The effect of long-term feeding of Aroclor 1254 to female Rhesus monkeys on their polychlorinated biphenyl tissue levels

1989 ◽  
Vol 18 (6) ◽  
pp. 858-865 ◽  
Author(s):  
Jos Mes ◽  
Douglas L. Arnold ◽  
Fred Bryce ◽  
David J. Davies ◽  
Kazimierz Karpinski
Keyword(s):  
Rhesus Monkeys ◽  
Polychlorinated Biphenyl ◽  
Aroclor 1254 ◽  
Tissue Levels ◽  
Female Rhesus

scholarly journals Mammary Nodular Hyperplasia in Intact Rhesus Monkeys

1973 ◽  
Vol 10 (2) ◽  
pp. 130-134 ◽  
Author(s):  
L. W. Nelson ◽  
L. D. Shott
Keyword(s):  
Focal Nodular Hyperplasia ◽  
Rhesus Monkeys ◽  
Clinical Change ◽  
Control Female ◽  
Subcutaneous Nodules ◽  
Female Rhesus ◽  
Nodular Hyperplasia ◽  
Well Differentiated

Two control female Rhesus monkeys in long-term toxicity studies had multiple, palpable nodules in the breast regions. These subcutaneous nodules were 2–7 mm in diameter, firm, and freely movable. No progressive clinical change was observed during a follow-up of 17 or 20 months. Microscopically, one excised nodule consisted of proliferated acinar epithelial cells arranged in lobular patterns. The cells were well differentiated and presented no features of neoplasia. A diagnosis of focal nodular hyperplasia was compatible with the microscopie findings and the clinical follow-up of similar nodules.

Effect of long-term Centchroman treatment on plasma steroid and peptide hormones in female rhesus monkeys ()

Contraception ◽  
1985 ◽  
Vol 32 (3) ◽  
pp. 283-299 ◽  
Author(s):  
P.K. Nigam ◽  
B. Malaviya ◽  
S.R. Chowdhury ◽  
V.P. Kamboj ◽  
Harish Chandra
Keyword(s):  
Rhesus Monkeys ◽  
Peptide Hormones ◽  
Female Rhesus

Long-term effects of recombinant human growth hormone treatment on skeletal maturation and growth in female rhesus monkeys with normal pituitary function

1991 ◽  
Vol 130 (3) ◽  
pp. 435-441 ◽  
Author(s):  
M. E. Wilson ◽  
J. M. Tanner
Keyword(s):  
Growth Hormone ◽  
Rhesus Monkeys ◽  
Recombinant Human Growth Hormone ◽  
Human Growth ◽  
Term Treatment ◽  
Crown Rump Length ◽  
Long Term Treatment ◽  
Female Rhesus ◽  
Tibia Length

ABSTRACT Female rhesus monkeys (n = 5), having normal pituitary function, were treated for 50 months with recombinant human growth hormone (rhGH; 250 μg/kg) 3 days/week (Monday, Wednesday and Friday) and rates of growth were compared with a group of age-matched untreated females (n = 6). Treatment was initiated at 20 months of age, approximately 10 months before the expected age of menarche. Long-term treatment with rhGH accelerated bone maturation and increased the velocity of increase in crown–rump length, tibia length and body weight. The period of acceleration occurred coincident with the occurrence of spontaneous puberty. Body measurements remained larger in the treated females until growth ceased. Long-term rhGH treatment increased final adult crown–rump length by some 3%, with a slight increase in tibia length and body weight, without having any untoward effects on reproductive capacity or health. One treated animal exhibited higher estimates of antibodies to rhGH throughout the study period, and this female also had a smaller increment in crown–rump length than the other treated females. These data suggest that long-term treatment of normal-pituitary females with rhGH augments crown–rump growth without any untoward effects of health. Journal of Endocrinology (1991) 130, 435–441

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