scholarly journals Advanced Glycation End Products(AGE) Inhibit Scavenger Receptor Class B type I-Mediated Reverse Cholesterol Transport: A New Crossroad of AGE to Cholesterol Metabolism.

2003 ◽  
Vol 10 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Nobutaka Ohgami ◽  
Akira Miyazaki ◽  
Masakazu Sakai ◽  
Akihiko Kuniyasu ◽  
Hitoshi Nakayama ◽  
...  
Keyword(s):  
Reverse Cholesterol Transport ◽  
Cholesterol Metabolism ◽  
Scavenger Receptor ◽  
Cholesterol Transport ◽  
Type I ◽  
Advanced Glycation ◽  
Scavenger Receptor Class ◽  
Glycation End Products ◽  
End Products ◽  
Class B

Quercetin induces the selective uptake of HDL-cholesterol via promoting SR-BI expression and the activation of the PPARγ/LXRα pathway

2018 ◽  
Vol 9 (1) ◽  
pp. 624-635 ◽  
Author(s):  
Kun Ren ◽  
Ting Jiang ◽  
Guo-Jun Zhao
Keyword(s):  
Reverse Cholesterol Transport ◽  
Scavenger Receptor ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Cholesterol Transport ◽  
Type I ◽  
Lipid Uptake ◽  
Scavenger Receptor Class ◽  
Class B ◽  
Selective Lipid Uptake

Reverse cholesterol transport (RCT) is the process to deliver cholesterol to the liver for further excretion and involves scavenger receptor class B type I (SR-BI)-mediated selective lipid uptake (SLU) from high-density lipoprotein cholesterol (HDL-C).

scholarly journals CD36, a Member of the Class B Scavenger Receptor Family, as a Receptor for Advanced Glycation End Products

2000 ◽  
Vol 276 (5) ◽  
pp. 3195-3202 ◽  
Author(s):  
Nobutaka Ohgami ◽  
Ryoji Nagai ◽  
Mamoru Ikemoto ◽  
Hiroyuki Arai ◽  
Akihiko Kuniyasu ◽  
...  
Keyword(s):  
Advanced Glycation End Products ◽  
Scavenger Receptor ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products ◽  
Class B ◽  
Receptor Family

Cholesterol Metabolism—Impacts on SARS-CoV-2 Infection Prognosis, Entry, and Antiviral Therapies

2020 ◽  
Author(s):  
Congwen Wei ◽  
Luming Wan ◽  
Yanhong Zhang ◽  
Chen Fan ◽  
Qiulin Yan ◽  
...  
Keyword(s):  
Cholesterol Metabolism ◽  
Scavenger Receptor ◽  
Hdl Cholesterol ◽  
Lung Cells ◽  
Type I ◽  
Antiviral Therapies ◽  
Scavenger Receptor Class ◽  
Global Pandemic ◽  
Class B ◽  
Clinically Significant

AbstractThe recently emerged pathogenic SARS-coronavirus 2 (SARS-CoV-2) has spread rapidly, leading to a global pandemic. In this study, we show that SARS-CoV-2 infection was associated with clinically significant lower level of HDL cholesterol (HDL-C), which can be used as indicators of disease severity and poor prognosis. Importantly, we found the spike protein of SARS-CoV-2 (SARS-2-S) bound to HDL. Antagonists of HDL receptor-Scavenger receptor class B type I (SR-B1), strongly inhibited SARS-CoV-2 infection. Notably, the lipids transfer function of SR-B1 was indispensable for this inhibition, offering explanations for the reduced serum HDL level observed in COVID-19 patients. Basing on findings here, we speculate that SR-B1-mediated pulmonary HDL-vitamin E uptake could participate in mediating SARS-CoV-2 infection of lung cells, and the unique expression profile of SR-B1 may also affect SARS-CoV-2 cell and tissue tropism. These findings might help to provide further insights into viral transmission, pathological characteristics and reveal therapeutic targets.Graphical Abstract

CD36, a Member of Class B Scavenger Receptor Family, Is a Receptor for Advanced Glycation End Products

2006 ◽  
Vol 947 (1) ◽  
pp. 350-355 ◽  
Author(s):  
NOBUTAKA OHGAMI ◽  
RYOJI NAGAI ◽  
MAMORU IKEMOTO ◽  
HIROYUKI ARAI ◽  
AKIHIKO KUNIYASU ◽  
...  
Keyword(s):  
Advanced Glycation End Products ◽  
Scavenger Receptor ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products ◽  
Class B ◽  
Receptor Family

scholarly journals Extracellular Disulfide Bonds Support Scavenger Receptor Class B Type I-Mediated Cholesterol Transport

Biochemistry ◽  
2011 ◽  
Vol 50 (28) ◽  
pp. 6245-6254 ◽  
Author(s):  
Gabriella A. Papale ◽  
Paul J. Hanson ◽  
Daisy Sahoo
Keyword(s):  
Disulfide Bonds ◽  
Scavenger Receptor ◽  
Cholesterol Transport ◽  
Type I ◽  
Scavenger Receptor Class ◽  
Class B
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