prevertebral ganglia
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Author(s):  
Hayden Torres ◽  
Clara Huesing ◽  
David H. Burk ◽  
Adrien JR Molinas ◽  
Winfried Neuhuber ◽  
...  

The sympathetic nervous system (SNS) plays a crucial role in the regulation of renal and hepatic functions. While sympathetic nerves to the kidney and liver have been identified in many species; specific details are lacking in the mouse. In the absence of detailed information of sympathetic prevertebral innervation of specific organs, selective manipulation of a specific function will remain challenging. Despite providing major postganglionic inputs to abdominal organs limited data are available about the mouse celiac-superior mesenteric complex. We used tyrosine hydroxylase (TH) and dopamine beta hydroxylase (DbH) reporter mice to visualize abdominal prevertebral ganglia. We found that both the TH and DbH reporter mice are useful models for identification of ganglia and nerve bundles. We further tested if the celiac-superior mesenteric complex provides differential inputs to the mouse kidney and liver. The retrograde viral tracer, pseudorabies virus 152 was injected into the cortex of the left kidney or the main lobe of the liver to identify kidney- and liver-projecting neurons in the celiac-superior mesenteric complex. iDISCO immunostaining and tissue clearing were used to visualize unprecedented anatomical detail of kidney- and liver-related postganglionic neurons in the celiac-superior mesenteric complex, aortico-renal and suprarenal ganglia in comparison to TH positive neurons. Kidney-projecting neurons were restricted to the suprarenal and aortico-renal ganglia, while only sparse labeling was observed in the celiac-superior mesenteric complex. In contrast, liver-projecting postganglionic neurons were observed in the celiac-superior mesenteric complex, aortico-renal and suprarenal ganglia suggesting spatial separation between the sympathetic innervation of the mouse kidney and liver.


2014 ◽  
Vol 40 (1) ◽  
pp. 76-84 ◽  
Author(s):  
Petr M. Masliukov ◽  
Andrey I. Emanuilov ◽  
Konstantin Moiseev ◽  
Alexandr D. Nozdrachev ◽  
Svetlana Dobrotvorskaya ◽  
...  

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
Mohammad Esfahanian ◽  
Amit H Shah ◽  
Xian Cao ◽  
David L Kreulen

Gut ◽  
2002 ◽  
Vol 51 (Supplement 1) ◽  
pp. i6-i10 ◽  
Author(s):  
J H Szurszewski ◽  
L G Ermilov ◽  
S M Miller
Keyword(s):  

2001 ◽  
Vol 120 (5) ◽  
pp. A83-A83
Author(s):  
S MILLER ◽  
L SHA ◽  
L ERMILOV ◽  
H DRUMMOND ◽  
M WELSH ◽  
...  

2001 ◽  
Vol 120 (5) ◽  
pp. A83
Author(s):  
Steven M. Miller ◽  
Lei Sha ◽  
Leonid G. Ermilov ◽  
Heather A. Drummond ◽  
Michael J. Welsh ◽  
...  

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