Action of ethanol and limontar during antenatal development on lipid peroxidation and on the antioxidant protection system in the brain and liver tissue of fetal and neonatal rats

1991 ◽  
Vol 112 (6) ◽  
pp. 1711-1713 ◽  
Author(s):  
L. P. Bykova ◽  
T. P. Zhukova
Keyword(s):  
Lipid Peroxidation ◽  
Liver Tissue ◽  
Protection System ◽  
Antioxidant Protection ◽  
Neonatal Rats ◽  
Antenatal Development ◽  
Antioxidant Protection System ◽  
The Brain

scholarly journals Functional State of the Thyroid Gland and Lipid Peroxidation and Antioxidant Protection System in Women of Reproductive Age with Chronic Form of Parenteral Viral Hepatitis

2019 ◽  
Vol 4 (1) ◽  
pp. 31-35
Author(s):  
Maria A. Rashidova ◽  
Leonid F. Sholokhov ◽  
Marina A. Darenskaya ◽  
Lyubov I. Kolesnikova
Keyword(s):  
Lipid Peroxidation ◽  
Viral Hepatitis ◽  
Functional State ◽  
Chronic Viral Hepatitis ◽  
Protection System ◽  
Reproductive Age ◽  
Control Group ◽  
Antioxidant Protection ◽  
Chronic Form ◽  
Antioxidant Protection System

Background.Chronic viral hepatitis is a complex global problem and is still far from being solved. Many researchers point out influence of viral hepatitis on the reproductive system of women.Aim.To identify features of the functional state of pituitary-thyroid units of neuroendocrinal regulation, and to evaluate lipid peroxidation – antioxidant protection with determination of the oxidative stress coefficient in perimenopausal women with chronic form of hepatitis.Materials and methods. Study included 44 women with chronic viral hepatitis and 28 healthy women of the same age. Immunoabsorbent, spectrophotometric, fluorometric and statistical methods were used.Results.In patients with chronic viral hepatitis, we detected an increase in thyroxine levels – by 29.6% (р < 0.001) and free triiodothyronine values – by 65.7% (р = 0.008) in comparison with the control group. In the group with chronic viral hepatitis, the TBA-reactive products level increased by 1.9 times (р = 0.006), and superoxide dismutase activity decreased by 1.3 times (р < 0.001), total antioxidant activity – by 1.7 times (р < 0.001) and α-tocopherol level – by 1.3 times (р = 0.005) in comparison with the control group.Conclusions. The obtained data demonstrate the features of the pituitary-thyroid system functioning and the lipid peroxidation – antioxidant protection system in patients with chronic hepatitis. The chronic form of hepatitis is characterized by metabolic disorders that require a more careful approach in diagnosis and management.

scholarly journals Peculiarities and new prospects of management of patients with NSAID-gastropathy on the background of chronic pancreatitis in general-therapy practice

2020 ◽  
Vol 48 (3) ◽  
pp. 32-37
Author(s):  
L. S. Babinets ◽  
I. M. Halabitska
Keyword(s):  
Lipid Peroxidation ◽  
Chronic Pancreatitis ◽  
Treatment Regimen ◽  
Day Treatment ◽  
The State ◽  
Protection System ◽  
Antioxidant Protection ◽  
Nsaid Gastropathy ◽  
Antioxidant Protection System ◽  
Positive Effect

