The distribution of nerve fibers showing substance P-like immunoreactivity in the conduction system of the bovine heart: dense innervation in the atrioventricular bundle

1989 ◽  
Vol 179 (5) ◽  
pp. 485-490 ◽  
Author(s):  
Sture Forsgren
Keyword(s):  
Substance P ◽  
Nerve Fibers ◽  
Conduction System ◽  
Bovine Heart ◽  
Atrioventricular Bundle

Immunocytochemical study of nerve fibers containing substance P in the junctional epithelium of rats

1996 ◽  
Vol 31 (3) ◽  
pp. 187-194 ◽  
Author(s):  
T. Tanaka ◽  
M. A. Kido ◽  
T. Ibuki ◽  
T. Yamaza ◽  
T. Kondo ◽  
...  
Keyword(s):  
Substance P ◽  
Nerve Fibers ◽  
Junctional Epithelium ◽  
Immunocytochemical Study

Morphological examination of the termination pattern of substance P-immunoreactive nerve fibers in human antral mucosa

2002 ◽  
Vol 107 (1-3) ◽  
pp. 79-86 ◽  
Author(s):  
Ann-Charlott Ericson ◽  
Stergios Kechagias ◽  
Gunilla Öqvist ◽  
Sven Erik Sjöstrand
Keyword(s):  
Substance P ◽  
Nerve Fibers ◽  
Antral Mucosa ◽  
Morphological Examination

scholarly journals Immunohistochemical evidence for the presence of a vasoactive intestinal peptide, neuropeptide Y and substance P in rat adrenal medulla after heat stress

2012 ◽  
Vol 64 (1) ◽  
pp. 7-13
Author(s):  
Dragana Petrovic-Kosanovic ◽  
Vesna Koko
Keyword(s):  
Heat Stress ◽  
Substance P ◽  
Neuropeptide Y ◽  
Vasoactive Intestinal Peptide ◽  
Adrenal Medulla ◽  
Chromaffin Cells ◽  
Ganglion Cells ◽  
Nerve Fibers ◽  
Acute Heat Stress ◽  
Immunohistochemical Evidence

Immunohistochemistry revealed the presence of VIP-, NPY- and SP-immunoreactivity in the rat adrenal medulla. VIP- and NPY-immunoreactivity was detected in chromaffin and ganglion cells and in nerve fibers, but SP-immunoreactivity was found only in chromaffin cells. After acute heat stress, VIP- and NPY- immunoreactivities in cells and nerve fibers were reduced, probably as a result of the release of these peptides with catecholamines. The absence of SP-immunoreactive ganglion cells in the adrenal medulla suggests that the SP-immunoreactive nerve fibers are extrinsic in origin.

Distribution of substance P and calcitonin gene-related peptide immunoreactive nerve fibers in the trachea of chronically hypoxic rats

1996 ◽  
Vol 39 (6) ◽  
pp. 335-339 ◽  
Author(s):  
T. Kusakabe ◽  
T. Kawakami ◽  
F.L. Powell ◽  
M.H. Ellisman ◽  
H. Sawada ◽  
...  
Keyword(s):  
Substance P ◽  
Calcitonin Gene Related Peptide ◽  
Nerve Fibers ◽  
Related Peptide ◽  
Calcitonin Gene

The spatial distribution and relative abundance of gap-junctional connexin40 and connexin43 correlate to functional properties of components of the cardiac atrioventricular conduction system

1993 ◽  
Vol 105 (4) ◽  
pp. 985-991 ◽  
Author(s):  
R.G. Gourdie ◽  
N.J. Severs ◽  
C.R. Green ◽  
S. Rothery ◽  
P. Germroth ◽  
...  
Keyword(s):  
Spatial Distribution ◽  
Relative Abundance ◽  
Atrioventricular Node ◽  
Conduction System ◽  
Atrioventricular Conduction ◽  
Purkinje Fibre ◽  
Purkinje Fibres ◽  
Atrioventricular Bundle ◽  
Junctional Protein ◽  
Gap Junctional

Electrical coupling between heart muscle cells is mediated by specialised regions of sarcolemmal interaction termed gap junctions. In previous work, we have demonstrated that connexin42, a recently identified gap-junctional protein, is present in the specialised conduction tissues of the avian heart. In the present study, the spatial distribution of the mammalian homologue of this protein, connexin40, was examined using immunofluorescence, confocal scanning laser microscopy and quantitative digital image analysis in order to determine whether a parallel distribution occurs in rat. Connexin40 was detected by immunofluorescence in all main components of the atrioventricular conduction system including the atrioventricular node, atrioventricular bundle, and Purkinje fibres. Quantitation revealed that levels of connexin40 immunofluorescence increased along the axis of atrioventricular conduction, rising over 10-fold between atrioventricular node and atrioventricular bundle and a further 10-fold between atrioventricular bundle and Purkinje fibres. Connexin40 and connexin43, the principal gap-junctional protein of the mammalian heart, were co-localised within atrioventricular nodal tissues and Purkinje fibres. By applying a novel photobleach/double-labelling protocol, it was demonstrated that connexin40 and connexin43 are co-localised in precisely the same Purkinje fibre myocytes. A model, integrating data on the spatial distribution and relative abundance of connexin40 and connexin43 in the heart, proposes how myocyte-type-specific patterns of connexin isform expression account for the electrical continuity of cardiac atrioventricular conduction.

Sign in / Sign up

Export Citation Format

Share Document