Effect of pharmacological preparations on the alcohol consumption of animals under conditions of free choice

1981 ◽  
Vol 15 (7) ◽  
pp. 500-503
Author(s):  
M. M. Borisov ◽  
T. P. Mufazalova
Keyword(s):  
Alcohol Consumption ◽  
Free Choice

Effect of caffeine on alcohol consumption and alcohol-induced conditioned place preference in rodents

2018 ◽  
Vol 30 (1) ◽  
pp. 19-28 ◽  
Author(s):  
Agbonlahor Okhuarobo ◽  
Ighodaro Igbe ◽  
Abdulmajid Yahaya ◽  
Zakariya Sule
Keyword(s):  
Alcohol Consumption ◽  
Conditioned Place Preference ◽  
Adenosine Receptors ◽  
Free Choice ◽  
Place Preference ◽  
Priming Dose ◽  
Alcohol Deprivation Effect ◽  
Adenosine Receptor Antagonist ◽  
Deprivation Effect ◽  
Unlimited Access

Abstract Background The aim of the study was to determine the effect of caffeine on alcohol consumption with or without deprivation and alcohol-induced conditioned place preference. Methods In the present study, we examined the effects of caffeine (2.5, 5 and 10 mg/kg) on alcohol consumption in Wistar rats with or without periods of deprivation in an unlimited-access, two-bottle, free choice drinking procedure after a stable baseline alcohol consumption was established. Conditioned place preference (CPP) was established by intraperitoneal injections of alcohol (2 g/kg) in a 12-day conditioning schedule in mice. The effect of caffeine (3 mg/kg) on CPP expression was determined by a final post-conditioning test following 12 conditioning sessions with alcohol. The effect of caffeine (3 mg/kg) on the reinstatement of alcohol-induced CPP was determined in a final post-conditioning test following 12 conditioning sessions with alcohol and the extinction of alcohol-induced CPP. Results Alcohol deprivation for 3 days did not result in alcohol deprivation effect (ADE). While caffeine (10 mg/kg) caused a significant (p<0.05) reduction in alcohol consumption compared with the baseline following a period of alcohol deprivation, it did not cause a change in alcohol consumption compared with the baseline in the study without alcohol deprivation phase. Caffeine significantly (p<0.05) reduced the expression of alcohol-induced CPP compared to saline and blocked the reinstatement of alcohol-induced CPP following the injection of a priming dose (0.4 g/kg) of alcohol. Conclusions Given that caffeine is an adenosine receptor antagonist, our findings suggest a role for adenosine receptors in the alcohol reward and alcohol-seeking behaviour.

Free-Choice Alcohol Consumption in Mice After Application of the Appetite Regulating Peptide Leptin

2001 ◽  
Vol 25 (5) ◽  
pp. 787-789 ◽  
Author(s):  
F. Kiefer ◽  
H. Jahn ◽  
K. Wolf ◽  
P. Kampf ◽  
K. Knaudt ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Free Choice

Alcohol consumption patterns in heavy drinkers with and without alcoholic liver disease (ALD)

2001 ◽  
Vol 120 (5) ◽  
pp. A117-A117
Author(s):  
K DEAR ◽  
M BRADLEY ◽  
K MCCORMACK ◽  
R PECK ◽  
D GLEESON
Keyword(s):  
Liver Disease ◽  
Alcohol Consumption ◽  
Alcoholic Liver Disease ◽  
Consumption Patterns ◽  
Heavy Drinkers
Sign in / Sign up

Export Citation Format

Share Document