Effect of carbon disulphide intoxication on fecal excretion of end products of cholesterol metabolism

1977 ◽  
Vol 40 (4) ◽  
pp. 261-265 ◽  
Author(s):  
Teresa Wrońska-Nofer
Keyword(s):  
Cholesterol Metabolism ◽  
Carbon Disulphide ◽  
Fecal Excretion ◽  
End Products ◽  
Carbon Disulphide Intoxication

Effects of bile acids on fecal excretion of end products of cholesterol metabolism

1960 ◽  
Vol 199 (4) ◽  
pp. 736-740 ◽  
Author(s):  
William T. Beher ◽  
Gizella D. Baker ◽  
William L. Anthony
Keyword(s):  
Bile Acid ◽  
Bile Acids ◽  
Cholic Acid ◽  
Cholesterol Metabolism ◽  
Fecal Excretion ◽  
Liver Cholesterol ◽  
Hyodeoxycholic Acid ◽  
End Products ◽  
Tissue Cholesterol ◽  
Steroid Excretion

The influence of bile acids on liver cholesterol mobilization and on the excretion of fecal end products of cholesterol-4-C14 metabolism was studied in mice. Tissue cholesterol was elevated by feeding a fat-free diet containing cholesterol or cholesterol-4-C14. The mice were then divided into three groups: cholic acid treated, control and hyodeoxycholic acid treated. Fecal collections were made at intervals for 20 days, and steroids extracted and fractionated. The quantity of the sterol fractions and the C14 activity of the sterol and bile acid fractions were determined. Regression of hepatic cholesterol was followed at the same time intervals. Cholic acid inhibited liver cholesterol mobilization, while hyodeoxycholic acid effected a rapid regression of liver cholesterol to subnormal levels. Cholic acid depressed total steroid excretion, the depression occurring in the bile acid fraction; while excretion of fecal sterols remained relatively unaltered. Hyodeoxycholic acid greatly increased total steroid excretion. The increase was in the sterol fraction (95%), while bile acid excretion was depressed. These data indicate that bile acids are important factors in determining the rate and route of cholesterol metabolism.

Effect of Different Dietary Fats on the Fæcal End-Products of Cholesterol Metabolism

Nature ◽  
1957 ◽  
Vol 180 (4592) ◽  
pp. 923-924 ◽  
Author(s):  
H. GORDON ◽  
B. LEWIS ◽  
L. EALES ◽  
J. F. BROCK
Keyword(s):  
Cholesterol Metabolism ◽  
Dietary Fats ◽  
End Products

scholarly journals The role of cytochrome P-450 in cholesterol biogenesis and catabolism

1972 ◽  
Vol 128 (2) ◽  
pp. 237-242 ◽  
Author(s):  
Sandra D. Atkin ◽  
Eileen D. Palmer ◽  
P. D. English ◽  
B. Morgan ◽  
M. A. Cawthorne ◽  
...  
Keyword(s):  
Cholesterol Metabolism ◽  
Carbon Disulphide ◽  
Normal Serum ◽  
Liver Cholesterol ◽  
Drug Metabolizing Enzyme ◽  
Metabolizing Enzyme ◽  
Cytochrome P 450

1. Adjuvant-induced arthritis in rats is accompanied by a loss of activity of the drug-metabolizing enzyme system and a decrease in hepatic cytochrome P-450. 2. Arthritic rats have normal serum and liver cholesterol concentrations. 3. The rate of biogenesis of cholesterol in vivo and in vitro from either [14C]acetate or [14C]mevalonate in arthritic rats was the same as or greater than that found in control rats. 4. Treatment of rats with carbon disulphide (1ml/kg) resulted in a loss of drug-metabolizing-enzyme activity and increased cholesterol biogenesis. 5. The activity of cholesterol 7α-hydroxylase in adjuvant-induced arthritic rats did not differ significantly from that in control rats. 6. Rats fed with cholestyramine had an elevated hepatic cholesterol 7α-hydroxylase activity, but neither the concentration of cytochrome P-450 nor the activity of the drug-hydroxylating enzyme, aminopyrine demethylase, was affected. 7. The relationships between drug hydroxylation and cholesterol metabolism are discussed.

Effect of saturated and unsaturated fats on hepatic synthesis and biliary excretion of cholesterol by the rat

1959 ◽  
Vol 196 (3) ◽  
pp. 599-602 ◽  
Author(s):  
Jean D. Wilson ◽  
Marvin D. Siperstein
Keyword(s):  
Total Cholesterol ◽  
Rat Liver ◽  
Dietary Fat ◽  
Biliary Excretion ◽  
Cholesterol Synthesis ◽  
Corn Oil ◽  
Cholesterol Metabolism ◽  
Cholesterol Levels ◽  
End Products ◽  
Hepatic Synthesis

In an attempt to elucidate the mechanisms by which saturated and unsaturated fats influence cholesterol metabolism, cholesterol synthesis in rat liver slices and the excretion of cholesterol end products into the bile of rats was studied during variations in the type and quantity of dietary fat. Neither 30% lard nor 30% corn oil diets had any effect on either the excretion of total cholesterol-C14 end products or of cholesterol itself into bile. Furthermore, the feeding of lard or corn oil, at either the 10% or 30% level, had no effect on the rate of conversion of acetate or mevalonate to cholesterol. These studies are interpreted as suggesting that the effects of saturated and unsaturated fats on cholesterol levels in rats are mediated at some phase of cholesterol metabolism other than the hepatic synthesis or hepatic degradation and excretion of this sterol.

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