Extracellular neurofibrillary tangles reflect neuronal loss and provide further evidence of extensive protein cross-linking in Alzheimer disease

1995 ◽  
Vol 89 (4) ◽  
pp. 291-295 ◽  
Author(s):  
P. Cras ◽  
Mark A. Smith ◽  
Peggy L. Richey ◽  
Sandra L. Siedlak ◽  
Paul Mulvihill ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Neurofibrillary Tangles ◽  
Neuronal Loss ◽  
Cross Linking ◽  
Protein Cross Linking

Extracellular neurofibrillary tangles reflect neuronal loss and provide further evidence of extensive protein cross-linking in Alzheimer disease

1995 ◽  
Vol 89 (4) ◽  
pp. 291-295 ◽  
Author(s):  
Patrick Cras ◽  
Mark A. Smith ◽  
Peggy L. Richey ◽  
Sandra L. Siedlak ◽  
Paul Mulvihill ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Neurofibrillary Tangles ◽  
Neuronal Loss ◽  
Cross Linking ◽  
Protein Cross Linking

scholarly journals Beta Amyloid Deposition and Neurofibrillary Tangles Spontaneously Occur in the Brains of Captive Cheetahs (Acinonyx jubatus)

2011 ◽  
Vol 49 (2) ◽  
pp. 304-312 ◽  
Author(s):  
S. Serizawa ◽  
J. K. Chambers ◽  
Y. Une
Keyword(s):  
Alzheimer Disease ◽  
Neurodegenerative Disease ◽  
Cognitive Dysfunction ◽  
Neurofibrillary Tangles ◽  
Neuronal Loss ◽  
Neuronal Somata ◽  
Acinonyx Jubatus ◽  
Parahippocampal Cortex ◽  
Age Related ◽  
Spontaneous Occurrence

Alzheimer disease is a dementing disorder characterized pathologically by Aβ deposition, neurofibrillary tangles, and neuronal loss. Although aged animals of many species spontaneously develop Aβ deposits, only 2 species (chimpanzee and wolverine) have been reported to develop Aβ deposits and neurofibrillary tangles in the same individual. Here, the authors demonstrate the spontaneous occurrence of Aβ deposits and neurofibrillary tangles in captive cheetahs ( Acinonyx jubatus). Among 22 cheetahs examined in this study, Aβ deposits were observed in 13. Immunostaining (AT8) revealed abnormal intracellular tau immunoreactivity in 10 of the cheetahs with Aβ deposits, and they were mainly distributed in the parahippocampal cortex and CA1 in a fashion similar to that in human patients with Alzheimer disease. Ultrastructurally, bundles of straight filaments filled the neuronal somata and axons, consistent with tangles. Interestingly, 2 of the cheetahs with the most severe abnormal tau immunoreactivity showed clinical cognitive dysfunction. The authors conclude that cheetahs spontaneously develop age-related neurodegenerative disease with pathologic changes similar to Alzheimer disease.

Structural and Chemical Studies of Pathological Fibers in Human Neurofibrillary Degeneration

1985 ◽  
Vol 43 ◽  
pp. 726-729
Author(s):  
K.S. Kosik ◽  
L.K. Duffy ◽  
S. Bakalis ◽  
C. Abraham ◽  
D.J. Selkoe
Keyword(s):  
Monoclonal Antibodies ◽  
Alzheimer Disease ◽  
Human Brain ◽  
Neurofibrillary Tangles ◽  
Morphological Analysis ◽  
High Specificity ◽  
Cytoskeletal Proteins ◽  
Neuritic Plaque ◽  
Protein Chemistry ◽  
Chemical Studies

The major structural lesions of the human brain during aging and in Alzheimer disease (AD) are the neurofibrillary tangles (NFT) and the senile (neuritic) plaque. Although these fibrous alterations have been recognized by light microscopists for almost a century, detailed biochemical and morphological analysis of the lesions has been undertaken only recently. Because the intraneuronal deposits in the NFT and the plaque neurites and the extraneuronal amyloid cores of the plaques have a filamentous ultrastructure, the neuronal cytoskeleton has played a prominent role in most pathogenetic hypotheses.The approach of our laboratory toward elucidating the origin of plaques and tangles in AD has been two-fold: the use of analytical protein chemistry to purify and then characterize the pathological fibers comprising the tangles and plaques, and the use of certain monoclonal antibodies to neuronal cytoskeletal proteins that, despite high specificity, cross-react with NFT and thus implicate epitopes of these proteins as constituents of the tangles.

