Topographic distribution of neurofibrillary tangles and granulovacuolar degeneration in hippocampal cortex of aging and demented patients. A quantitative study

1978 ◽  
Vol 42 (2) ◽  
pp. 73-80 ◽  
Author(s):  
M. J. Ball
Keyword(s):  
Quantitative Study ◽  
Neurofibrillary Tangles ◽  
Granulovacuolar Degeneration ◽  
Topographic Distribution

scholarly journals Lysosomal Fusion Dysfunction as a Unifying Hypothesis for Alzheimer's Disease Pathology

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Kristen E. Funk ◽  
Jeff Kuret
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Progression ◽  
Neurofibrillary Tangles ◽  
Recent Literature ◽  
Senile Plaques ◽  
Disease Onset ◽  
Granulovacuolar Degeneration

Alzheimer's disease is characterized pathologically by extracellular senile plaques, intracellular neurofibrillary tangles, and granulovacuolar degeneration. It has been debated whether these hallmark lesions are markers or mediators of disease progression, and numerous paradigms have been proposed to explain the appearance of each lesion individually. However, the unfaltering predictability of these lesions suggests a single pathological nidus central to disease onset and progression. One of the earliest pathologies observed in Alzheimer's disease is endocytic dysfunction. Here we review the recent literature of endocytic dysfunction with particular focus on disrupted lysosomal fusion and propose it as a unifying hypothesis for the three most-studied lesions of Alzheimer's disease.

scholarly journals Re-examining tau-immunoreactive pathology in the population: granulovacuolar degeneration and neurofibrillary tangles

2015 ◽  
Vol 7 (1) ◽  
Author(s):  
Sally Hunter ◽  
◽  
Thais Minett ◽  
Tuomo Polvikoski ◽  
Elizabeta Mukaetova-Ladinska ◽  
...  
Keyword(s):  
Neurofibrillary Tangles ◽  
Granulovacuolar Degeneration

Quantitative study of the topographic distribution of conjunctival lymphatic vessels in the monkey

2012 ◽  
Vol 94 (1) ◽  
pp. 90-97 ◽  
Author(s):  
Wenyi Guo ◽  
Yuanfang Zhu ◽  
Paula K. Yu ◽  
Xiaobo Yu ◽  
Xinghuai Sun ◽  
...  
Keyword(s):  
Quantitative Study ◽  
Lymphatic Vessels ◽  
Topographic Distribution

Two distinct subgroups of senile dementia of Alzheimer type: Quantitative study of neurofibrillary tangles

2003 ◽  
Vol 23 (4) ◽  
pp. 282-289 ◽  
Author(s):  
Yutaka Mizuno ◽  
Kenji Ikeda ◽  
Kuniaki Tsuchiya ◽  
Ryoko Ishihara ◽  
Hiroto Shibayama
Keyword(s):  
Quantitative Study ◽  
Neurofibrillary Tangles ◽  
Senile Dementia ◽  
Alzheimer Type ◽  
Dementia Of Alzheimer Type
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