The bovine lactoferrin gene (LTF) maps to Chromosome 22 and syntenic group U12

1994 ◽  
Vol 5 (8) ◽  
pp. 486-489 ◽  
Author(s):  
M. Schwerin ◽  
S. Solinas Toldo ◽  
A. Eggen ◽  
R. Brunner ◽  
H. M. Seyfert ◽  
...  
Keyword(s):  
Chromosome 22 ◽  
Bovine Lactoferrin ◽  
Syntenic Group ◽  
Lactoferrin Gene

Bovine lactoferrin and its functions in animals -A review

2015 ◽  
Vol 36 (4) ◽  
Author(s):  
Rajan Sharma ◽  
Dibyendu Chakraborty ◽  
Parul Gupta
Keyword(s):  
Bos Taurus ◽  
Bovine Milk ◽  
Regulatory Elements ◽  
Bovine Lactoferrin ◽  
Milk Whey ◽  
Lactoferrin Gene ◽  
Exon 1 ◽  
Variable Content ◽  
Differential Gene ◽  
Strong Antimicrobial Activity

Lactoferrin (Lf) was discovered in 1939 as “red protein from milk whey”. Bovine lactoferrin (bLf) gene is located on <italic>Bos taurus</italic> autosome, long arm of chromosome no.22 (BTA 22q24) in cattle. Its size varies from 23-35kbp among different species. The lactoferrin gene consists of 17 exons and 16 introns ranging from 82bp (exon-1) to 225bp (exon-17). The presence of multiple regulatory elements within lactoferrin promoter contributes differential gene expression and variable content of lactoferrin in milk. The concentration of lactoferrin in normal bovine milk is about 0.02-0.2 mg/ml. The primary function of Lf lies in its role in iron metabolism including iron transport, storage and chelation. Lf exhibits strong antimicrobial activity against a broad spectrum of bacteria (gram-positive & negative), fungi, yeasts, viruses and parasites. Lf exerts bacteriostatic and bactericidal activity. Its main contribution to antiviral defence consists in its binding to the cell membrane glycosaminoglycan, thus lactoferrin prevents viruses from entering cells and infection is stopped at an early age. More than 140 SNPs in this gene have been identiûed. Such a high variability in Lactoferrin gene implies that it may be used as candidate gene for screening animals also a marker of milk yield.

Polymorphism within TATA-box of bovine lactoferrin gene and its association with performance traits in Holstein cattle

2012 ◽  
Vol 149 (3) ◽  
pp. 267-274 ◽  
Author(s):  
Tadeusz Zabolewicz ◽  
Paweł Brym ◽  
Kamil Olenski ◽  
Tomasz Suchocki ◽  
Tadeusz Malewski ◽  
...  
Keyword(s):  
Tata Box ◽  
Bovine Lactoferrin ◽  
Holstein Cattle ◽  
Performance Traits ◽  
Lactoferrin Gene

scholarly journals Detection and Characterization of PCR-SSCP Markers of the Bovine Lactoferrin Gene for Clinical Mastitis

2006 ◽  
Vol 19 (10) ◽  
pp. 1399-1403 ◽  
Author(s):  
Zhou Lei ◽  
Yuan-Yuan Yang ◽  
Zhong-Hao Li ◽  
Li-Juan Kong ◽  
Guan-Dong Xing ◽  
...  
Keyword(s):  
Clinical Mastitis ◽  
Bovine Lactoferrin ◽  
Lactoferrin Gene

Lactoferrin gene promoter variants and their association with clinical and subclinical mastitis in indigenous and crossbred cattle

2015 ◽  
Vol 18 (3) ◽  
pp. 465-471 ◽  
Author(s):  
A. Chopra ◽  
I.D. Gupta ◽  
A. Verma ◽  
A.K. Chakravarty ◽  
V. Vohra
Keyword(s):  
Regulatory Region ◽  
Gene Promoter ◽  
Subclinical Mastitis ◽  
Clinical Mastitis ◽  
North India ◽  
Bovine Lactoferrin ◽  
Crossbred Cattle ◽  
Single Nucleotide ◽  
Lactoferrin Gene ◽  
Karan Fries

Abstract Lactoferrin (Lf) gene promoter was screened for the presence of single nucleotide polymphism in indigenous and crossbred cattle from North India and to evaluate its association with Mastitis. Study revealed the presence of genetic variation in regulatory region of bovine Lactoferrin gene using PCR-RFLP technique. Three genotypes namely GG, GH and HH were identified. A single nucleotide change, from guanine to adenine at 25th position was found to be significantly associated (p<0.05) with clinical mastitis in indigenous Sahiwal and crossbred Karan Fries cattle maintained at organised herd of National Dairy Research Institute, Karnal. A non-significant association was observed between subclinical mastitis, somatic cell score (SCS), and GG genotype in Karan Fries cattle, however, a lower SCS was observed in animals having GG genotype. Overall a lower incidence of clinical mastitis was recorded in those animals having GG genotype of Lf in Sahiwal and Karan Fries (KF) cattle. The SNP identified in the promoter region may effect expression lactoferrin protein, which may lead to different levels of antibacterial and anti-inflammatory activity of Lf gene. Results from this study indicated the probable role played by Lactoferrin promoter to serve as candidate gene for mastitis susceptibility among indigenous and crossbred milch cattle.

scholarly journals Associations between bovine lactoferrin gene polymorphism and somatic cell count in milk

2012 ◽  
Vol 51 (No. 1) ◽  
pp. 14-20 ◽  
Author(s):  
K. Wojdak-Maksymiec ◽  
M. Kmiec ◽  
J. Ziemak
Keyword(s):  
Gene Polymorphism ◽  
Somatic Cell ◽  
Cell Count ◽  
Somatic Cell Count ◽  
Bovine Lactoferrin ◽  
Logarithmic Scale ◽  
Black And White ◽  
Holstein Friesian ◽  
Pcr Rflp ◽  
Lactoferrin Gene

The study included 124 Polish Black-and-White dairy cows of various share of the Holstein-Friesian (HF) breed. Lactoferrin (LTF) gene polymorphism was obtained with PCR-RFLP method using EcoRI enzyme. Two alleles of LTF, A and B, were found in the studied population. Their frequencies were 67.74% and 32.56%, respectively. The alleles controlled the occurrence of three genotypes: AA, BB and AB, of frequencies equal to 37.90%, 2.42% and 59.68%, respectively. It was established that statistically significant associations exist between the somatic cell count (SCC) and LTF genotype, lactation month and parity as well as the HF gene share. No significant association was found between somatic cell count and season. The highest somatic cell count (transformed to a logarithmic scale) was found in milk of the AB genotype, whereas the lowest one was found in cows of the AA genotype.

Study on the Polymorphism of Bovine Lactoferrin Gene and Its Relationship with Mastitis

2004 ◽  
Vol 15 (1) ◽  
pp. 67-76 ◽  
Author(s):  
Guo-Hua Li ◽  
Yuan Zhang ◽  
Dong-Xiao Sun ◽  
Ning Li
Keyword(s):  
Bovine Lactoferrin ◽  
Lactoferrin Gene
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