Transglutaminases: Protein Cross-Linking Enzymes in Tissues and Body Fluids

1994 ◽  
Vol 71 (04) ◽  
pp. 402-415 ◽  
Author(s):  
Daniel Aeschlimann ◽  
Mats Paulsson
Keyword(s):  
Body Fluids ◽  
Cross Linking ◽  
Protein Cross Linking

Tridegin, a Novel Peptidic Inhibitor of Factor XIIIa from the Leech, Haementeria ghilianii, Enhances Fibrinolysis In Vitro

1997 ◽  
Vol 77 (05) ◽  
pp. 0959-0963 ◽  
Author(s):  
Lisa Seale ◽  
Sarah Finney ◽  
Roy T Sawyer ◽  
Robert B Wallis
Keyword(s):  
Potent Inhibitor ◽  
Platelet Rich Plasma ◽  
Factor Xiiia ◽  
Cross Linking ◽  
Fibrinolytic Enzymes ◽  
Small Polypeptide ◽  
Tissue Plasminogen ◽  
Protein Cross Linking

SummaryTridegin is a potent inhibitor of factor Xllla from the leech, Haementeria ghilianii, which inhibits protein cross-linking. It modifies plasmin-mediated fibrin degradation as shown by the absence of D-dimer and approximately halves the time for fibrinolysis. Plasma clots formed in the presence of Tridegin lyse more rapidly when either streptokinase, tissue plasminogen activator or hementin is added 2 h after clot formation. The effect of Tridegin is markedly increased if clots are formed from platelet-rich plasma. Platelet-rich plasma clots are lysed much more slowly by the fibrinolytic enzymes used and if Tridegin is present, the rate of lysis returns almost to that of platelet- free clots. These studies indicate the important role of platelets in conferring resistance to commonly used fibrinolytic enzymes and suggest that protein cross-linking is an important step in this effect. Moreover they indicate that Tridegin, a small polypeptide, may have potential as an adjunct to thrombolytic therapy.

scholarly journals Glycan-protein cross-linking mass spectrometry reveals sialic acid-mediated protein networks on cell surfaces

2021 ◽  
Author(s):  
Yixuan Xie ◽  
Siyu Chen ◽  
Qiongyu Li ◽  
Ying Sheng ◽  
Michael R Alvarez ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Sialic Acid ◽  
Membrane Proteins ◽  
Cell Membranes ◽  
Sialic Acids ◽  
Cross Linking ◽  
Protein Networks ◽  
Cell Surfaces ◽  
Protein Cross Linking

A cross-linking method is developed to elucidate the glycan-mediated interactions between membrane proteins through sialic acids. The method provides previously unknown extensive glycomic interactions on cell membranes. The vast majority...

Effect of protein cross-linking aldehydes on nerve activity

1981 ◽  
Vol 89 (2) ◽  
pp. 159-165 ◽  
Author(s):  
D. G. Margineanu ◽  
Eva Katona ◽  
Junona Popa
Keyword(s):  
Cross Linking ◽  
Nerve Activity ◽  
Protein Cross Linking

A Novel Protein Cross-Linking Reaction in Stressed Neutral Protamine Hagedorn Formulations of Insulin

1999 ◽  
Vol 88 (3) ◽  
pp. 331-336 ◽  
Author(s):  
Ronald C. Beavis ◽  
Michael D. Kneirman ◽  
David Sharknas ◽  
Mark A. Heady ◽  
Bruce H. Frank ◽  
...  
Keyword(s):  
Cross Linking ◽  
Neutral Protamine Hagedorn ◽  
Novel Protein ◽  
Protein Cross Linking

scholarly journals Model of the Mediator middle module based on protein cross-linking

2013 ◽  
Vol 41 (20) ◽  
pp. 9266-9273 ◽  
Author(s):  
Laurent Larivière ◽  
Clemens Plaschka ◽  
Martin Seizl ◽  
Evgeniy V. Petrotchenko ◽  
Larissa Wenzeck ◽  
...  
Keyword(s):  
Cross Linking ◽  
Protein Cross Linking
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