Role of Lipoxygenases and the Lipoxin A4/Annexin 1 Receptor in Ischemia-Reperfusion-Induced Gastric Mucosal Damage in Rats

Pharmacology ◽  
2009 ◽  
Vol 84 (5) ◽  
pp. 294-299 ◽  
Author(s):  
Brigitta M. Peskar ◽  
Karlheinz Ehrlich ◽  
Rufina Schuligoi ◽  
Bernhard A. Peskar
Keyword(s):  
Ischemia Reperfusion ◽  
Mucosal Damage ◽  
Gastric Mucosal Damage ◽  
Lipoxin A4 ◽  
Annexin 1

Role of ECL-cell histamine in acute gastric mucosal damage induced by ischemia-reperfusion

2001 ◽  
Vol 120 (5) ◽  
pp. A136
Author(s):  
Masayuki Kitano ◽  
Yosuke Kishimoto ◽  
Rolf Hakanson ◽  
Yoko Haenuki ◽  
Satoshi Onoda ◽  
...  
Keyword(s):  
Ischemia Reperfusion ◽  
Mucosal Damage ◽  
Gastric Mucosal Damage ◽  
Ecl Cell

Role of ECL-cell histamine in acute gastric mucosal damage induced by ischemia-reperfusion

2001 ◽  
Vol 120 (5) ◽  
pp. A136-A136
Author(s):  
M KITANO ◽  
Y KISHIMOTO ◽  
R HAKANSON ◽  
Y HAENUKI ◽  
S ONODA ◽  
...  
Keyword(s):  
Ischemia Reperfusion ◽  
Mucosal Damage ◽  
Gastric Mucosal Damage ◽  
Ecl Cell

scholarly journals Role of taurocholic acid in production of gastric mucosal damage after ingestion of aspirin.

BMJ ◽  
1975 ◽  
Vol 1 (5951) ◽  
pp. 183-185 ◽  
Author(s):  
K M Cochran ◽  
J F Mackenzie ◽  
R I Russell
Keyword(s):  
Mucosal Damage ◽  
Taurocholic Acid ◽  
Gastric Mucosal Damage

Leukocyte antiadhesive actions of annexin 1: ALXR- and FPR-related anti-inflammatory mechanisms

Blood ◽  
2003 ◽  
Vol 101 (10) ◽  
pp. 4140-4147 ◽  
Author(s):  
Felicity N. E. Gavins ◽  
Simon Yona ◽  
Ahmad M. Kamal ◽  
Roderick J. Flower ◽  
Mauro Perretti
Keyword(s):  
Ischemia Reperfusion ◽  
Human Neutrophils ◽  
Lipoxin A4 ◽  
Annexin 1 ◽  
Cell Incubation ◽  
High Concentrations ◽  
Adherent Leukocytes ◽  
Deficient Mice

Abstract Recent investigations conducted with human neutrophils have indicated an involvement for the receptor for formylated peptides, termed FPR, and its analog FPRL1 (or ALXR because it is the receptor for the endogenous ligand lipoxin A4) in the in vitro inhibitory actions of the glucocorticoid-regulated protein annexin 1 and its peptidomimetics. To translate these findings in in vivo settings, we have used an ischemia/reperfusion (I/R) procedure to promote leukocyte-endothelium interactions in the mouse mesenteric microcirculation. In naive mice, the annexin 1 mimetic peptide Ac2-26 (20 to 100 μg administered intravenously prior to reperfusion) abolished I/R-induced cell adhesion and emigration, but not cell rolling. In FPR-deficient mice, peptide Ac2-26 retained significant inhibitory actions (about 50% of the effects in naive mice), and these were blocked by an FPR antagonist, termed butyloxycarbonyl-Phe-Leu-Phe-Leu-Phe, or Boc2. In vitro, neutrophils taken from these animals could be activated at high concentrations of formyl-Met-Leu-Phe (30 μM; fMLP), and this effect was blocked by cell incubation with peptide Ac2-26 (66 μM) or Boc2 (100 μM). FPR-deficient neutrophils expressed ALXR mRNA and protein. Both ALXR agonists, lipoxin A4 and peptide Ac2-26, provoked detachment of adherent leukocytes in naive as well as in FPR-deficient mice, whereas the CXC chemokine KC or fMLP were inactive. The present findings demonstrate that endogenous regulatory autocoids such as lipoxin A4 and annexin 1–derived peptides function to disengage adherent cells during cell-cell interactions.

Role of vasoactive intestinal peptide (VIP) in pathogenesis of ethanol-induced gastric mucosal damage in rats

1993 ◽  
Vol 38 (7) ◽  
pp. 1210-1219 ◽  
Author(s):  
Fanny Karmeli ◽  
Rami Eliakim ◽  
Elimelech Okon ◽  
Daniel Rachmilewitz
Keyword(s):  
Vasoactive Intestinal Peptide ◽  
Mucosal Damage ◽  
Gastric Mucosal Damage

Role of nitric oxide in pathogenesis of gastric mucosal damage induced by compound in rats

1997 ◽  
Vol 91 (3-5) ◽  
pp. 131-138 ◽  
Author(s):  
T Yasuhiro ◽  
A Konaka ◽  
H Ukawa ◽  
S Kato ◽  
K Takeuchi
Keyword(s):  
Nitric Oxide ◽  
Mucosal Damage ◽  
Gastric Mucosal Damage
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