Kinetics of oxygen metabolism indices in the course of histamine secretion from rat mast cells

1990 ◽  
Vol 30 (1-2) ◽  
pp. 85-88 ◽  
Author(s):  
I. S. Gushchin ◽  
I. M. Petyaev ◽  
O. R. Tsinkalovsky
Keyword(s):  
Mast Cells ◽  
Oxygen Metabolism ◽  
Histamine Secretion ◽  
Kinetics Of ◽  
Rat Mast Cells

Effect of flavone inhibitors of transport ATPases on histamine secretion from rat mast cells

Nature ◽  
1977 ◽  
Vol 265 (5595) ◽  
pp. 635-636 ◽  
Author(s):  
C. M. S. FEWTRELL ◽  
B. D. GOMPERTS
Keyword(s):  
Mast Cells ◽  
Histamine Secretion ◽  
Transport Atpases ◽  
Rat Mast Cells

Extracellular effect of calcium on compound 48/80 stimulated mast cells

1983 ◽  
Vol 61 (1) ◽  
pp. 79-84 ◽  
Author(s):  
Narendranath S. Ranadive ◽  
Rubina Lewis
Keyword(s):  
Mast Cells ◽  
Histamine Release ◽  
High Concentration ◽  
Extracellular Concentration ◽  
Exchangeable Ca ◽  
Intracellular Ca ◽  
Kinetics Of ◽  
Rat Mast Cells

The effects of changes in the extracellular concentration of calcium on activation of rat mast cells by compound 48/80 were studied. The intracellular exchangeable Ca2+ pools at various concentrations of extracellular Ca2+ were determined by equilibration of the cells with 45Ca2+. The cells stimulated by compound 48/80 in the presence of 2.5 μM and 1.6 mM extracellular Ca2+ released comparable amounts of histamine. However, the intracellular Ca2+ pool was doubled in 2.5 μM Ca2+ and was increased sixfold in 1.6 mM Ca2+. In 14.4 mM extracellular Ca2+, there was neither release of histamine nor uptake of Ca2+ which suggested an impairment in activation. The kinetics of Ca2+ influx in the presence of 2.5 μM Ca2+ did not reveal intracellular mobilization of calcium. The cells activated in 1.6 mM Ca2+ at 0 °C when allowed to stand in 14.4 mM extracellular Ca2+ released decreased amounts of histamine upon warming to 37 °C. The inhibition of the release progressively increased with time of standing at 0 °C. The decrease in histamine release was not seen with the cells standing in 1.6 mM Ca2+ at 0 °C. The effect of 14.4 mM Ca2+ added prior to the challenge with compound 48/80 did not depend on the time of incubation. The data presented in this paper suggest that the high concentration of Ca2+ inhibits the histamine release from mast cells by interfering with membrane-associated phenomena.

scholarly journals Inhibitory effects of caffeine and other methylxanthines on Ca2+ mobilization and histamine secretion independent of cAMP in rat mast cells.

1995 ◽  
Vol 67 ◽  
pp. 289
Author(s):  
Hiroki Teraoka ◽  
Hiroe Akiba ◽  
Ryo Takai ◽  
Tetsuro Taneike ◽  
Takeo Hirapa ◽  
...  
Keyword(s):  
Mast Cells ◽  
Inhibitory Effects ◽  
Histamine Secretion ◽  
Rat Mast Cells

scholarly journals Neurotensin stimulates exocytotic histamine secretion from rat mast cells and elevates plasma histamine levels.

1982 ◽  
Vol 323 (1) ◽  
pp. 403-414 ◽  
Author(s):  
R Carraway ◽  
D E Cochrane ◽  
J B Lansman ◽  
S E Leeman ◽  
B M Paterson ◽  
...  
Keyword(s):  
Mast Cells ◽  
Plasma Histamine ◽  
Histamine Secretion ◽  
Rat Mast Cells
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