Effect of naltrexone on alcohol consumption during chronic alcohol drinking and after a period of imposed abstinence in free-choice drinking rhesus monkeys

1991 ◽  
Vol 104 (3) ◽  
pp. 367-376 ◽  
Author(s):  
M. Kornet ◽  
C. Goosen ◽  
J. M. Van Ree
Keyword(s):  
Alcohol Consumption ◽  
Alcohol Drinking ◽  
Rhesus Monkeys ◽  
Free Choice ◽  
Chronic Alcohol

scholarly journals Chronic alcohol consumption impairs visuo-spatial associative memory in periadolescent rhesus monkeys

2011 ◽  
Vol 114 (1) ◽  
pp. 31-40 ◽  
Author(s):  
Rebecca D. Crean ◽  
Sophia A. Vandewater ◽  
Simon N. Katner ◽  
Salvador Huitron-Resendiz ◽  
Michael A. Taffe
Keyword(s):  
Alcohol Consumption ◽  
Associative Memory ◽  
Rhesus Monkeys ◽  
Chronic Alcohol ◽  
Chronic Alcohol Consumption

scholarly journals Chronic alcohol drinking persistently suppresses thalamostriatal excitation of cholinergic neurons to impair cognitive flexibility

2021 ◽  
Author(s):  
Tengfei Ma ◽  
Zhenbo Huang ◽  
Xueyi Xie ◽  
Xiaowen Zhuang ◽  
Matthew Childs ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Cognitive Flexibility ◽  
Alcohol Drinking ◽  
Long Term Potentiation ◽  
D1 Receptor ◽  
Chronic Alcohol ◽  
Glutamatergic Transmission ◽  
Chronic Alcohol Consumption ◽  
Cholinergic Interneurons

Exposure to addictive substances impairs flexible decision-making. Cognitive flexibility is mediated by striatal cholinergic interneurons (CINs). However, how chronic alcohol drinking alters cognitive flexibility through CINs remains unclear. Here, we report that chronic alcohol consumption and withdrawal impaired reversal of instrumental learning. Chronic alcohol consumption and withdrawal also caused a long-lasting (21 d) reduction of excitatory thalamic inputs onto CINs and reduced pause response of CINs in the dorsomedial striatum (DMS). CINs are known to inhibit glutamatergic transmission in dopamine D1 receptor-expressing medium spiny neurons (D1-MSNs) but facilitate this transmission in D2-MSNs, which may contribute to flexible behavior. We discovered that chronic alcohol drinking impaired CIN-mediated inhibition in D1-MSNs and facilitation in D2-MSNs. Importantly, in vivo optogenetic induction of long-term potentiation of thalamostriatal transmission in DMS CINs rescued alcohol-induced reversal learning deficits. These results demonstrate that chronic alcohol drinking reduces thalamic excitation of DMS CINs, compromising their regulation of glutamatergic transmission in MSNs, which may contribute to alcohol-induced impairment of cognitive flexibility. These findings provide a neural mechanism underlying inflexible drinking in alcohol use disorder.

Effect of the Covid-19 Italian lockdown on human health: the analysis of alcohol consumption for aware quarantine (Preprint)

2020 ◽  
Author(s):  
Chiara Mazzarella ◽  
Annamaria Spina ◽  
Marcello Dallio ◽  
Antonietta Gerarda Gravina ◽  
Mario Romeo ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Alcohol Abuse ◽  
Psychosocial Factors ◽  
Alcohol Drinking ◽  
Psychosocial Support ◽  
Human Life ◽  
Stressful Event ◽  
Drinking Behaviour ◽  
Drinking Habits ◽  
Specific Subset

BACKGROUND Italy has been one of the first western countries seriously involved in the COVID-19 pandemic in the first months of 2020 and so that the national government was forced to impose a long lockdown period, stopping all the people aggregation outdoor and indoor activities. From a social point of view this period of domestic confinement resulted in deep changes of behaviours and lifestyles, promoting in many people the onset of psychological symptoms and signs (including anxiety, depression, insomnia, and irritability among others) already known as associated with drug and alcohol abuse OBJECTIVE this study aims to assess the variation of alcohol drinking habits in a sample of Italian citizens during the COVID-19 lockdown and to identify the psychosocial factors surrounding it, in order to assess the specific subset of the population that could need psychosocial support during these events METHODS An online anonymous questionnaire was created and submitted from 9th April 2020 to 28th April 2020 using social medias and e-mails. Questions were related to personal details such as age, work, instruction, and, moreover, to alcohol drinking habits during the lockdown, including Alcohol Use Disorders Identification Test (AUDIT C) test questions RESULTS A total of 1234 surveys were filled out by subjects with an age range from 18 to 80 years old. An increase in both anxiety and fear has been detected in most of the participants (63% and 61% respectively) with a direct (r=0.652; p<0.001) relationship between them. Participants older than 50 years showed the strongest correlation between alcohol consumption, fear, and anxiety, (r=0.830, P <0.001 and r=0.741, P<0.001, respectively). Subjects living alone experienced a stronger association between anxiety, fear, and higher level of alcohol consumption (r: 0.529; P<0.001; r: 0.628, P<0.001 respectively). Moreover, 18% of participants increased alcohol consumption drinking during the lockdown. These subjects showed a lower frequency of alcohol consumption before the lockdown in comparison to the rest of the study population (2.5±0.96 vs 3±1.03, P<0.0001 respectively). Moreover, comparing the abovementioned groups, the percentage of subjects who experienced higher alcohol assumption before the 11th of March was higher in those that didn't change their drinking behaviour during the lockdown in comparison to that portion of them that experienced a worsening of alcohol abuse (r: 30.422, P<0.0001) CONCLUSIONS according to these data, during the Italian lockdown due to COVID 19 pandemic, different kind of people experienced an increase in alcohol drinking. Several psychosocial factors are involved in determining the increase in harmful alcohol consumption during this extraordinary stressful event and they must be addressed by the healthcare support in order to avoid awful lockdown impact on human life

Effects of Stress on Alcohol Consumption in Rats Selectively Bred for High or Low Alcohol Drinking

2004 ◽  
Vol 28 (3) ◽  
pp. 385-393 ◽  
Author(s):  
Julia A. Chester ◽  
Annette M. Blose ◽  
Mark Zweifel ◽  
Janice C. Froehlich
Keyword(s):  
Alcohol Consumption ◽  
Alcohol Drinking ◽  
Effects Of Stress ◽  
Low Alcohol

scholarly journals Chronic Alcohol Consumption Leads to a Tissue Specific Expression of Uncoupling Protein-2

2015 ◽  
Vol 12 (12) ◽  
pp. 995-999 ◽  
Author(s):  
Jan A. Graw ◽  
Clarissa von Haefen ◽  
Deniz Poyraz ◽  
Nadine Möbius ◽  
Marco Sifringer ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Uncoupling Protein ◽  
Uncoupling Protein 2 ◽  
Chronic Alcohol ◽  
Specific Expression ◽  
Chronic Alcohol Consumption ◽  
Tissue Specific ◽  
Tissue Specific Expression
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