Antigen-induced histamine release by penetration of egg albumin antigen through excised guinea pig skin

1981 ◽  
Vol 271 (3) ◽  
pp. 357-360 ◽  
Author(s):  
S. Yamamoto ◽  
I. Kimura ◽  
T. Numata ◽  
T. Yamura
Keyword(s):  
Guinea Pig ◽  
Histamine Release ◽  
Egg Albumin ◽  
Pig Skin

scholarly journals Evaluation of Antiasthamic Activity of Electrohomeopathy Formulation Pettorale on Experimental Animals

2021 ◽  
Vol 11 (6) ◽  
pp. 121-126
Author(s):  
Prasant Kumar Sabat
Keyword(s):  
Amino Acids ◽  
Guinea Pig ◽  
Histamine Release ◽  
Antibody Production ◽  
Eosinophil Count ◽  
Leukocyte Count ◽  
Experimental Models ◽  
Phytochemical Screening ◽  
Experimental Animals ◽  
Egg Albumin

Objective: The current study was planned to evaluate the antiasthamatic effect of Electrohomeopathic medicine Pettorale in various experimental models. Methods: The antiasthmatic activity of Electrohomeopathic medicine Pettorale was studied on different experimental animals like histamine induced bronchospasm in guinea pig, haloperidol induced catalepsy in rats, egg albumin induced paw anaphylaxis in rats and milk induced leukocytosis in mice. Conclusion: Preliminary phytochemical screening has revealed the presence of alkaloids, glycosides, carbohydrates, amino acids, proteins, steroids and terpenoids. Petorella exhibited best antihistaminic activity at the dose of 400 mg/kg.  It inhibited haloperidol-induced catalepsy, increased leukocyte count and increased eosinophil count due to milk allergen. Antiasthmatic activity of Pettorale may be possible due to the membrane stabilising potential, suppression of antibody production and inhibition of antigen induced histamine release. Keywords: Electrohomeopathy,   Pettorale, catalepsy, asthma, histamine

Epithelial modulation of allergen and drug effects in guinea pig airways

1992 ◽  
Vol 72 (5) ◽  
pp. 1953-1959 ◽  
Author(s):  
N. Grundstrom ◽  
E. G. Lindstrom ◽  
K. L. Axelsson ◽  
R. G. Andersson
Keyword(s):  
Guinea Pig ◽  
Histamine Release ◽  
Contractile Response ◽  
Muscle Tension ◽  
Drug Effects ◽  
Potassium Ions ◽  
Epithelial Damage ◽  
Egg Albumin

The effect of egg albumin (EA) challenge on tracheal tube preparations from sensitized guinea pigs was studied with regard to EA permeability, histamine release and penetrability, and the contractile response of the preparation. We used a plethysmographic method that allowed simultaneous measurement of changes in smooth muscle tension and collection of samples for determination of mediators. Our results clearly show that epithelial damage potentiates the contractile response to histamine, potassium ions, and acetylcholine. Epithelial damage did not alter the maximal contractile response in preparations challenged with high antigen concentrations (EA, 1 mg/ml), but histamine release measured in the perfusate increased substantially. The permeability of the preparations to EA was greater when the epithelium was damaged. No increase in the permeability in response to the EA challenge was observed. The present study has demonstrated that guinea pig airway epithelium constitutes a barrier for both antigen and drugs. We also present a method for recording contractile responses from intact whole tracheal preparations, in which the epithelium can still act as a barrier, as is the case in vivo.

scholarly journals Effects of epithelium on antigen-induced histamine release from guinea-pig isolated trachea

1990 ◽  
Vol 52 ◽  
pp. 306
Author(s):  
Katsuyoshi Sugizaki ◽  
Tomokazu Hosokawa ◽  
Yutaka Kasuya
Keyword(s):  
Guinea Pig ◽  
Histamine Release ◽  
Isolated Trachea

scholarly journals Cutaneous lipogenesis: precursors utilized by guinea pig skin for lipid synthesis

1971 ◽  
Vol 12 (3) ◽  
pp. 347-360
Author(s):  
VICTOR R. WHEATLEY ◽  
LEONARD T. HODGINS ◽  
WILLIAM M. COON ◽  
MUTUKUMARA KUMARASIRI ◽  
HAROLD BERENZWEIG ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Lipid Synthesis ◽  
Pig Skin

Final Report of the Safety Assessment of Kojic Acid as Used in Cosmetics

2010 ◽  
Vol 29 (6_suppl) ◽  
pp. 244S-273S ◽  
Author(s):  
Christina L. Burnett ◽  
Wilma F. Bergfeld ◽  
Donald V. Belsito ◽  
Ronald A. Hill ◽  
Curtis D. Klaassen ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Safety Assessment ◽  
Expert Panel ◽  
Kojic Acid ◽  
Tumor Promotion ◽  
Final Report ◽  
Cosmetic Products ◽  
Pig Skin ◽  
Animal Data ◽  
Skin Lightening

Kojic acid functions as an antioxidant in cosmetic products. Kojic acid was not a toxicant in acute, chronic, reproductive, and genotoxicity studies. While some animal data suggested tumor promotion and weak carcinogenicity, kojic acid is slowly absorbed into the circulation from human skin and likely would not reach the threshold at which these effects were seen. The available human sensitization data supported the safety of kojic acid at a use concentration of 2% in leave-on cosmetics. Kojic acid depigmented black guinea pig skin at a concentration of 4%, but this effect was not seen at 1%. The Cosmetic Ingredient Review (CIR) Expert Panel concluded that the 2 end points of concern, dermal sensitization and skin lightening, would not be seen at use concentrations below 1%; therefore, this ingredient is safe for use in cosmetic products up to that level.

Phospholipids (PL) in the Arthus reaction sites induced in guinea-pig skin

1994 ◽  
Vol 8 (1) ◽  
pp. 84
Author(s):  
T. Tachibana ◽  
S. Taniguchi ◽  
S. Imamura
Keyword(s):  
Guinea Pig ◽  
Arthus Reaction ◽  
Pig Skin
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