Effects of Jianpi Huoxue Decoction on Kupffer cell signal pathway activation in rats with liver injury induced by Lieber-Decarli liquid diet and lipopolysaccharide

2007 ◽  
pp. 302-306 ◽  
Author(s):  
Jinghua Peng
Keyword(s):  
Liver Injury ◽  
Kupffer Cell ◽  
Signal Pathway ◽  
Liquid Diet ◽  
Cell Signal ◽  
Pathway Activation

Kupffer cell inactivation ameliorates immune liver injury via TNF-α/TNFR1 signal pathway in trichloroethylene sensitized mice

2020 ◽  
Vol 42 (6) ◽  
pp. 545-555
Author(s):  
Jia-Xiang Zhang ◽  
Qiong-Ying Xu ◽  
Yi Yang ◽  
Na Li ◽  
Yan Zhang ◽  
...  
Keyword(s):  
Liver Injury ◽  
Kupffer Cell ◽  
Signal Pathway ◽  
Cell Inactivation ◽  
Tnf Α

Profiling Signal Pathway Activation during Lymphangiogenesis

2007 ◽  
Vol 21 (6) ◽  
Author(s):  
Lee Virn Leak ◽  
Emanuel F. Petrocion ◽  
Lance A. Liotta
Keyword(s):  
Signal Pathway ◽  
Pathway Activation

scholarly journals Bradykinin contributes to immune liver injury via B2R receptor-mediated pathways in trichloroethylene sensitized mice: A role in Kupffer cell activation

Toxicology ◽  
2019 ◽  
Vol 415 ◽  
pp. 37-48 ◽  
Author(s):  
Jiaxiang Zhang ◽  
Na Li ◽  
Ling Yang ◽  
Haibo Xie ◽  
Yi Yang ◽  
...  
Keyword(s):  
Liver Injury ◽  
Kupffer Cell ◽  
Cell Activation

scholarly journals Antiapoptotic activity of Chlamydia trachomatis Pgp3 protein involves activation of the ERK1/2 pathway mediated by upregulation of DJ-1 protein

2019 ◽  
Vol 77 (9) ◽  
Author(s):  
Fangzhen Luo ◽  
Mingyi Shu ◽  
Silu Gong ◽  
Yating Wen ◽  
Bei He ◽  
...  
Keyword(s):  
Chlamydia Trachomatis ◽  
Hela Cells ◽  
Signal Pathway ◽  
Immune Defense ◽  
Apoptosis Resistance ◽  
Host Cell Apoptosis ◽  
Pathway Activation ◽  
Tnf Α ◽  
Antiapoptotic Activity

ABSTRACT Chlamydia trachomatis has evolved strategies to prevent host cell apoptosis to evade the host immune defense. However, the precise mechanisms of antiapoptotic activity of C. trachomatis still need to be clarified. Pgp3, one of eight plasmid proteins of C. trachomatis, has been identified to be closely associated with chlamydial virulence. In this study, we attempted to explore the effects and the mechanisms of Pgp3 protein on apoptosis in HeLa cells; the results showed that Pgp3 increased Bcl-2/Bax ratio and prevented caspase-3 activation to suppress apoptosis induced by TNF-α and cycloheximide (CHX) through ERK1/2 pathway activation. Downregulation of DJ-1 with siRNA-DJ-1(si-DJ-1) reduced ERK1/2 phosphorylation and elevated apoptotic rate significantly in Pgp3-HeLa cells. However, inhibition of ERK1/2 signal pathway with ERK inhibitor PD98059 had little effect on DJ-1 expression. These findings confirm that plasmid protein Pgp3 contributes to apoptosis resistance through ERK1/2 signal pathway mediated by upregulation of DJ-1 expression. Therefore, the present study provided novel insights into the role of Pgp3 in apoptosis and suggested that manipulation of the host apoptosis response could be a new approach for the prevention and treatment of C. trachomatis infection.

29 Kupffer cell generated death ligands potentiate cholestatic liver injury

Hepatology ◽  
2003 ◽  
Vol 38 ◽  
pp. 169-169
Author(s):  
A CANBAY ◽  
A FELDSTEIN ◽  
H HIGUCHI ◽  
N WERNEBURG ◽  
A GRAMBIHLER ◽  
...  
Keyword(s):  
Liver Injury ◽  
Kupffer Cell ◽  
Cholestatic Liver Injury

Effects of Iron Overload and Lindane Intoxication in Relation to Oxidative Stress, Kupffer Cell Function, and Liver Injury in the Rat

2001 ◽  
Vol 170 (1) ◽  
pp. 23-28 ◽  
Author(s):  
Barbara Junge ◽  
Yasna Carrion ◽  
Cleofina Bosco ◽  
Monica Galleano ◽  
Susana Puntarulo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Injury ◽  
Iron Overload ◽  
Kupffer Cell ◽  
Cell Function
Sign in / Sign up

Export Citation Format

Share Document