Kinetics of mast cells, eosinophils and phospholipase B activity in the spontaneous-cure response of two strains of mice (rapid and slow responder) to the cestodeHymenolepis nana

1989 ◽  
Vol 75 (6) ◽  
pp. 465-469 ◽  
Author(s):  
G. Bortoletti ◽  
F. Gabriele ◽  
C. Palmas
Keyword(s):  
Mast Cells ◽  
Spontaneous Cure ◽  
Phospholipase B ◽  
Kinetics Of ◽  
Slow Responder

Kinetics of Fc.epsilon.RI Dimer Formation by Specific Monoclonal Antibodies on Mast Cells

Biochemistry ◽  
1994 ◽  
Vol 33 (29) ◽  
pp. 8813-8825 ◽  
Author(s):  
Reinhard Schweitzer-Stenner ◽  
Enrique Ortega ◽  
Israel Pecht
Keyword(s):  
Monoclonal Antibodies ◽  
Mast Cells ◽  
Dimer Formation ◽  
Kinetics Of

Kinetics of protein phosphorylation and mediator secretion following antigen challenge of mast cells sensitized with monoclonal IgE or with reaginic serum

1997 ◽  
Vol 46 (13) ◽  
pp. 21-22
Author(s):  
C. Guérin-Marchand ◽  
T. Michon ◽  
B. Kolago ◽  
F. Marchand ◽  
A. Weyer ◽  
...  
Keyword(s):  
Mast Cells ◽  
Protein Phosphorylation ◽  
Antigen Challenge ◽  
Mediator Secretion ◽  
Kinetics Of

Kinetics of oxygen metabolism indices in the course of histamine secretion from rat mast cells

1990 ◽  
Vol 30 (1-2) ◽  
pp. 85-88 ◽  
Author(s):  
I. S. Gushchin ◽  
I. M. Petyaev ◽  
O. R. Tsinkalovsky
Keyword(s):  
Mast Cells ◽  
Oxygen Metabolism ◽  
Histamine Secretion ◽  
Kinetics Of ◽  
Rat Mast Cells

scholarly journals In vivo kinetics of eosinophils and mast cells in experimental murine Schistosomiasis

1987 ◽  
Vol 82 (suppl 4) ◽  
pp. 67-76 ◽  
Author(s):  
H. L. Lenzi ◽  
A. C. L. Sobral ◽  
J. A. Lenzi
Keyword(s):  
Mast Cells ◽  
In Vivo Kinetics ◽  
Kinetics Of

Extracellular effect of calcium on compound 48/80 stimulated mast cells

1983 ◽  
Vol 61 (1) ◽  
pp. 79-84 ◽  
Author(s):  
Narendranath S. Ranadive ◽  
Rubina Lewis
Keyword(s):  
Mast Cells ◽  
Histamine Release ◽  
High Concentration ◽  
Extracellular Concentration ◽  
Exchangeable Ca ◽  
Intracellular Ca ◽  
Kinetics Of ◽  
Rat Mast Cells

The effects of changes in the extracellular concentration of calcium on activation of rat mast cells by compound 48/80 were studied. The intracellular exchangeable Ca2+ pools at various concentrations of extracellular Ca2+ were determined by equilibration of the cells with 45Ca2+. The cells stimulated by compound 48/80 in the presence of 2.5 μM and 1.6 mM extracellular Ca2+ released comparable amounts of histamine. However, the intracellular Ca2+ pool was doubled in 2.5 μM Ca2+ and was increased sixfold in 1.6 mM Ca2+. In 14.4 mM extracellular Ca2+, there was neither release of histamine nor uptake of Ca2+ which suggested an impairment in activation. The kinetics of Ca2+ influx in the presence of 2.5 μM Ca2+ did not reveal intracellular mobilization of calcium. The cells activated in 1.6 mM Ca2+ at 0 °C when allowed to stand in 14.4 mM extracellular Ca2+ released decreased amounts of histamine upon warming to 37 °C. The inhibition of the release progressively increased with time of standing at 0 °C. The decrease in histamine release was not seen with the cells standing in 1.6 mM Ca2+ at 0 °C. The effect of 14.4 mM Ca2+ added prior to the challenge with compound 48/80 did not depend on the time of incubation. The data presented in this paper suggest that the high concentration of Ca2+ inhibits the histamine release from mast cells by interfering with membrane-associated phenomena.

scholarly journals Relationship between arachidonate generation and exocytosis in permeabilized mast cells

1990 ◽  
Vol 266 (1) ◽  
pp. 157-163 ◽  
Author(s):  
Y Churcher ◽  
D Allan ◽  
B D Gomperts
Keyword(s):  
Mast Cells ◽  
Phospholipase A2 ◽  
Guanine Nucleotide ◽  
Streptolysin O ◽  
General Similarity ◽  
Arachidonate Release ◽  
Kinetics Of ◽  
Rat Mast Cells

Using rat mast cells permeabilized with streptolysin O we show that release of arachidonate generally occurs under similar but not identical conditions to those that cause exocytosis of beta-N-acetylglucosaminidase (hexosaminidase). Thus, hexosaminidase secretion and arachidonate release both require provision of Ca2+ together with a guanine nucleotide but exocytosis occurs at lower concentrations of both effectors. The kinetics of both processes are similar, with a delay in onset only when ATP is present. Arachidonate release occurs largely from a pool of arachidonyl phosphatidylcholine which appears to represent less than 1% of the total phosphatidylcholine of the cells. Despite the general similarity of the conditions causing exocytosis and arachidonate release, our results show that under some circumstances it is possible to obtain exocytosis without measurable release of arachidonate and that therefore phospholipase A2 activation is not an essential precursor of secretion.

Intestinal mast cells and eosinophils in relation to Strongyloides ratti adult expulsion from the small and large intestines of rats

Parasitology ◽  
2013 ◽  
Vol 140 (5) ◽  
pp. 626-631 ◽  
Author(s):  
Y. SHINTOKU ◽  
T. KADOSAKA ◽  
E. KIMURA ◽  
H. TAKAGI ◽  
S. KONDO ◽  
...  
Keyword(s):  
Small Intestine ◽  
Mast Cells ◽  
Post Infection ◽  
Crucial Role ◽  
The Other ◽  
Mucosal Mast Cells ◽  
Intestinal Parasitism ◽  
Small Intestines ◽  
Kinetics Of ◽  
Stimulation Of

SUMMARYMucosal mast cells (MMC) play a crucial role in the expulsion of Strongyloides ratti adults from the small intestine of mice. We reported the large intestinal parasitism of S. ratti in rats, and there has been no report on MMC in the large intestine of the natural host. We studied kinetics of MMC, together with eosinophils, in the upper and lower small intestines, caecum and colon of infected rats. Two distinct phases of mastocytosis were revealed: one in the upper small intestine triggered by stimulation of ‘ordinary’ adults, and the other in the colon stimulated by ‘immune-resistant’ adults that started parasitizing the colon around 19 days post-infection. In all 4 intestinal sites, the MMC peaks were observed 5–7 days after the number of adult worms became the maximum and the height of MMC peaks appeared to be dependent on the number of parasitic adults, suggesting an important role played by worms themselves in the MMC buildup.

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