Postmortem tissue levels of polychlorinated biphenyls in female rhesus monkeys after more than six years of daily dosing with Aroclor� 1254 and in their non-dosed offspring

1995 ◽  
Vol 29 (1) ◽  
pp. 69-76 ◽  
Author(s):  
J. Mes ◽  
D. L. Arnold ◽  
F. Bryce
1989 ◽  
Vol 18 (6) ◽  
pp. 858-865 ◽  
Author(s):  
Jos Mes ◽  
Douglas L. Arnold ◽  
Fred Bryce ◽  
David J. Davies ◽  
Kazimierz Karpinski

Author(s):  
Allen D. Uhler ◽  
Jeffery H. Hardenstine ◽  
Deborah A. Edwards ◽  
Guilherme R. Lotufo

AbstractPolychlorinated biphenyls (PCBs) were added to certain marine vessel bottom paints as a plasticizer to improve the adhesion and durability of the paint. The most common PCB formulation used to amend such paints was Aroclor 1254. Fugitive Aroclor-containing paint chips generated from vessel maintenance and repair operations represent a potential source of PCB contamination to sediments. Limited published studies indicate that Aroclor-containing paint is largely inert and exhibits low PCB leaching into water; however, the rate and degree of leaching of PCBs from paint chips have not been directly studied. This laboratory-based study evaluated the rate and extent of leaching of PCBs from paint chips into freshwater. The results of this investigation demonstrate that the rate of PCB dissolution from paint chips decreased rapidly and exponentially over time. Based on this study, it is estimated that the rate of leaching of PCBs from paint chips would cease after approximately 3 years of exposure to water. When all leachable PCBs were exhausted, it is estimated that less than 1% of the mass of PCBs in the paint chips was amenable to dissolution. The results of this experiment suggest that Aroclor-containing paint chips found in sediments are likely short-term sources of dissolved-phase PCB to pore or surface waters and that the majority of the PCBs in paint chips remain in the paint matrix and unavailable for partitioning into water. Graphic Abstract


2000 ◽  
Vol 19 (5) ◽  
pp. 1311-1316 ◽  
Author(s):  
Patricia E. Ganey ◽  
John F. Quensen ◽  
Mahmoud A. Mousa ◽  
Stephen A. Boyd ◽  
Margaret A. Wagner ◽  
...  

Endocrinology ◽  
1986 ◽  
Vol 119 (4) ◽  
pp. 1625-1631 ◽  
Author(s):  
SAMUEL A. SHOLL ◽  
STEVEN M. POMERANTZ

1971 ◽  
Vol 51 (3) ◽  
pp. 575-588 ◽  
Author(s):  
B. J. EVERITT ◽  
J. HERBERT

SUMMARY The effect of dexamethasone, given either alone or together with testosterone propionate or androstenedione, was studied in nine female rhesus monkeys (paired with three males) by making quantitative observations on behaviour in the laboratory. Dexamethasone (0·5 mg/kg/day) given to oestrogen-treated ovariectomized female monkeys made them sexually unreceptive, and there was an associated decline in the level of the male's mounting activity. Testosterone propionate (100 or 200 μg/day) reversed completely the effects of dexamethasone on sexual behaviour. Androstenedione (100, 200 or 400 μg/day) had similar, but less marked, effects whereas cortisol (10 mg/day) or progesterone (100, 200 or 500 μg/day) were ineffective. Treating a female with testosterone prevented dexamethasone from reducing sexual receptivity. Parallel determinations of urinary free cortisol showed that the dexamethasone had suppressed the secretory activity of the adrenal cortex. There were no consistent changes, under any treatment, in the females' vaginal epithelia, sexual skins or clitorides, or in their water or electrolyte metabolism. These findings indicate that adrenal androgens regulate sexual receptivity in these female primates, probably by an action on the central nervous system.


Chemosphere ◽  
1990 ◽  
Vol 20 (7-9) ◽  
pp. 1199-1202 ◽  
Author(s):  
R.E. Bowman ◽  
H.Y. Tong ◽  
M.L. Gross ◽  
S.J. Monson ◽  
N.C.A. Weerasinghe

1985 ◽  
Vol 108 (1) ◽  
pp. 31-35
Author(s):  
J. G. Herndon ◽  
M. S. Blank ◽  
D. R. Mann ◽  
D. C. Collins ◽  
J.J. Turner

Abstract. Suppression of luteinizing hormone (LH) by sc implanted oestradiol-17ß (E2) pellets was examined in 4 ovariectomized female rhesus monkeys during the breeding season, the non-breeding season and during the transition between the breeding and non-breeding season. Immunoreactive LH was suppressed to 58, 78 and 75% of untreated levels for the respective seasonal conditions. Bioactive LH was suppressed to 29, 49 and 33% of baseline. Bioactive LH (determined by testoster-one release from rat interstital cells) was significantly correlated (r = 0.84) with immunoactive LH from the same samples. It is concluded that E2 treatment of ovariectomized female rhesus monkeys results in suppressed levels of LH, regardless of the time of year.


Sign in / Sign up

Export Citation Format

Share Document