Mechanism of action of ethanol on rat brain enkephalinase a activity

1984 ◽  
Vol 97 (6) ◽  
pp. 760-762
Author(s):  
L. F. Panchenko ◽  
O. S. Brusov ◽  
N. A. Belyaev
Keyword(s):  
Rat Brain ◽  
Mechanism Of Action ◽  
Enkephalinase A

Central vasopressin V1-blockade prevents salicylate but not acetaminophen antipyresis

1990 ◽  
Vol 68 (5) ◽  
pp. 1793-1798 ◽  
Author(s):  
M. F. Wilkinson ◽  
N. W. Kasting
Keyword(s):  
Rat Brain ◽  
Core Temperature ◽  
Mechanism Of Action ◽  
Arginine Vasopressin ◽  
Sodium Salicylate ◽  
Septal Area ◽  
Receptor Blockade ◽  
Drug Induced ◽  
Normal Core ◽  
The Brain

Recent evidence has suggested that the endogenous antipyretic arginine vasopressin (AVP) may participate in drug-induced antipyresis. This study sought to further those investigations by comparing the effects of two other antipyretic drugs, sodium salicylate and acetaminophen, administered intraperitoneally, during AVP V1-receptor blockade within the ventral septal area (VSA) of the rat brain. During endotoxin-evoked fever, V1-receptor blockade within the VSA of the conscious unrestrained rat significantly antagonized the antipyretic effects of salicylate. The effects of the V1-antagonist on salicylate-induced antipyresis were dose related. In contrast, the antipyresis elicited by acetaminophen was unaffected by VSA V1-antagonist pretreatment. Neither saline nor the V1-antagonist microinjected into the VSA of febrile or nonfebrile rats had any significant effects on the normal progression of endotoxin fever or normal core temperature, respectively. These data suggest that the mechanism of action of salicylate-induced antipyresis includes activation of AVP V1-type receptors within the VSA, as has been shown for indomethacin. However, the lack of effect of the V1-antagonist on antipyresis induced by acetaminophen indicates that not all antipyretic drugs act through the same mechanism in the brain.

Cardiolipins are ‘in vitro’ inhibitors of rat brain A probable mechanism of action (Na+ + K+)-dependent ATPase

1981 ◽  
Vol 642 (1) ◽  
pp. 96-105 ◽  
Author(s):  
Efrain Toro-Goyco ◽  
Matilde B. Rodriguez ◽  
Alan M. Preston ◽  
Arthur F. Rosenthal
Keyword(s):  
Rat Brain ◽  
Mechanism Of Action ◽  
Probable Mechanism ◽  
Dependent Atpase

scholarly journals The Mechanism Of Action Of Polyphenol On Changes In The Dynamics Of Calcium In The Synaptosomes Of The Rat Brain Against The Background Of Glutamate

2021 ◽  
Vol 03 (03) ◽  
pp. 48-55
Author(s):  
Khoshimov N.N. ◽  
Keyword(s):  
Calcium Channels ◽  
Calcium Channel ◽  
Rat Brain ◽  
Mechanism Of Action ◽  
Fluorescent Probes ◽  
Blocking Effect ◽  
Voltage Gated ◽  
Glutamate Binding ◽  
Voltage Gated Calcium Channels ◽  
Brain Synaptosomes

The manuscript shows a short data used using fluorescent probes to study the effect of polyphenol PС-7 on changes in the dynamics of intracellular Ca2+ content in rat brain synaptosomes, depending on the site of glutamate binding on calcium channels by a specific mediator with glutamate. To measure the amount of cytosolic Ca2+ synaptosomes, we calculated using the Grinkevich equation. It has been shown that polyphenol PС-7 binds to the β1-subunit of the voltage-gated calcium channel and allosterically changes its conformation so that the conductivity for Ca2+ ions increases through the channel, the blocking effect of polyphenol PС-7 can be explained by its binding to voltage-gated calcium channels and activating them.

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