Detection of elements of structural commonality of substances with similar effects on the cell signal systems

1992 ◽  
Vol 26 (2) ◽  
pp. 116-120
Author(s):  
G. I. Poda ◽  
I. V. Tetko ◽  
S. E. Mogilevich ◽  
A. I. Luik
Keyword(s):  
Cell Signal ◽  
Signal Systems ◽  
Structural Commonality

Soviet Signal Systems

1966 ◽  
Vol 11 (8) ◽  
pp. 374-375
Author(s):  
L. Zusne
Keyword(s):  
Signal Systems

Rapid prototyping of algorithmic A/D converters based on FPAA devices

2013 ◽  
Vol 61 (3) ◽  
pp. 691-696 ◽  
Author(s):  
R. Suszynski ◽  
K. Wawryn
Keyword(s):  
Rapid Prototyping ◽  
Sinusoidal Signal ◽  
Digital Converter ◽  
Mixed Signal ◽  
Analog Digital Converter ◽  
Signal Systems ◽  
Programmable Analog ◽  
Field Programmable ◽  
Field Programmable Analog Array

Abstract A rapid prototyping method for designing mixed signal systems has been presented in the paper. The method is based on implementation of the field programmable analog array (FPAA) to configure and reconfigure mixed signal systems. A serial algorithmic analog digital converter has been used as an example. Three converter architectures have been selected and implemented FPAA device. To verify and illustrate converters operation and prototyping capabilities, implemented converters have been excited by a sinusoidal signal. Analog sinusoidal excitations, digital responses and sinusoidal waveforms after reconstruction are presented.

Arithmetic Compactors Design: Application to Mixed Signal Systems

2012 ◽  
Vol 1 (1) ◽  
pp. 1-7
Author(s):  
Vadim Geurkov ◽  
◽  
Lev Kirischian ◽  
Keyword(s):  
Mixed Signal ◽  
Signal Systems

scholarly journals The Role of ArlRS and VraSR in Regulating Ceftaroline Hypersusceptibility in Methicillin-Resistant Staphylococcus aureus

Antibiotics ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 821
Author(s):  
Maite Villanueva ◽  
Melanie Roch ◽  
Iñigo Lasa ◽  
Adriana Renzoni ◽  
William L. Kelley
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Control Strategies ◽  
Population Analysis ◽  
Methicillin Resistant ◽  
Signal Systems ◽  
Fifth Generation ◽  
Sensing Systems ◽  
Two Component ◽  
Two Component Systems

Methicillin-resistant Staphylococcus aureus infections are a global health problem. New control strategies, including fifth-generation cephalosporins such as ceftaroline, have been developed, however rare sporadic resistance has been reported. Our study aimed to determine whether disruption of two-component environmental signal systems detectably led to enhanced susceptibility to ceftaroline in S. aureus CA-MRSA strain MW2 at sub-MIC concentrations where cells normally continue to grow. A collection of sequential mutants in all fifteen S. aureus non-essential two-component systems (TCS) was first screened for ceftaroline sub-MIC susceptibility, using the spot population analysis profile method. We discovered a role for both ArlRS and VraSR TCS as determinants responsible for MW2 survival in the presence of sub-MIC ceftaroline. Subsequent analysis showed that dual disruption of both arlRS and vraSR resulted in a very strong ceftaroline hypersensitivity phenotype. Genetic complementation analysis confirmed these results and further revealed that arlRS and vraSR likely regulate some common pathway(s) yet to be determined. Our study shows that S. aureus uses particular TCS environmental sensing systems for this type of defense and illustrates the proof of principle that if these TCS were inhibited, the efficacy of certain antibiotics might be considerably enhanced.

Sign in / Sign up

Export Citation Format

Share Document