Introduction. The main pharmacological effects of NSAIDs are anti-inflammatory, the onset and conduction of a pain signal, the aggregation of blood elements, neoangiogenesis, cell apoptosis, etc. — make them indispensable in the treatment of inflammatory and degenerative diseases of the joints and spine, in particular osteoarthritis. NSAIDs account for 25% of all medical complications, including bleeding rates (25–40%), which is a serious medical and important socio-economic problem. The risk of developing NSAIDs-gastropathy is determined both by severity of COX-2 inhibitory effect and non-prostaglandin systemic and local effects. Use of proton pump inhibitors, histamine blockers (mainly children and adolescents), and synthetic analogues of prostaglandins, as well as drugs of cytoprotective action, is pathogenetically justified in the treatment of NSAIDs-gastropathy. One of the newest and most economically available, most metabolically high-technological is the vitamin drug Doctovit. Aim: to study the effectiveness of Doctovit in the complex therapy of patients with NSAIDs-gastropathy on the background of chronic pancreatitis by analyzing the morphological parameters, indices of antioxidant protection system and endotoxicosis system. Materials and methods. 42 patients with NSAID-gastropathy on the background of chronic pancreatitis were examined. Patients, comparable by clinical, gender criteria, severity of NSAID-gastropathy and treatment received — were divided into two groups: I control group (20 patients), 10-day treatment regimen: PPI pantoprazole (Controlok, Nolpase, Pantasan, etc.) 40 mg×2; cancellation of NSAIDs; II main group (22 patients), 10-day treatment regimen: PPI pantoprazole (Controlok, Nolpase, Pantasan, etc.) 40 mg×2; cancellation of NSAIDs; Doctovit 2 tablets per day after meals for 2 months. Compulsory components of medical complexes were outpatient regimen and normotrophic nutrition. All patients with NSAID-gastropathy underwent standardized clinical laboratory examination. At the beginning of the study and two months after the start of treatment EGDS + biopsy from 5 places with histological examination was performed. The level of endotoxicosis was defined by the level of sorption capacity of erythrocytes, which was determined according to A. A. Togaibayev technique. The state of lipid peroxidation was evaluated by the level of malonic aldehyde, the state of antioxidant protection system — by the levels of superoxide dismutase, catalase, SH-groups. Results and discussion. Morphological examination of gastric EGD biopsy specimens before and after treatment in the comparison groups showed statistically significant efficacy of the proposed treatment complex with the inclusion of Doctovit in influencing the established pathological features of NSAID-gastropathy. There was a statistically significant improvement in endotoxicosis in both study groups after treatment, but in the II group the positive effect was statistically more significant. The proposed correction programs had a positive effect on the lipid peroxidation, but the correction program used in II group had a statistically significantly better effect. Conclusion. In the complex treatment of NSAID-gastropathy on the background of chronic pancreatitis, it is advisable to use the vitamin complex Doctovit 2 tablets per day after meals for 2 months, which has a positive effect on the condition of the gastric mucosa, indices of lipid peroxidation and endotoxicosis.  

scholarly journals Periodontal tissue status and «lipid peroxidation - antioxidant protection» system in saliva and gingival fluid in petrochemical industry workers

2015 ◽  
Vol 96 (5) ◽  
pp. 759-763
Author(s):  
R I Sabitova ◽  
R T Bulyakov ◽  
D F Shakirov ◽  
F Kh Kamilov
Keyword(s):  
Lipid Peroxidation ◽  
Petrochemical Industry ◽  
Risk Groups ◽  
Protection System ◽  
Experimental Plant ◽  
Periodontal Tissue ◽  
Antioxidant Protection ◽  
Periodontal Tissues ◽  
Antioxidant Protection System ◽  
Gingival Fluid

Aim. To study periodontal tissue status and «lipid peroxidation - antioxidant protection» system in saliva and gingival fluid in petrochemical industry workers. Methods. 185 employees of JSC «Experimental Plant Neftechim» were included into the study. Besides the evaluation of dental status saliva and gingival fluid were analyzed for lipid peroxidation products - diene and triene conjugates, malondialdehyde, hydroperoxides and Schiff bases. Results. The rate of chronic generalized periodontitis in petrochemical industry workers was 100%, including moderate (47.03%), severe (35.13%) and mild (17.84%) degree. Enhancement of lipid peroxidation and antioxidant defense system activity were detected (in mild and moderate chronic generalized periodontitis) with increasing inflammatory and destructive processes in periodontal tissues. In severe chronic generalized periodontitis reduction in the antioxidant protection activity was observed along with the increasing of lipid peroxidation. Correlation analysis revealed a direct relationship between the periodontal tissue status and «lipid peroxidation - antioxidant protection» system. Conclusion. The prophylactic work should be organized among the petrochemical industry employees aiming to decrease risks of diseases; using the obtained data can be used in clinical practice to identify high-risk groups of patients with periodontal pathology.

