ChemInform Abstract: Synthesis and Antitumor Activity of Hydrosoluble Analogs of p-(3,3-Dimethyl-1-triazeno)benzoic Acid Potassium Salt.

ChemInform ◽  
2010 ◽  
Vol 23 (20) ◽  
pp. no-no
Author(s):  
A. VARNAVAS ◽  
C. NISI ◽  
L. LASSIANI ◽  
G. SAVA ◽  
L. PERISSIN ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Benzoic Acid ◽  
Potassium Salt

Mutagenic activity of the dacarbazine analog p-(3,3-dimethyl-l-triazeno)benzoic acid potassium salt in bacterial cells

1986 ◽  
Vol 18 (5) ◽  
pp. 491-501 ◽  
Author(s):  
Marisa Tamaro ◽  
Lucilla Dolzani ◽  
Carlo Monti-bragadin ◽  
Gianni Sava
Keyword(s):  
Benzoic Acid ◽  
Potassium Salt ◽  
Mutagenic Activity ◽  
Bacterial Cells

Synthesis and Characterization of New Dibenzo[b, e]Thiepine Derivatives. I

2009 ◽  
Vol 59 (12) ◽  
Author(s):  
Camelia Elena Stecoza ◽  
Miron Teodor Caproiu ◽  
Constantin Draghici ◽  
Corina Ilie ◽  
Ileana Cornelia Chirita
Keyword(s):  
Hydrogen Peroxide ◽  
Spectral Analysis ◽  
Benzoic Acid ◽  
Potassium Salt ◽  
Polyphosphoric Acid ◽  
Chemical Characterization ◽  
Synthesis And Characterization ◽  
Acid Chlorides ◽  
New Compounds

The aim of the present paper was the synthesis and chemical characterization of some original compounds with dibenzo[b,e]thiepine structure. The synthesis of the new compounds was performed in several stages. Thus, by reaction of phtalide with thiophenol potassium salt, we obtained the 2-phenylthiomethyl-benzoic acid. The acid was cyclized with polyphosphoric acid to the desired 6,11-dihydrodibenzo[b,e]thiepin-11(6H)-one, converted afterwards to the corresponding oxime and subsequently to the O-acyloximino-dibenzo[b,e]thiepins by acylation with various substituted benzoic acid chlorides. The oxidation of O-acyloximino-dibenzo[b,e]thiepins with hydrogen peroxide afforded the corresponding sulfones. The new compounds, four O-acyl-oximino-dibenzo[b,e]thiepins, and four O-acyl-oximino-dibenzo[b,e]thiepin-5,5-dioxides, have been characterized by their physical constants (melting point, solubility) and their structures and purity were confirmed by elemental analysis, and spectral analysis (IR, 1H-NMR, 13C-NMR).

Effects of p-(3,3-dimethyl-1-triazeno)benzoic acid potassium salt on leukemic infiltration of brain and liver in mice bearing P388 leukemia

1984 ◽  
Vol 20 (2) ◽  
pp. 287-289 ◽  
Author(s):  
Gianni Sava ◽  
Tullio Giraldi ◽  
Fiora Bartoli-Klugmann ◽  
Giuliana Decorti ◽  
Franco Mallardi
Keyword(s):  
Benzoic Acid ◽  
Potassium Salt ◽  
Leukemic Infiltration ◽  
P388 Leukemia

SN2-Type Glycosylation with Unprotected Pyranoses

2019 ◽  
Author(s):  
Hironori Takeuchi ◽  
Yusuke Fujimori ◽  
Hiromitsu Shibayama ◽  
Masaru Nagaishi ◽  
Yoshihiro Ueda ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Antitumor Activity ◽  
Benzoic Acid ◽  
Total Synthesis ◽  
Carboxylic Acids ◽  
Stereoselective Glycosylation ◽  
Wide Range ◽  
High Stereoselectivity ◽  
Glycosyl Donors

<p>An SN2 mechanism was proposed for highly stereoselective glycosylation of benzoic acid with unprotected α-D-glucose under Mitsunobu conditions in dioxane, while an SN1 mechanism seems to be responsible for non-stereoselective glycosylation in DMF. The SN2-type glycosylation can be applicable to various unprotected pyranoses as glycosyl donors and a wide range of carboxylic acids, phenols, and imides as glycosyl acceptors, retaining its high stereoselectivity (34 examples). Glycosylation of a carboxylic acid with unprotected α-D-mannose proceeded also in an SN2 manner to directly afford a usually less accessible 1,2-<i>cis</i>-mannoside. An extremely short-step total synthesis of a middle molecule (1874 Da) natural glycoside with antitumor activity, coriariin A, was achieved via a double SN2 glycosylation strategy with two molecules of unprotected α-D-glucose.</p>

Cytogenetic effects of 1-p-(3-methyltriazeno)benzoic acid potassium salt on human lymphocytes in vitro

1987 ◽  
Vol 189 (3) ◽  
pp. 349-356 ◽  
Author(s):  
P. Vernole ◽  
D. Caporossi ◽  
B. Tedeschi ◽  
B. Porfirio ◽  
G. Melino ◽  
...  
Keyword(s):  
Benzoic Acid ◽  
Potassium Salt ◽  
Human Lymphocytes ◽  
Cytogenetic Effects

Antineoplastic action ofp-(3-methyl-1-triazeno)benzoic acid potassium salt, a monomethyl derivative of the antimetastatic compound DM-COOK

1991 ◽  
Vol 27 (6) ◽  
pp. 423-428
Author(s):  
Gianni Sava ◽  
Sonia Zorzet ◽  
Laura Perissin ◽  
Sabrina Pacor ◽  
Lucia Lassiani ◽  
...  
Keyword(s):  
Benzoic Acid ◽  
Potassium Salt ◽  
Antineoplastic Action

SN2-Type Glycosylation with Unprotected Pyranoses

2019 ◽  
Author(s):  
Hironori Takeuchi ◽  
Yusuke Fujimori ◽  
Hiromitsu Shibayama ◽  
Masaru Nagaishi ◽  
Yoshihiro Ueda ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Antitumor Activity ◽  
Benzoic Acid ◽  
Total Synthesis ◽  
Carboxylic Acids ◽  
Stereoselective Glycosylation ◽  
Wide Range ◽  
High Stereoselectivity ◽  
Glycosyl Donors

<p>An SN2 mechanism was proposed for highly stereoselective glycosylation of benzoic acid with unprotected α-D-glucose under Mitsunobu conditions in dioxane, while an SN1 mechanism seems to be responsible for non-stereoselective glycosylation in DMF. The SN2-type glycosylation can be applicable to various unprotected pyranoses as glycosyl donors and a wide range of carboxylic acids, phenols, and imides as glycosyl acceptors, retaining its high stereoselectivity (34 examples). Glycosylation of a carboxylic acid with unprotected α-D-mannose proceeded also in an SN2 manner to directly afford a usually less accessible 1,2-<i>cis</i>-mannoside. An extremely short-step total synthesis of a middle molecule (1874 Da) natural glycoside with antitumor activity, coriariin A, was achieved via a double SN2 glycosylation strategy with two molecules of unprotected α-D-glucose.</p>

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