Evaluation of the mechanical behavior of compact deproteinized and demineralized bone tissue under tension

1983 ◽  
Vol 18 (6) ◽  
pp. 719-725 ◽  
Author(s):  
M. A. Dobelis ◽  
A. �. Melnis
Keyword(s):  
Mechanical Behavior ◽  
Bone Tissue ◽  
Demineralized Bone

In-depth gaze at the astonishing mechanical behavior of bone: A review for designing bio-inspired hierarchical metamaterials

2020 ◽  
pp. 108128652097851
Author(s):  
Ivan Giorgio ◽  
Mario Spagnuolo ◽  
Ugo Andreaus ◽  
Daria Scerrato ◽  
Alberto Maria Bersani
Keyword(s):  
Structural Optimization ◽  
Mechanical Behavior ◽  
Bone Tissue ◽  
Hierarchical Structure ◽  
Reconstructive Surgery ◽  
Review Paper ◽  
Tissue Mechanics ◽  
The Hierarchical Structure ◽  
Mechanical Models ◽  
Different Levels

In this review paper, some relevant models, algorithms, and approaches conceived to describe the bone tissue mechanics and the remodeling process are showcased. Specifically, we briefly describe the hierarchical structure of the bone at different levels and underline the geometrical substructure characterizing the bone itself. The mechanical models adopted to describe the bone tissue at different levels of observation are introduced in their essential aspects. Furthermore, the modeling of the evolution, including the growth and resorption of bone, is treated by analyzing the main approaches employed, namely the mechanical feedback concept and the structural optimization perspective. In this regard, the most prominent ways to model the biomechanical stimulus are summarized. The modeling of the interaction with prostheses or grafts commonly used in reconstructive surgery is also recalled. The main aim of this survey consists thereby in providing the appropriate knowledge to mimic the deeply structured hierarchy of the bone tissue for synthesizing innovative and highly performing bio-inspired metamaterials.

Bioactivity and Mechanical Behavior of Polymer-Hydroxyapatite Composite Biomaterials for Bone Tissue Engineering

2006 ◽  
Author(s):  
Kalpana S. Katti ◽  
Devendra Verma ◽  
Rahul Bhowmik ◽  
Dinesh R. Katti
Keyword(s):  
Tissue Engineering ◽  
Mechanical Behavior ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Mechanical Response ◽  
Ex Situ ◽  
Interfacial Behavior ◽  
Composite Scaffolds ◽  
Composite Systems

Achieving optimal mechanical strength of scaffolds is the key issue in bone tissue engineering. We describe a biomimetic route for design of composites of polymers (polyacrylic acid (PAAc) and polycaprolactone (PCL)) and hydroxyapatite (HAP). The mineral polymer interfaces have a significant role on mechanical behavior as well as bioactivity of the composite systems. We have used a combination of experimental (photoacoustic infrared spectroscopy) as well as modeling (molecular dynamics) techniques to evaluate the nature of interfaces in the composites. Porous composite scaffolds of in situ HAP with PCL are made. Our simulation studies indicate calcium bridging between COO− of PAAc and surface calcium of HAP as well as hydrogen bonding. These results are also supported by infrared spectroscopic studies. PAAc modified surfaces of in situ HAP influence the microstructure and mechanical response of porous composites. Significant differences are present in the mechanical response of in situ and ex situ composite scaffolds. In addition, the growth and mechanism of apatite growth in the in situ and ex situ composites is different. Bioactivity is measured by soaking composite scaffolds in simulated body fluid (SBF). Apatite growth in ex situ composites is primarily by heterogeneous nucleation and that in in situ is primarily by homogeneous nucleation. We also observe that apatite grown on in situ HAP/PCL composites from SBF exhibits higher elastic modulus and hardness. Thus, by influencing the interfacial behavior in bone biomaterials both mechanical response and bioactivity of the composite systems may be modified. The present study gives insight into the interfacial mechanisms responsible for mechanical response as well as bioactivity in biomaterials.

Multipotent adult progenitor cell-loaded demineralized bone matrix for bone tissue engineering

2013 ◽  
Vol 10 (4) ◽  
pp. 275-283 ◽  
Author(s):  
Peter Supronowicz ◽  
Elise Gill ◽  
Angelica Trujillo ◽  
Taili Thula ◽  
Rasa Zhukauskas ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Progenitor Cell ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Multipotent Adult Progenitor Cell ◽  
Demineralized Bone

Electrospun Poly(ε-Caprolactone)/Bovine Hydroxyapatite (BHA) Composite Nanofibers for Bone Tissue Engineering

2016 ◽  
Vol 720 ◽  
pp. 228-233 ◽  
Author(s):  
Memduh Kagan Keler ◽  
Sibel Daglilar ◽  
Oguzhan Gunduz
Keyword(s):  
Tissue Engineering ◽  
Mechanical Behavior ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Composite Nanofibers ◽  
Crystalline Polymer ◽  
Tissue Scaffolds ◽  
Bovine Hydroxyapatite ◽  
Degradation Properties ◽  
Composite Designs

Tissue engineering applications have opened a different future-promising era for critical injuries, defects and diseases. Bone tissue engineering is the part of tissue engineering which aims to stir up new practical bone re-formation via the interactive combination of biomaterials and cells. Poly (e-caprolactone) (PCL) is a unique semi crystalline polymer material which handles several important features such as biocompatibility, high biomedical durability and degradation properties. Bovine hydroxyapatite (BHA) is another biocompatible material which provides to get ultimate mechanical behavior in composite designs. Because of their high biocompatibility, PCL and BHA were integrated the electrospinning system together. The system was revised for multi-feeding needle equipment. Eight dissimilar tissue scaffolds were produced and investigated for this recent work.

scholarly journals Demineralized Bone Matrix Coating Si-Ca-P Ceramic Does Not Improve the Osseointegration of the Scaffold

Materials ◽  
2018 ◽  
Vol 11 (9) ◽  
pp. 1580 ◽  
Author(s):  
Andrés Parrilla-Almansa ◽  
Nuria García-Carrillo ◽  
Patricia Ros-Tárraga ◽  
Carlos Martínez ◽  
Francisco Martínez-Martínez ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Tissue ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Micro Ct ◽  
New Bone Formation ◽  
Implantation Time ◽  
Post Surgery ◽  
Tissue Responses ◽  
Demineralized Bone

The aim of this study was to manufacture and evaluate the effect of a biphasic calcium silicophosphate (CSP) scaffold ceramic, coated with a natural demineralized bone matrix (DBM), to evaluate the efficiency of this novel ceramic material in bone regeneration. The DBM-coated CSP ceramic was made by coating a CSP scaffold with gel DBM, produced by the partial sintering of different-sized porous granules. These scaffolds were used to reconstruct defects in rabbit tibiae, where CSP scaffolds acted as the control material. Micro-CT and histological analyses were performed to evaluate new bone formation at 1, 3, and 5 months post-surgery. The present research results showed a correlation among the data obtained by micro-CT and the histomorphological results, the gradual disintegration of the biomaterial, and the presence of free scaffold fragments dispersed inside the medullary cavity occupied by hematopoietic bone marrow over the 5-month study period. No difference was found between the DBM-coated and uncoated implants. The new bone tissue inside the implants increased with implantation time. Slightly less new bone formation was observed in the DBM-coated samples, but it was not statistically significant. Both the DBM-coated and the CSP scaffolds gave excellent bone tissue responses and good osteoconductivity.

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