Distribution and ultrastructure of Alzheimer's neurofibrillary tangles in postencephalitic parkinsonism of Economo type

1981 ◽  
Vol 55 (1) ◽  
pp. 59-62 ◽  
Author(s):  
T. Ishii ◽  
Y. Nakamura
Keyword(s):  
Neurofibrillary Tangles ◽  
Postencephalitic Parkinsonism ◽  
Alzheimer's Neurofibrillary Tangles

scholarly journals Tauopathies: A Distinct Class of Neurodegenerative Diseases

2007 ◽  
Vol 10 (2) ◽  
pp. 3-14 ◽  
Author(s):  
M Ozansoy ◽  
A Başak
Keyword(s):  
Neurodegenerative Diseases ◽  
Neurofibrillary Tangles ◽  
Neuronal Loss ◽  
Corticobasal Degeneration ◽  
Chromosome 17 ◽  
Cell Degeneration ◽  
Distinct Class ◽  
Postencephalitic Parkinsonism ◽  
Tau Isoforms ◽  
Niemann Pick

Tauopathies: A Distinct Class of Neurodegenerative DiseasesNeurodegenerative diseases are characterized by neuronal loss and intraneuronal accumulation of fibrillary materials, of which, neurofibrillary tangles (NFT) are the most common. Neurofibrillary tangles also occur in normal aging and contain the hyperphosphorylated microtubule-associated protein tau. A detailed presentation is made of the molecular bases of Alzheimer's disease (AD), postencephalitic parkinsonism, amyotrophic lateral sclerosis/parkinsonism-dementia complex (ALS/PDC) of Guam, progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), Pick's disease, frontotemporal dementia (FTD), Down's syndrome, myotonic dystrophy (DM) and Niemann-Pick Type C (NPC) disease, which are considered to be common tauopathies. The unique human tau gene extends over 100 kb of the long arm of chromosome 17 and contains 16 exons. The human brain contains six tau isoforms that contain from 352 to 441 amino acids. To date, 34 pathogenic tau mutations have been described among 101 families affected by FTD with parkinsonism linked to chromosome 17 (FTDP-17). These mutations may involve alternative splicing of exon 10 that lead to changes in the proportion of 4-repeat- and 3-repeat-tau isoforms, or may modify tau interactions with microtubules. Tau aggregates differ in degree of phosphorylation and in content of tau isoforms. Five classes of tauopathies have been defined depending on the type of tau aggregates. The key event in tauopathies is the disorganization of the cytoskeleton, which is based on mutations/polymorphisms in the tau gene and lead to nerve cell degeneration. In this review, tauopathies as a distinct class of neurodegenerative diseases are discussed with emphasis on their molecular pathology and genetics.

scholarly journals Cucumber Shaped and 35 nm Particles in Creutzfeldt-Jakob Disease

1975 ◽  
Vol 2 (3) ◽  
pp. 203-207 ◽  
Author(s):  
Dikran S. Horoupian ◽  
R.T. Ross
Keyword(s):  
Neurofibrillary Tangles ◽  
Amyloid Plaques ◽  
Jakob Disease ◽  
Alzheimer's Neurofibrillary Tangles

SUMMARY:A 63 year old female with the ataxic form of Creutzfeldt-Jakob disease (CJD) is presented. In addition to amyloid plaques which were not associated with Alzheimer’s neurofibrillary tangles, rare profiles similar to those reported in Scrapie were also seen. To our knowledge, these profiles have never been observed in CJD and their presence in this condition adds a further morphologic similarity between the human and animal forms of subacute spongiform “viral” encephalopathies.

An autopsy case of postencephalitic parkinsonism of von Economo type: Some new observations concerning neurofibrillary tangles and astrocytic tangles

2000 ◽  
Vol 20 (2) ◽  
pp. 143-148 ◽  
Author(s):  
Takashi Haraguchi ◽  
Hideki Ishizu ◽  
Seishi Terada ◽  
Yasushi Takehisa ◽  
Yasuyuki Tanabe ◽  
...  
Keyword(s):  
Neurofibrillary Tangles ◽  
Autopsy Case ◽  
Postencephalitic Parkinsonism

Reappraisal of the fine structure of Alzheimer's neurofibrillary tangles

1981 ◽  
Vol 54 (3) ◽  
pp. 239-246 ◽  
Author(s):  
S. Yagishita ◽  
Y. Itoh ◽  
Wang Nan ◽  
N. Amano
Keyword(s):  
Fine Structure ◽  
Neurofibrillary Tangles ◽  
Alzheimer's Neurofibrillary Tangles

Gerstmann-Str�ussler syndrome ? A variant type: amyloid plaques and Alzheimer's neurofibrillary tangles in cerebral cortex

1992 ◽  
Vol 84 (1) ◽  
pp. 15-23 ◽  
Author(s):  
Naoji Amano ◽  
Saburo Yagishita ◽  
Susumu Yokoi ◽  
Yoji Itoh ◽  
Jun Kinoshita ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Neurofibrillary Tangles ◽  
Amyloid Plaques ◽  
Variant Type ◽  
Alzheimer's Neurofibrillary Tangles
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