Neuronal loss, neurofibrillary tangles and granulovacuolar degeneration in the hippocampus with ageing and dementia

1977 ◽  
Vol 37 (2) ◽  
pp. 111-118 ◽  
Author(s):  
M. J. Ball
Keyword(s):  
Neurofibrillary Tangles ◽  
Neuronal Loss ◽  
Granulovacuolar Degeneration

scholarly journals Tauopathies: A Distinct Class of Neurodegenerative Diseases

2007 ◽  
Vol 10 (2) ◽  
pp. 3-14 ◽  
Author(s):  
M Ozansoy ◽  
A Başak
Keyword(s):  
Neurodegenerative Diseases ◽  
Neurofibrillary Tangles ◽  
Neuronal Loss ◽  
Corticobasal Degeneration ◽  
Chromosome 17 ◽  
Cell Degeneration ◽  
Distinct Class ◽  
Postencephalitic Parkinsonism ◽  
Tau Isoforms ◽  
Niemann Pick

Tauopathies: A Distinct Class of Neurodegenerative DiseasesNeurodegenerative diseases are characterized by neuronal loss and intraneuronal accumulation of fibrillary materials, of which, neurofibrillary tangles (NFT) are the most common. Neurofibrillary tangles also occur in normal aging and contain the hyperphosphorylated microtubule-associated protein tau. A detailed presentation is made of the molecular bases of Alzheimer's disease (AD), postencephalitic parkinsonism, amyotrophic lateral sclerosis/parkinsonism-dementia complex (ALS/PDC) of Guam, progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), Pick's disease, frontotemporal dementia (FTD), Down's syndrome, myotonic dystrophy (DM) and Niemann-Pick Type C (NPC) disease, which are considered to be common tauopathies. The unique human tau gene extends over 100 kb of the long arm of chromosome 17 and contains 16 exons. The human brain contains six tau isoforms that contain from 352 to 441 amino acids. To date, 34 pathogenic tau mutations have been described among 101 families affected by FTD with parkinsonism linked to chromosome 17 (FTDP-17). These mutations may involve alternative splicing of exon 10 that lead to changes in the proportion of 4-repeat- and 3-repeat-tau isoforms, or may modify tau interactions with microtubules. Tau aggregates differ in degree of phosphorylation and in content of tau isoforms. Five classes of tauopathies have been defined depending on the type of tau aggregates. The key event in tauopathies is the disorganization of the cytoskeleton, which is based on mutations/polymorphisms in the tau gene and lead to nerve cell degeneration. In this review, tauopathies as a distinct class of neurodegenerative diseases are discussed with emphasis on their molecular pathology and genetics.

Extracellular neurofibrillary tangles reflect neuronal loss and provide further evidence of extensive protein cross-linking in Alzheimer disease

1995 ◽  
Vol 89 (4) ◽  
pp. 291-295 ◽  
Author(s):  
P. Cras ◽  
Mark A. Smith ◽  
Peggy L. Richey ◽  
Sandra L. Siedlak ◽  
Paul Mulvihill ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Neurofibrillary Tangles ◽  
Neuronal Loss ◽  
Cross Linking ◽  
Protein Cross Linking

scholarly journals Necrosome complex detected in granulovacuolar degeneration is associated with neuronal loss in Alzheimer’s disease

2019 ◽  
Vol 139 (3) ◽  
pp. 463-484 ◽  
Author(s):  
Marta J. Koper ◽  
Evelien Van Schoor ◽  
Simona Ospitalieri ◽  
Rik Vandenberghe ◽  
Mathieu Vandenbulcke ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neuronal Loss ◽  
Granulovacuolar Degeneration

scholarly journals Lysosomal Fusion Dysfunction as a Unifying Hypothesis for Alzheimer's Disease Pathology

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Kristen E. Funk ◽  
Jeff Kuret
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Progression ◽  
Neurofibrillary Tangles ◽  
Recent Literature ◽  
Senile Plaques ◽  
Disease Onset ◽  
Granulovacuolar Degeneration

Alzheimer's disease is characterized pathologically by extracellular senile plaques, intracellular neurofibrillary tangles, and granulovacuolar degeneration. It has been debated whether these hallmark lesions are markers or mediators of disease progression, and numerous paradigms have been proposed to explain the appearance of each lesion individually. However, the unfaltering predictability of these lesions suggests a single pathological nidus central to disease onset and progression. One of the earliest pathologies observed in Alzheimer's disease is endocytic dysfunction. Here we review the recent literature of endocytic dysfunction with particular focus on disrupted lysosomal fusion and propose it as a unifying hypothesis for the three most-studied lesions of Alzheimer's disease.

scholarly journals Re-examining tau-immunoreactive pathology in the population: granulovacuolar degeneration and neurofibrillary tangles

2015 ◽  
Vol 7 (1) ◽  
Author(s):  
Sally Hunter ◽  
◽  
Thais Minett ◽  
Tuomo Polvikoski ◽  
Elizabeta Mukaetova-Ladinska ◽  
...  
Keyword(s):  
Neurofibrillary Tangles ◽  
Granulovacuolar Degeneration

Extracellular neurofibrillary tangles reflect neuronal loss and provide further evidence of extensive protein cross-linking in Alzheimer disease

1995 ◽  
Vol 89 (4) ◽  
pp. 291-295 ◽  
Author(s):  
Patrick Cras ◽  
Mark A. Smith ◽  
Peggy L. Richey ◽  
Sandra L. Siedlak ◽  
Paul Mulvihill ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Neurofibrillary Tangles ◽  
Neuronal Loss ◽  
Cross Linking ◽  
Protein Cross Linking
Sign in / Sign up

Export Citation Format

Share Document