Effect of ligands of opioid receptors on DNA synthesis and histamine concentration in the gastric mucosa and blood of albino rats

1989 ◽  
Vol 108 (2) ◽  
pp. 1152-1154
Author(s):  
A. G. Aleksandrovich ◽  
T. F. Zhdanova ◽  
S. S. Timoshin ◽  
R. V. Uchakina
Keyword(s):  
Gastric Mucosa ◽  
Dna Synthesis ◽  
Opioid Receptors ◽  
Albino Rats ◽  
Histamine Concentration

Effect of dalargin on DNA synthesis in the gastric mucosa of albino rats

2007 ◽  
Vol 144 (3) ◽  
pp. 314-316 ◽  
Author(s):  
E. U. Zivotova ◽  
M. U. Fleishman ◽  
O. A. Lebedko ◽  
E. N. Sazonova ◽  
S. S. Timoshin
Keyword(s):  
Gastric Mucosa ◽  
Dna Synthesis ◽  
Albino Rats

Mechanisms for the effect of arginine-containing dermorphin analogue on proliferative processes in the gastric mucosa of albino rats

2007 ◽  
Vol 144 (3) ◽  
pp. 309-311 ◽  
Author(s):  
M. U. Fleishman ◽  
E. U. Zhivotova ◽  
O. A. Lebedko ◽  
V. I. Deigin ◽  
S. S. Timoshin
Keyword(s):  
Gastric Mucosa ◽  
Albino Rats

Aging: altered responsiveness of gastric mucosa to epidermal growth factor

1989 ◽  
Vol 257 (4) ◽  
pp. G554-G560 ◽  
Author(s):  
A. P. Majumdar ◽  
F. L. Arlow
Keyword(s):  
Growth Factor ◽  
Gastric Mucosa ◽  
Epidermal Growth Factor ◽  
Dna Synthesis ◽  
Thymidine Kinase ◽  
Membrane Fraction ◽  
Kinase Activity ◽  
Thymidine Kinase Activity ◽  
Epidermal Growth ◽  
K Activity

The present investigation examines the responsiveness of the gastric mucosa to the growth-promoting action of epidermal growth factor (EGF) during advancing age. Two sets of experiments were performed. In the first set of experiments, groups of 4-, 8-, 16-, and 24-mo-old Fischer 344 rats were injected subcutaneously at 12-h intervals for 2 days with either EGF (10 micrograms/kg) in gelatin or the vehicle only (controls). The animals were killed 16-18 h after the last injection. The oxyntic gland mucosa was assayed for thymidine kinase and the rate of DNA synthesis in vitro (indicators of proliferative activity) as well as for tyrosine kinase (Tyr-k) activity. In control rats, the rate of DNA synthesis and thymidine kinase activity rose steadily between 4 and 24 mo of age. However, whereas Tyr-k activity in the gastric mucosal cytosol changed only marginally with age, activity of the enzyme in the membrane fraction rose steadily between 4 and 16 mo and then increased abruptly. EGF stimulated gastric mucosal DNA synthesis and thymidine kinase activity in 4- to 16-mo-old rats compared with the corresponding controls, but in the 24-mo-old animals, it caused a significant 40-50% inhibition. EGF had no demonstrable effect on Tyr-k activity in either cytosolic or membrane fraction. We postulated that Tyr-k activity might have returned to basal level 16-18 h after the last EGF injection.(ABSTRACT TRUNCATED AT 250 WORDS)

scholarly journals Anti-inflammatory activity of acacia catechu-bark aqueous solution in aspirin induced gastric ulcer in rodents

2021 ◽  
Vol 8 (12) ◽  
pp. 5649
Author(s):  
Uzma Waseem ◽  
Syeda Rizwana Jafri ◽  
Sarah Khalid ◽  
Fauzia Qureshi ◽  
Nadia Majeed ◽  
...  
Keyword(s):  
Gastric Mucosa ◽  
Inflammatory Cells ◽  
Protective Role ◽  
Gastric Injury ◽  
Medical Institute ◽  
Control Group ◽  
Albino Rats ◽  
Anti Inflammatory ◽  
Group B ◽  
Acacia Catechu

Background: Aspirin is amongst the most widely used drugs and has many adverse effects on gastric mucosa. Anti-inflammatory properties of Acacia catechu have been established already. Objective was to evaluate the histopathological changes induced by aspirin in the stomach of albino rats and to assess the protective effect of different doses of Acacia catechu.Methods: Experimental study Postgraduate Medical Institute, Lahore for 21 days. Forty-eight adult albino rats, both males and female, were divided into four groups A, B, C and D randomly; each comprising of 12 rats. Group A was control, group B was given aspirin 100 mg/kg and group C and D were given aspirin 100 mg/kg along with Acacia catechu 250 mg/kg and 500 mg/kg respectively by oral route. The rats from individual group were sacrificed on 3rd day, 7th day and 14th day and stomachs were examined under light microscope to observe the inflammatory cells infiltration.Results: Gross and microscopic findings on days 3, 7 and 14 were similar. Control groups A1, A2 and A3 showed normal healthy gastric mucosa and the least number of inflammatory cells. In group B, aspirin produced ulcerations and linear breaks; with highest inflammatory infiltrates. On microscopic examination, numerous inflammatory cells were noted. Group C and D rats had minimum ulcer index and fewer inflammatory cells.Conclusions: Acacia catechu has protective role against gastric injury by inhibiting inflammation. 

The Effect of Cold Stress on the Gastric Mucosa of Adult Male Albino Rats: A Light Microscope Study

2012 ◽  
Vol 19 (1) ◽  
Author(s):  
Ghada Abdel-Hamid ◽  
Rana El-Beshbishy ◽  
Afrah Al-Awa
Keyword(s):  
Gastric Mucosa ◽  
Cold Stress ◽  
Adult Male ◽  
Microscope Study ◽  
Light Microscope ◽  
Albino Rats

Effect of semax on homeostasis of gastric mucosa in albino rats

2000 ◽  
Vol 130 (3) ◽  
pp. 871-873 ◽  
Author(s):  
S. E. Zhuikova ◽  
E. A. Smirnova ◽  
Z. V. Bakaeva ◽  
G. E. Samonina ◽  
I. P. Ashmarin
Keyword(s):  
Gastric Mucosa ◽  
Albino Rats
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