Reappraisal of the fine structure of Alzheimer's neurofibrillary tangles

1981 ◽  
Vol 54 (3) ◽  
pp. 239-246 ◽  
Author(s):  
S. Yagishita ◽  
Y. Itoh ◽  
Wang Nan ◽  
N. Amano
Keyword(s):  
Fine Structure ◽  
Neurofibrillary Tangles ◽  
Alzheimer's Neurofibrillary Tangles

scholarly journals Cucumber Shaped and 35 nm Particles in Creutzfeldt-Jakob Disease

1975 ◽  
Vol 2 (3) ◽  
pp. 203-207 ◽  
Author(s):  
Dikran S. Horoupian ◽  
R.T. Ross
Keyword(s):  
Neurofibrillary Tangles ◽  
Amyloid Plaques ◽  
Jakob Disease ◽  
Alzheimer's Neurofibrillary Tangles

SUMMARY:A 63 year old female with the ataxic form of Creutzfeldt-Jakob disease (CJD) is presented. In addition to amyloid plaques which were not associated with Alzheimer’s neurofibrillary tangles, rare profiles similar to those reported in Scrapie were also seen. To our knowledge, these profiles have never been observed in CJD and their presence in this condition adds a further morphologic similarity between the human and animal forms of subacute spongiform “viral” encephalopathies.

The fine structure of dementing illness: Alzheimer's disease and AIDS

1987 ◽  
Vol 45 ◽  
pp. 612-615
Author(s):  
S. S. Mirra ◽  
M. L. Miles ◽  
C. del Rio ◽  
M. H. Ellisman
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Fine Structure ◽  
Neurofibrillary Tangles ◽  
Brain Biopsy ◽  
Paired Helical Filaments ◽  
Apical Dendrite ◽  
Voltage Electron ◽  
Electron Microscopes ◽  
Axonal Protein

Electron microscopy has made important contributions to our understanding of dementing illnesses. The fine structure of neurofibrillary tangles and neuritic plaques, the pathologic hallmarks of Alzheimer's disease, was first described in the early 1960's. Yet, the nature of paired helical filaments, constituents of neurofibrillary tangles and some plaque neurites, has remained an enigma. Recent studies indicate that a major component of paired helical filaments is an atypically phosphorylated form of the microtubule-associated protein, tau. The finding of tau, normally an axonal protein, within neurofibrillary tangles of cell body and apical dendrite suggests that abnormalities in segregation and modification of this microtubule-associated protein may be defective in Alzheimer's disease.The availability of brain biopsy specimens from five cases of neuropathologically confirmed Alzheimer's disease provided the opportunity for study of well-preserved tissue. Thin and thick sections (0.25-0.75 um) viewed on conventional and high voltage electron microscopes revealed sidearms or extensions projecting at irregular intervals along the paired helical filaments.

The fine structure of subcortical neurofibrillary tangles in progressive supranuclear palsy

1979 ◽  
Vol 45 (2) ◽  
pp. 147-152 ◽  
Author(s):  
O. Bugiani ◽  
G. L. Mancardi ◽  
A. Brusa ◽  
A. Ederli
Keyword(s):  
Fine Structure ◽  
Progressive Supranuclear Palsy ◽  
Neurofibrillary Tangles

Gerstmann-Str�ussler syndrome ? A variant type: amyloid plaques and Alzheimer's neurofibrillary tangles in cerebral cortex

1992 ◽  
Vol 84 (1) ◽  
pp. 15-23 ◽  
Author(s):  
Naoji Amano ◽  
Saburo Yagishita ◽  
Susumu Yokoi ◽  
Yoji Itoh ◽  
Jun Kinoshita ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Neurofibrillary Tangles ◽  
Amyloid Plaques ◽  
Variant Type ◽  
Alzheimer's Neurofibrillary Tangles
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