leukotriene C4 synthesis, a fall in transmucosal potential difference, and a significant decrease in gastric myeloperoxidase activity on the side exposed to sucralfate. These observations suggest that sucralfate has an irritant action on the mucosa. The release of mediators in response to such irritation may play an important role in the protective action of sucralfate. The present study supports the hypothesis that prostaglandins do not mediate the protection afforded by exposure to sucralfate.

scholarly journals Dexamethasone-induced gastric mucosal damage in the rat: possible role of platelet-activating factor

1992 ◽  
Vol 105 (4) ◽  
pp. 912-918 ◽  
Author(s):  
János G. Filep ◽  
Ferenc Hermán ◽  
Éva Földes-Filep ◽  
Ferenc Schneider ◽  
Pierre Braquet
Keyword(s):  
Platelet Activating Factor ◽  
Mucosal Damage ◽  
Gastric Mucosal Damage

scholarly journals The role of hydrogen sulfide in gastric mucosal damage

2019 ◽  
Vol 9 (2) ◽  
pp. 0 ◽  
Author(s):  
Fang Shen ◽  
Chong-Shun Zhao ◽  
Mei-Fen Shen ◽  
Zhong Wang ◽  
Gang Chen
Keyword(s):  
Hydrogen Sulfide ◽  
Mucosal Damage ◽  
Gastric Mucosal Damage
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