Parietal cell ultrastructure in relation to location along the fundic gland

1979 ◽  
Vol 88 (2) ◽  
pp. 932-935
Author(s):  
E. I. Ryabchikova ◽  
M. S. Vinogradova
Keyword(s):  
Parietal Cell ◽  
Cell Ultrastructure ◽  
Fundic Gland

Fundic Gland Polyp With Parietal Cell Vacuolation Mimicking Signet Ring Cell Carcinoma

2021 ◽  
pp. 106689692199418
Author(s):  
John D. Coyne ◽  
S. Thampy
Keyword(s):  
Proton Pump Inhibitor ◽  
Cell Carcinoma ◽  
Parietal Cell ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Fundic Gland ◽  
Fundic Gland Polyp ◽  
Signet Ring ◽  
Ring Cell

Pseudo-signet ring parietal cell vacuolation has been described as a mimic of invasive signet ring cell carcinoma. Moreover, signet ring cell carcinoma has been described in a fundic gland polyp. This case demonstrates parietal cell vacuolation in a fundic gland polyp in a patient on a long-term proton pump inhibitor.

scholarly journals GASTRIC FUNDIC GLAND POLYPS: CAN HISTOLOGY BE USEFUL TO PREDICT PROTON PUMP INHIBITORS USE?

2018 ◽  
Vol 55 (4) ◽  
pp. 380-384
Author(s):  
Hugo Leite de Farias BRITO ◽  
Cynthia BARROS ◽  
Marcelle Vieira FREIRE ◽  
Miraldo Nascimento da SILVA FILHO ◽  
Tereza Virgínia NASCIMENTO
Keyword(s):  
Proton Pump Inhibitor ◽  
Proton Pump Inhibitors ◽  
Parietal Cell ◽  
Proton Pump ◽  
Proton Pump Inhibitor Therapy ◽  
Inhibitor Therapy ◽  
Fundic Gland ◽  
Acid Therapy ◽  
Fundic Gland Polyps ◽  
Two Samples

ABSTRACT BACKGROUND: Fundic gland polyps allegedly increased in frequency in recent decades, and had attracted great attention due to possible association with prolonged proton pump inhibitor therapy. Prolonged use of this drug could cause parietal cell hyperplasia, obstruction of glandular lumen and cystic dilation of the gland. OBJECTIVE: This study aims to analyze clinical and pathological features of fundic gland polyps in patients with and without proton pump inhibitor therapy in a selected population from Brazil. METHODS: It was selected a sample of 101 Brazilian patients (78 females and 23 males), from a five years retrospective search of the files from a private pathology laboratory. The patients had an average age of 57 years and we included patients with a histological diagnosis of fundic gland polyp. The clinical data were obtained from their files and all histological slides were reviewed and examined with hematoxylin and eosin (HE) and Giemsa. RESULTS: Information about the use or non-use of proton pump inhibitors (PPI) was obtained in 84 patient files. In 17 cases we could not determine if PPI were used or not. Among those in which the information was available, a positive history of anti-acid therapy was observed in 63 (75.0%) patients. Parietal cell hypertrophy/hyperplasia and parietal cell protrusions were detected in most slides. Histological findings were identical in PPI users and PPI negative patients. Helicobacter pylori infection was detected in just two samples. Epithelial dysplasia or adenocarcinoma were not observed in our cases. Histopathological analysis of fundic gland polyps could not distinguish between PPI and non-PPI related cases. Parietal cell cytoplasmic protrusions, an alleged marker of prolonged acid suppression therapy, was detected in both groups. CONCLUSION: Histological features could not discriminate anti-acid therapy related fundic glands polyps in our patients.

Parietal cell protrusions and fundic gland cysts during omeprazole maintenance treatment

2000 ◽  
Vol 31 (6) ◽  
pp. 684-690 ◽  
Author(s):  
A CATS ◽  
B EDSCHENK ◽  
E BLOEMENA ◽  
R ROOSENDAAL ◽  
J LINDEMAN ◽  
...  
Keyword(s):  
Parietal Cell ◽  
Maintenance Treatment ◽  
Fundic Gland

Effect of pentagastrin on parietal cell ultrastructure in glucagon-pretreated subjects

1982 ◽  
Vol 27 (5) ◽  
pp. 394-400
Author(s):  
Kevin J. Ivey ◽  
Andrzej Tarnawski ◽  
William J. Krause ◽  
Jerzy Stachura ◽  
Debra Sherman ◽  
...  
Keyword(s):  
Parietal Cell ◽  
Cell Ultrastructure

Parietal cell protrusions with fundic gland cysts and fundic gland polyps: Are they related or simply similar but distinguishable?

2000 ◽  
Vol 31 (12) ◽  
pp. 1536-1537 ◽  
Author(s):  
Paolo Declich ◽  
Stefano Bellone ◽  
Monica Porcellati ◽  
Aurora Bortoli ◽  
Claudio Gozzini ◽  
...  
Keyword(s):  
Parietal Cell ◽  
Fundic Gland ◽  
Fundic Gland Polyps

Letters to the Editor. Parietal cell hyperplasia with deep cystic dilations: a lesion closely mimicking fundic gland polyps

2000 ◽  
Vol 95 (2) ◽  
pp. 566-568 ◽  
Author(s):  
Paolo Declich ◽  
Luciana Ambrosiani ◽  
Stefano Bellone ◽  
Enrico Tavani ◽  
Roberta Grassini ◽  
...  
Keyword(s):  
Parietal Cell ◽  
Fundic Gland ◽  
Letters To The Editor ◽  
Cell Hyperplasia ◽  
Fundic Gland Polyps
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