Parietal cell protrusions and fundic gland cysts during omeprazole maintenance treatment

2000 ◽  
Vol 31 (6) ◽  
pp. 684-690 ◽  
Author(s):  
A CATS ◽  
B EDSCHENK ◽  
E BLOEMENA ◽  
R ROOSENDAAL ◽  
J LINDEMAN ◽  
...  
Keyword(s):  
Parietal Cell ◽  
Maintenance Treatment ◽  
Fundic Gland

Fundic Gland Polyp With Parietal Cell Vacuolation Mimicking Signet Ring Cell Carcinoma

2021 ◽  
pp. 106689692199418
Author(s):  
John D. Coyne ◽  
S. Thampy
Keyword(s):  
Proton Pump Inhibitor ◽  
Cell Carcinoma ◽  
Parietal Cell ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Fundic Gland ◽  
Fundic Gland Polyp ◽  
Signet Ring ◽  
Ring Cell

Pseudo-signet ring parietal cell vacuolation has been described as a mimic of invasive signet ring cell carcinoma. Moreover, signet ring cell carcinoma has been described in a fundic gland polyp. This case demonstrates parietal cell vacuolation in a fundic gland polyp in a patient on a long-term proton pump inhibitor.

scholarly journals GASTRIC FUNDIC GLAND POLYPS: CAN HISTOLOGY BE USEFUL TO PREDICT PROTON PUMP INHIBITORS USE?

2018 ◽  
Vol 55 (4) ◽  
pp. 380-384
Author(s):  
Hugo Leite de Farias BRITO ◽  
Cynthia BARROS ◽  
Marcelle Vieira FREIRE ◽  
Miraldo Nascimento da SILVA FILHO ◽  
Tereza Virgínia NASCIMENTO
Keyword(s):  
Proton Pump Inhibitor ◽  
Proton Pump Inhibitors ◽  
Parietal Cell ◽  
Proton Pump ◽  
Proton Pump Inhibitor Therapy ◽  
Inhibitor Therapy ◽  
Fundic Gland ◽  
Acid Therapy ◽  
Fundic Gland Polyps ◽  
Two Samples

ABSTRACT BACKGROUND: Fundic gland polyps allegedly increased in frequency in recent decades, and had attracted great attention due to possible association with prolonged proton pump inhibitor therapy. Prolonged use of this drug could cause parietal cell hyperplasia, obstruction of glandular lumen and cystic dilation of the gland. OBJECTIVE: This study aims to analyze clinical and pathological features of fundic gland polyps in patients with and without proton pump inhibitor therapy in a selected population from Brazil. METHODS: It was selected a sample of 101 Brazilian patients (78 females and 23 males), from a five years retrospective search of the files from a private pathology laboratory. The patients had an average age of 57 years and we included patients with a histological diagnosis of fundic gland polyp. The clinical data were obtained from their files and all histological slides were reviewed and examined with hematoxylin and eosin (HE) and Giemsa. RESULTS: Information about the use or non-use of proton pump inhibitors (PPI) was obtained in 84 patient files. In 17 cases we could not determine if PPI were used or not. Among those in which the information was available, a positive history of anti-acid therapy was observed in 63 (75.0%) patients. Parietal cell hypertrophy/hyperplasia and parietal cell protrusions were detected in most slides. Histological findings were identical in PPI users and PPI negative patients. Helicobacter pylori infection was detected in just two samples. Epithelial dysplasia or adenocarcinoma were not observed in our cases. Histopathological analysis of fundic gland polyps could not distinguish between PPI and non-PPI related cases. Parietal cell cytoplasmic protrusions, an alleged marker of prolonged acid suppression therapy, was detected in both groups. CONCLUSION: Histological features could not discriminate anti-acid therapy related fundic glands polyps in our patients.

Parietal cell protrusions with fundic gland cysts and fundic gland polyps: Are they related or simply similar but distinguishable?

2000 ◽  
Vol 31 (12) ◽  
pp. 1536-1537 ◽  
Author(s):  
Paolo Declich ◽  
Stefano Bellone ◽  
Monica Porcellati ◽  
Aurora Bortoli ◽  
Claudio Gozzini ◽  
...  
Keyword(s):  
Parietal Cell ◽  
Fundic Gland ◽  
Fundic Gland Polyps

Letters to the Editor. Parietal cell hyperplasia with deep cystic dilations: a lesion closely mimicking fundic gland polyps

2000 ◽  
Vol 95 (2) ◽  
pp. 566-568 ◽  
Author(s):  
Paolo Declich ◽  
Luciana Ambrosiani ◽  
Stefano Bellone ◽  
Enrico Tavani ◽  
Roberta Grassini ◽  
...  
Keyword(s):  
Parietal Cell ◽  
Fundic Gland ◽  
Letters To The Editor ◽  
Cell Hyperplasia ◽  
Fundic Gland Polyps

scholarly journals Chance that matter or matter of chance: changing prevalence of fundic gland polyps and proton pump inhibitors

2021 ◽  
Vol 12 (5) ◽  
pp. 107-112
Author(s):  
Zeeshan Ahmad Wani ◽  
Muzzafer Mohamad Mir ◽  
Afaq Ahmad Khan ◽  
Iqbal Baba ◽  
Showket Mir ◽  
...  
Keyword(s):  
Proton Pump Inhibitors ◽  
Parietal Cell ◽  
Proton Pump ◽  
Western World ◽  
Fundic Gland ◽  
Cell Hyperplasia ◽  
Northern India ◽  
Cell Protrusion ◽  
Fundic Gland Polyps ◽  
One Year

Background: Proton pump inhibitors (PPI) are considered one of reasons for changing prevalence of gastric fundic gland polyps (FGP), not only in western world but trend is being seen in Asian countries as well. Aims and Objective: This study was designed to evaluate prevalence of FGP and to look into endoscopic and histological profile of these polyps in PPI users and non-PPI users. We also assessed background gastric mucosal histology in FGP patients. Materials and Methods: This is a retrospective observational study of 1800 cases. Medical records of patients who underwent esophagogastroduodenoscopy (EGD) in three gastroenterology centres between 2011 and 2019 were analysed at Noora super speciality Hospital, Kashmir; Northern India. Biopsy specimens of patients with FGP were reviewed by expert pathologists. PPI use was quantified as significant when Pantoprazole 40 mg per day or equivalent doses of other PPI was used four times or more per week for more than one year. Statistical Analysis was conducted using SPSS version 22. Results: FGP were most common, observed in 900 (50%) of all gastric polyp cases. PPI use one year and more was noted only in 360 (40%). FGP were mostly located in fundus 630 (70%), multiple in 840 (93.33%), with average size between 6 to 10 mm. On histology parietal cell hyperplasia, parietal cell protrusion and foveolar hyperplasia were seen in 666 (74%), 716(79.55%) and 254 (28.22%) cases respectively. Background gastric histology was normal in 543 (60.33%). Conclusions: FGP were most common gastric polyps in Northern India. We observed similar endoscopic and histological characters in FGP irrespective of whether cases were using PPI or not. Majority of cases had normal background gastric mucosal histology.

Sign in / Sign up

Export Citation Format

Share Document