The fine structure of subcortical neurofibrillary tangles in progressive supranuclear palsy

1979 ◽  
Vol 45 (2) ◽  
pp. 147-152 ◽  
Author(s):  
O. Bugiani ◽  
G. L. Mancardi ◽  
A. Brusa ◽  
A. Ederli
Keyword(s):  
Fine Structure ◽  
Progressive Supranuclear Palsy ◽  
Neurofibrillary Tangles

The fine structure of dementing illness: Alzheimer's disease and AIDS

1987 ◽  
Vol 45 ◽  
pp. 612-615
Author(s):  
S. S. Mirra ◽  
M. L. Miles ◽  
C. del Rio ◽  
M. H. Ellisman
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Fine Structure ◽  
Neurofibrillary Tangles ◽  
Brain Biopsy ◽  
Paired Helical Filaments ◽  
Apical Dendrite ◽  
Voltage Electron ◽  
Electron Microscopes ◽  
Axonal Protein

Electron microscopy has made important contributions to our understanding of dementing illnesses. The fine structure of neurofibrillary tangles and neuritic plaques, the pathologic hallmarks of Alzheimer's disease, was first described in the early 1960's. Yet, the nature of paired helical filaments, constituents of neurofibrillary tangles and some plaque neurites, has remained an enigma. Recent studies indicate that a major component of paired helical filaments is an atypically phosphorylated form of the microtubule-associated protein, tau. The finding of tau, normally an axonal protein, within neurofibrillary tangles of cell body and apical dendrite suggests that abnormalities in segregation and modification of this microtubule-associated protein may be defective in Alzheimer's disease.The availability of brain biopsy specimens from five cases of neuropathologically confirmed Alzheimer's disease provided the opportunity for study of well-preserved tissue. Thin and thick sections (0.25-0.75 um) viewed on conventional and high voltage electron microscopes revealed sidearms or extensions projecting at irregular intervals along the paired helical filaments.

Reappraisal of the fine structure of Alzheimer's neurofibrillary tangles

1981 ◽  
Vol 54 (3) ◽  
pp. 239-246 ◽  
Author(s):  
S. Yagishita ◽  
Y. Itoh ◽  
Wang Nan ◽  
N. Amano
Keyword(s):  
Fine Structure ◽  
Neurofibrillary Tangles ◽  
Alzheimer's Neurofibrillary Tangles
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