scholarly journals Performance of Metabolic Parameters in Formation of Sleep Disorders in Menopausal Women

2019 ◽  
Vol 3 (6) ◽  
pp. 9-14
Author(s):  
N. V. Semenova ◽  
I. M. Madaeva ◽  
I. M. Mikhalevich ◽  
L. I. Kolesnikova
Keyword(s):  
Lipid Peroxidation ◽  
Sleep Disorders ◽  
Protection System ◽  
Antioxidant Protection ◽  
System Parameters ◽  
Informative Parameters ◽  
Menopausal Women ◽  
Perimenopausal Women ◽  
Total Antioxidant ◽  
Antioxidant Protection System

Background. It is known that menopausal women suffer from sleep disorders. As additional diagnostic methods, it is possible to use the equations of linear classification functions.Aim: to determine the most informative parameters among the lipid profile, the “lipid peroxidation – antioxidant protection” system parameters and the melatonin secretion chronobiological rhythms in menopausal women with sleep disorders.Materials and methods. 56 perimenopausal women and 70 postmenopausal ones in accordance with the inclusion criteria participated in this study. Diagnoses of insomnia and obstructive sleep apnea syndrome were made according to the results of specialized somnological questionnaires and polysomnographic monitoring. Spectrophotometric methods for studying of lipid metabolism and the “lipid peroxidation – antioxidant protection” system parameters, an enzyme immunoassay method for determining melatonin were also used. A multidimensional discriminant analysis to reveal the most informative parameters among the parameters studied was used.Results. The most informative indicators of the metabolic system for sleep disorders in perimenopausal women with insomnia are melatonin 06.00–07.00 h, melatonin 18.00–19.00 h, melatonin 23.00–00.00 h, ketodienes and conjugated trienes, oxidized glutathione; with insomnia and OSAS – melatonin 06.00–07.00 h, melatonin 12.00–13.00 h, melatonin 23.00–00.00 h, substrates with conjugated double bonds, total cholesterol; in postmenopausal women with insomnia – diene conjugates, α-tocopherol, total antioxidant capacity, active products of thiobarbituric acid, reduced glutathione; with insomnia and OSAS – total antioxidant capacity, α-tocopherol, substrates with conjugated double bonds.Conclusions. The results obtained indicate a great strain in the antioxidant protection system in menopausal women with sleep disorders in response to changes in free radical homeostasis.

scholarly journals Indices of free-radical oxidation and antioxidant system of rats with acute hepatitis combined with merkazolil-induced hypothyroidism

2015 ◽  
Vol 17 (3) ◽  
Author(s):  
O. Y. Zarichna
Keyword(s):  
Lipid Peroxidation ◽  
Free Radical ◽  
Acute Hepatitis ◽  
Liver Homogenate ◽  
Free Radical Oxidation ◽  
Protection System ◽  
Antioxidant Protection ◽  
Radical Oxidation ◽  
Galactosamine Hepatitis ◽  
Antioxidant Protection System

<p>In experiments on rats with modulated hypothyroidism, acute galactosamine hepatitis, acute hepatitis combined<br />with merkazolil-induced hypothyroidism the changes in the indices of free-radical oxidation in blood and liver<br />homogenate were studied. Results of the investigation indicate a pronounced increase of lipid peroxidation products,<br />both in blood and in liver homogenate against the backdrop of exhaustion of the enzymatic and non-enzymatic links<br />antioxidant protection system in animals with hypothyroidism. In case of acute galactosamine hepatitis increase of<br />lipid peroxidation products, both in blood and in liver homogenate against the background of activation units both<br />components of the antioxidant protection system was established. The most significant inhibition of the enzymatic<br />and non-enzymatic links antioxidant protection system suffered rats with acute hepatitis on the background of<br />hypothyroidism. It is concluded that failure revealed a mutual gain reflects the negative impact of acute toxic liver<br />injury and thyroid hormone deficiency.</p>

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