Differential Pattern of c-fos mRNA in Rat Brain following Central and Systemic Administration of lnterleukin-1-Beta: Implications for Mechanism of Action

1996 ◽  
Vol 63 (3) ◽  
pp. 207-218 ◽  
Author(s):  
Heidi E.W. Day ◽  
Huda Akil
Keyword(s):  
Rat Brain ◽  
Mechanism Of Action ◽  
Systemic Administration ◽  
Differential Pattern

Central vasopressin V1-blockade prevents salicylate but not acetaminophen antipyresis

1990 ◽  
Vol 68 (5) ◽  
pp. 1793-1798 ◽  
Author(s):  
M. F. Wilkinson ◽  
N. W. Kasting
Keyword(s):  
Rat Brain ◽  
Core Temperature ◽  
Mechanism Of Action ◽  
Arginine Vasopressin ◽  
Sodium Salicylate ◽  
Septal Area ◽  
Receptor Blockade ◽  
Drug Induced ◽  
Normal Core ◽  
The Brain

Recent evidence has suggested that the endogenous antipyretic arginine vasopressin (AVP) may participate in drug-induced antipyresis. This study sought to further those investigations by comparing the effects of two other antipyretic drugs, sodium salicylate and acetaminophen, administered intraperitoneally, during AVP V1-receptor blockade within the ventral septal area (VSA) of the rat brain. During endotoxin-evoked fever, V1-receptor blockade within the VSA of the conscious unrestrained rat significantly antagonized the antipyretic effects of salicylate. The effects of the V1-antagonist on salicylate-induced antipyresis were dose related. In contrast, the antipyresis elicited by acetaminophen was unaffected by VSA V1-antagonist pretreatment. Neither saline nor the V1-antagonist microinjected into the VSA of febrile or nonfebrile rats had any significant effects on the normal progression of endotoxin fever or normal core temperature, respectively. These data suggest that the mechanism of action of salicylate-induced antipyresis includes activation of AVP V1-type receptors within the VSA, as has been shown for indomethacin. However, the lack of effect of the V1-antagonist on antipyresis induced by acetaminophen indicates that not all antipyretic drugs act through the same mechanism in the brain.

Cardiolipins are ‘in vitro’ inhibitors of rat brain A probable mechanism of action (Na+ + K+)-dependent ATPase

1981 ◽  
Vol 642 (1) ◽  
pp. 96-105 ◽  
Author(s):  
Efrain Toro-Goyco ◽  
Matilde B. Rodriguez ◽  
Alan M. Preston ◽  
Arthur F. Rosenthal
Keyword(s):  
Rat Brain ◽  
Mechanism Of Action ◽  
Probable Mechanism ◽  
Dependent Atpase

Effects of Systemic Administration of Saxitoxin on Serotonin Levels in Some Discrete Rat Brain Regions

2009 ◽  
Vol 5 (4) ◽  
pp. 336-342 ◽  
Author(s):  
C. Cervantes ◽  
R. Duran ◽  
L. Faro ◽  
P. Alfonso
Keyword(s):  
Rat Brain ◽  
Brain Regions ◽  
Systemic Administration ◽  
Rat Brain Regions

scholarly journals Acute systemic administration of morphine selectively increases mu opioid receptor binding in the rat brain

Neuropeptides ◽  
1984 ◽  
Vol 5 (1-3) ◽  
pp. 117-120 ◽  
Author(s):  
James W. Lewis ◽  
Michael E. Lewis ◽  
Deborah J. Loomus ◽  
Huda Akil
Keyword(s):  
Rat Brain ◽  
Opioid Receptor ◽  
Receptor Binding ◽  
Mu Opioid Receptor ◽  
Systemic Administration ◽  
Mu Opioid ◽  
Opioid Receptor Binding

Regional changes of tissue pH and ATP content in rat brain following systemic administration of kainic acid

1990 ◽  
Vol 514 (2) ◽  
pp. 352-354 ◽  
Author(s):  
Shuichi Kobayashi ◽  
Haruhiko Kikuchi ◽  
Masatsune Ishikawa ◽  
Kenji Hashimoto
Keyword(s):  
Rat Brain ◽  
Kainic Acid ◽  
Systemic Administration ◽  
Atp Content ◽  
Tissue Ph
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