Antineoplastic action ofp-(3-methyl-1-triazeno)benzoic acid potassium salt, a monomethyl derivative of the antimetastatic compound DM-COOK

1991 ◽  
Vol 27 (6) ◽  
pp. 423-428
Author(s):  
Gianni Sava ◽  
Sonia Zorzet ◽  
Laura Perissin ◽  
Sabrina Pacor ◽  
Lucia Lassiani ◽  
...  
Keyword(s):  
Benzoic Acid ◽  
Potassium Salt ◽  
Antineoplastic Action

Mutagenic activity of the dacarbazine analog p-(3,3-dimethyl-l-triazeno)benzoic acid potassium salt in bacterial cells

1986 ◽  
Vol 18 (5) ◽  
pp. 491-501 ◽  
Author(s):  
Marisa Tamaro ◽  
Lucilla Dolzani ◽  
Carlo Monti-bragadin ◽  
Gianni Sava
Keyword(s):  
Benzoic Acid ◽  
Potassium Salt ◽  
Mutagenic Activity ◽  
Bacterial Cells

Synthesis and Characterization of New Dibenzo[b, e]Thiepine Derivatives. I

2009 ◽  
Vol 59 (12) ◽  
Author(s):  
Camelia Elena Stecoza ◽  
Miron Teodor Caproiu ◽  
Constantin Draghici ◽  
Corina Ilie ◽  
Ileana Cornelia Chirita
Keyword(s):  
Hydrogen Peroxide ◽  
Spectral Analysis ◽  
Benzoic Acid ◽  
Potassium Salt ◽  
Polyphosphoric Acid ◽  
Chemical Characterization ◽  
Synthesis And Characterization ◽  
Acid Chlorides ◽  
New Compounds

The aim of the present paper was the synthesis and chemical characterization of some original compounds with dibenzo[b,e]thiepine structure. The synthesis of the new compounds was performed in several stages. Thus, by reaction of phtalide with thiophenol potassium salt, we obtained the 2-phenylthiomethyl-benzoic acid. The acid was cyclized with polyphosphoric acid to the desired 6,11-dihydrodibenzo[b,e]thiepin-11(6H)-one, converted afterwards to the corresponding oxime and subsequently to the O-acyloximino-dibenzo[b,e]thiepins by acylation with various substituted benzoic acid chlorides. The oxidation of O-acyloximino-dibenzo[b,e]thiepins with hydrogen peroxide afforded the corresponding sulfones. The new compounds, four O-acyl-oximino-dibenzo[b,e]thiepins, and four O-acyl-oximino-dibenzo[b,e]thiepin-5,5-dioxides, have been characterized by their physical constants (melting point, solubility) and their structures and purity were confirmed by elemental analysis, and spectral analysis (IR, 1H-NMR, 13C-NMR).

Effects of p-(3,3-dimethyl-1-triazeno)benzoic acid potassium salt on leukemic infiltration of brain and liver in mice bearing P388 leukemia

1984 ◽  
Vol 20 (2) ◽  
pp. 287-289 ◽  
Author(s):  
Gianni Sava ◽  
Tullio Giraldi ◽  
Fiora Bartoli-Klugmann ◽  
Giuliana Decorti ◽  
Franco Mallardi
Keyword(s):  
Benzoic Acid ◽  
Potassium Salt ◽  
Leukemic Infiltration ◽  
P388 Leukemia

ChemInform Abstract: Synthesis and Antitumor Activity of Hydrosoluble Analogs of p-(3,3-Dimethyl-1-triazeno)benzoic Acid Potassium Salt.

ChemInform ◽  
2010 ◽  
Vol 23 (20) ◽  
pp. no-no
Author(s):  
A. VARNAVAS ◽  
C. NISI ◽  
L. LASSIANI ◽  
G. SAVA ◽  
L. PERISSIN ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Benzoic Acid ◽  
Potassium Salt

Cytogenetic effects of 1-p-(3-methyltriazeno)benzoic acid potassium salt on human lymphocytes in vitro

1987 ◽  
Vol 189 (3) ◽  
pp. 349-356 ◽  
Author(s):  
P. Vernole ◽  
D. Caporossi ◽  
B. Tedeschi ◽  
B. Porfirio ◽  
G. Melino ◽  
...  
Keyword(s):  
Benzoic Acid ◽  
Potassium Salt ◽  
Human Lymphocytes ◽  
Cytogenetic Effects

Sister-chromatid exchanges in human lymphocytes exposed to 1-p-(3-methyltriazeno)benzoic acid potassium salt

1988 ◽  
Vol 208 (3-4) ◽  
pp. 233-236 ◽  
Author(s):  
P. Vernole ◽  
D. Caporossi ◽  
B. Tedeschi ◽  
G. Melino ◽  
B. Porfirio ◽  
...  
Keyword(s):  
Benzoic Acid ◽  
Sister Chromatid ◽  
Potassium Salt ◽  
Human Lymphocytes ◽  
Sister Chromatid Exchanges ◽  
Chromatid Exchanges

TEM characterization of proton-exchanged LiNbO3 optical waveguides

1986 ◽  
Vol 44 ◽  
pp. 480-481
Author(s):  
W. E. Lee
Keyword(s):  
Refractive Index ◽  
Benzoic Acid ◽  
Optical Waveguides ◽  
Total Internal Reflection ◽  
Index Of Refraction ◽  
Optical Measurements ◽  
Lithium Ions ◽  
Wide Channel ◽  
Tem Characterization

An optical waveguide consists of a several-micron wide channel with a slightly different index of refraction than the host substrate; light can be trapped in the channel by total internal reflection.Optical waveguides can be formed from single-crystal LiNbO3 using the proton exhange technique. In this technique, polished specimens are masked with polycrystal1ine chromium in such a way as to leave 3-13 μm wide channels. These are held in benzoic acid at 249°C for 5 minutes allowing protons to exchange for lithium ions within the channels causing an increase in the refractive index of the channel and creating the waveguide. Unfortunately, optical measurements often reveal a loss in waveguiding ability up to several weeks after exchange.

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