Long-term persistence of polychlorinated biphenyl congeners in blood and liver and elevation of liver aminopyrine demethylase activity after a single high dose of aroclor 1254 to mice

1991 ◽  
Vol 10 (5) ◽  
pp. 681-690 ◽  
Author(s):  
Lucy M. Anderson ◽  
Dwayne Dixon ◽  
Lisa E. Beebe ◽  
Steven D. Fox ◽  
Haleem J. Issaq
Keyword(s):  
Polychlorinated Biphenyl ◽  
High Dose ◽  
Aroclor 1254 ◽  
Single High Dose ◽  
Demethylase Activity

Voluntarily exposure to a single, high dose of probiotic Escherichia coli results in prolonged colonisation

2014 ◽  
Vol 5 (4) ◽  
pp. 367-375 ◽  
Author(s):  
T.M. Wassenaar ◽  
C. Beimfohr ◽  
T. Geske ◽  
K. Zimmermann
Keyword(s):  
Escherichia Coli ◽  
Severe Side Effect ◽  
High Dose ◽  
Single High Dose ◽  
E Coli ◽  
Volunteer Study ◽  
Stool Analysis ◽  
Faecal Counts

The ability of probiotic Escherichia coli to colonise the human gut was determined in a volunteer study following national (German) regulations. Five persons voluntarily took a single, high dose of Symbioflor®2, which contains 6 different probiotic E. coli genotypes, to assess tolerance of the product, after which presence of E. coli in their faeces was tested for a follow-up period of 30 weeks. Intake of the product did not result in severe side effect in any of the individuals, though mild side effects were observed. Stool analysis showed that the probiotic E. coli had colonised all five persons for a period of 10 to 30 weeks (mean: 18.7 weeks, median: 25.7 weeks). In two individuals there was evidence of competition between host E. coli and probiotic E. coli, while in two others total E. coli levels increased persistently with at least a factor of 10 as a result of the received dose. In one individual, who had lacked detectable levels of faecal E. coli at the start of the post-authorisation safety study, long-term colonisation was established, first by probiotic E. coli exclusively, which were later replaced by host E. coli strains. In four out of five individuals, total E. coli faecal counts were higher on average than at the start of the experiment, while in none total levels exceeded 5×107 cfu/g. When the specific genotypes of the 6 probiotic E. coli were analysed, it was found that one and the same common genotype was responsible for prolonged colonisation in all five individuals.

Combined consumption of a single high-dose vitamin A supplement with provision of vitamin A fortified oil to households maintains adequate milk retinol concentrations for 6 months in lactating Moroccan women

2020 ◽  
Vol 45 (3) ◽  
pp. 275-282 ◽  
Author(s):  
Naima Atalhi ◽  
Asmaa El Hamdouchi ◽  
Amina Barkat ◽  
Khalid Elkari ◽  
Abdeslam Hamrani ◽  
...  
Keyword(s):  
Vitamin A ◽  
Low Income ◽  
Postpartum Women ◽  
High Dose ◽  
Serum Retinol ◽  
Single High Dose ◽  
Moroccan Women ◽  
Serum Retinol Concentration ◽  
To Receive

In Morocco, postpartum women systematically receive a single, high dose of vitamin A (VA; 200 000 IU) within the first month of giving birth and vegetable oil is fortified to increase the VA intake. The efficacy of this combined approach of supplementation and fortification for increasing maternal VA status during lactation is not known. The purpose of the study is to evaluate the effect of postpartum high dose VA supplementation and provision of VA fortified oil for household consumption on plasma and milk retinol concentrations of lactating Moroccan women during the first 6 months after giving birth. Postpartum women aged 19–40 years received a VA supplement and thereafter were randomly assigned to one of two groups to receive weekly vitamin A fortified oil (FO) or non-fortified oil (NFO) for 6 months. Serum retinol concentration was higher in the FO group than in the NFO group at 6 months after giving birth (p < 0.0001). Milk retinol per gram fat at baseline did not differ by group; by 3 months after giving birth, milk retinol per gram fat was higher in the FO group than in the NFO group (p = 0.02) and remained higher throughout the 6 months (p < 0.0001). The combination of supplementation and fortification has a more sustained impact on milk retinol concentrations than supplementation alone, which did not have a sustained impact on milk VA concentrations. The fortification approach seems to be more effective for maintaining adequate milk VA concentrations among lactating Moroccan women. Fortification seems to be a long-term solution for the problem of VA deficiency, especially among women in low-income communities.

Long-term follow-up for brain metastases treated by percutaneous stereotactic single high-dose irradiation

Cancer ◽  
1993 ◽  
Vol 71 (4) ◽  
pp. 1353-1361 ◽  
Author(s):  
Rita Engenhart ◽  
Bernhard N. Kimmig ◽  
Karl-Heinz Höver ◽  
Bernd Wowra ◽  
Jürgen Romahn ◽  
...  
Keyword(s):  
Brain Metastases ◽  
High Dose ◽  
Single High Dose ◽  
Dose Irradiation ◽  
Long Term Follow Up

scholarly journals 30 GY SINGLE HIGH DOSE STEREOTACTIC BODY RADIOTHERAPY IN THE TREATMENT OF PRIMARY LUNG TUMORS: LONG TERM RESULTS

CHEST Journal ◽  
2020 ◽  
Vol 157 (6) ◽  
pp. A259
Author(s):  
L. Nicosia ◽  
C. Reverberi ◽  
L. Agolli ◽  
V. De Sanctis ◽  
M. Valeriani ◽  
...  
Keyword(s):  
Stereotactic Body Radiotherapy ◽  
Lung Tumors ◽  
Long Term Results ◽  
High Dose ◽  
Single High Dose ◽  
Primary Lung Tumors

The effect of long-term feeding of Aroclor 1254 to female Rhesus monkeys on their polychlorinated biphenyl tissue levels

1989 ◽  
Vol 18 (6) ◽  
pp. 858-865 ◽  
Author(s):  
Jos Mes ◽  
Douglas L. Arnold ◽  
Fred Bryce ◽  
David J. Davies ◽  
Kazimierz Karpinski
Keyword(s):  
Rhesus Monkeys ◽  
Polychlorinated Biphenyl ◽  
Aroclor 1254 ◽  
Tissue Levels ◽  
Female Rhesus
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