Increased sister chromatid exchanges in epileptic children during long-term therapy with phenytoin

1982 ◽  
Vol 61 (1) ◽  
pp. 71-72 ◽  
Author(s):  
M. Habedank ◽  
K. -J. E�er ◽  
D. Br�ll ◽  
F. Kotlarek ◽  
C. Stumpf
Keyword(s):  
Sister Chromatid ◽  
Sister Chromatid Exchanges ◽  
Term Therapy ◽  
Epileptic Children ◽  
Long Term Therapy ◽  
Chromatid Exchanges

Effect of Long-Term Therapy with Sodium Valproate on Nail and Serum Trace Element Status in Epileptic Children

2004 ◽  
Vol 102 (1-3) ◽  
pp. 001-010 ◽  
Author(s):  
Ferah Armutcu ◽  
Elif Ozerol ◽  
Ahmet Gurel ◽  
Mehmet Kanter ◽  
Huseyin Vural ◽  
...  
Keyword(s):  
Trace Element ◽  
Sodium Valproate ◽  
Term Therapy ◽  
Trace Element Status ◽  
Epileptic Children ◽  
Serum Trace Element ◽  
Long Term Therapy

scholarly journals Serum levels of zinc and copper in epileptic children during long-term therapy with anticonvulsants

Neurosciences ◽  
2015 ◽  
Vol 20 (4) ◽  
pp. 341-345 ◽  
Author(s):  
Mohamed Talat ◽  
Anwar Ahmed ◽  
Lamia Mohammed
Keyword(s):  
Serum Levels ◽  
Term Therapy ◽  
Epileptic Children ◽  
Long Term Therapy

scholarly journals Association of Polymorphisms of Phase I Metabolizing Genes with Sister Chromatid Exchanges in Occupational Workers Exposed to Toluene Used in Paint Thinners

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Kanu Priya ◽  
Anita Yadav ◽  
Neeraj Kumar ◽  
Sachin Gulati ◽  
Neeraj Aggarwal ◽  
...  
Keyword(s):  
Phase I ◽  
Sister Chromatid ◽  
Sister Chromatid Exchange ◽  
Sister Chromatid Exchanges ◽  
Confounding Factors ◽  
Genetic Damage ◽  
Blood Samples ◽  
Genotoxic Risk ◽  
Chromatid Exchanges

This study investigated genetic damage in paint workers mainly exposed to toluene as it is a major solvent used in paint thinners. Sister chromatid exchange (SCE) assay was used as biomarker of genotoxicity. Blood samples were collected from 30 paint workers and 30 control subjects matched with respect to age and other confounding factors except for exposure to toluene. SCE frequency was found to be significantly higher in paint workers (4.81±0.92) as compared to control individuals (1.73±0.54) (p<0.05). We also investigated influence of polymorphisms of CYP2E1 and CYP1A1m2 genes on SCE frequency. Our results showed that there was significant increase in frequencies of SCE among the mutant genotypes of CYP2E1 and CYP1A1m2 as compared to wild genotypes. Our study indicated that long term exposure of toluene can increase genotoxic risk in paint workers.

The effect of long-term therapy with sodium valproate on oxidant/antioxidant status in epileptic children

2003 ◽  
Vol 32 (2) ◽  
pp. 115-122
Author(s):  
Elif Ozerol ◽  
Mehmet Aslan ◽  
Ecir Ali Cakmak ◽  
Mukaddes Gulec ◽  
Cengiz Yakinci ◽  
...  
Keyword(s):  
Sodium Valproate ◽  
Antioxidant Status ◽  
Term Therapy ◽  
Epileptic Children ◽  
Long Term Therapy

Chromosomal investigations in epileptic children during long-term therapy with phenytoin or primidone

1981 ◽  
Vol 56 (3) ◽  
pp. 345-348 ◽  
Author(s):  
K. J. Eßer ◽  
F. Kotlarek ◽  
M. Habedank ◽  
Ute Mühler ◽  
E. Mühler
Keyword(s):  
Term Therapy ◽  
Epileptic Children ◽  
Long Term Therapy
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