Indices of free-radical oxidation and antioxidant system of rats with acute hepatitis combined with merkazolil-induced hypothyroidism

<p>In experiments on rats with modulated hypothyroidism, acute galactosamine hepatitis, acute hepatitis combined<br />with merkazolil-induced hypothyroidism the changes in the indices of free-radical oxidation in blood and liver<br />homogenate were studied. Results of the investigation indicate a pronounced increase of lipid peroxidation products,<br />both in blood and in liver homogenate against the backdrop of exhaustion of the enzymatic and non-enzymatic links<br />antioxidant protection system in animals with hypothyroidism. In case of acute galactosamine hepatitis increase of<br />lipid peroxidation products, both in blood and in liver homogenate against the background of activation units both<br />components of the antioxidant protection system was established. The most significant inhibition of the enzymatic<br />and non-enzymatic links antioxidant protection system suffered rats with acute hepatitis on the background of<br />hypothyroidism. It is concluded that failure revealed a mutual gain reflects the negative impact of acute toxic liver<br />injury and thyroid hormone deficiency.</p>