Cytogenetic analysis of the X chromosome region 2B3-4 ? 2B11 of Drosophila melanogaster

Chromosoma ◽  
1982 ◽  
Vol 86 (2) ◽  
pp. 251-263 ◽  
Author(s):  
Elena S. Belyaeva ◽  
Igor F. Zhimulev
Chromosoma ◽  
1985 ◽  
Vol 92 (5) ◽  
pp. 351-356 ◽  
Author(s):  
Z. M. Biyasheva ◽  
E. S. Belyaeva ◽  
I. F. Zhimulev

Chromosoma ◽  
1980 ◽  
Vol 81 (2) ◽  
pp. 281-306 ◽  
Author(s):  
E. S. Belyaeva ◽  
M. G. Aizenzon ◽  
V. F. Semeshin ◽  
I. I. Kiss ◽  
K. Koczka ◽  
...  

Chromosoma ◽  
1981 ◽  
Vol 84 (2) ◽  
pp. 207-219 ◽  
Author(s):  
E. S. Belyaeva ◽  
I. E. Vlassova ◽  
Z. M. Biyasheva ◽  
V. T. Kakpakov ◽  
G. Richards ◽  
...  

Chromosoma ◽  
1982 ◽  
Vol 85 (5) ◽  
pp. 659-672 ◽  
Author(s):  
I. F. Zhimulev ◽  
I. E. Vlassova ◽  
E. S. Belyaeva

Genetics ◽  
1993 ◽  
Vol 134 (1) ◽  
pp. 243-249 ◽  
Author(s):  
D R Dorer ◽  
M A Cadden ◽  
B Gordesky-Gold ◽  
G Harries ◽  
A C Christensen

Abstract One of the most extreme examples of gene dosage sensitivity is the Triplo-lethal locus (Tpl) on the third chromosome of Drosophila melanogaster, which is lethal when present in either one or three copies. Increased dosage of an unlinked locus, Isis, suppresses the triplo-lethal phenotype of Tpl, but not the haplo-lethal phenotype. We have mapped Isis to the X chromosome region 7E3-8A5, and shown that the suppression is a gene dosage effect. Altered dosage of Isis in the presence of two copies of Tpl has no obvious effects. By examining the interactions between Isis dosage and Tpl we suggest that Isis does not directly repress Tpl expression, but acts downstream on the triplo-lethal phenotype of Tpl.


Chromosoma ◽  
1987 ◽  
Vol 95 (4) ◽  
pp. 295-310 ◽  
Author(s):  
E. S. Belyaeva ◽  
M. O. Protopopov ◽  
E. M. Baricheva ◽  
V. F. Semeshin ◽  
M. L. Izquierdo ◽  
...  

Genetics ◽  
1980 ◽  
Vol 94 (1) ◽  
pp. 115-133 ◽  
Author(s):  
Thomas C Kaufman ◽  
Ricki Lewis ◽  
Barbara Wakimoto

ABSTRACT Cytogenetic evidence is presented demonstrating that the 84A-B interval in the proximal portion of the right arm of chromosome 3 is the residence of a homoeotic gene complex similar to the bithorax locus. This complex, originally defined by the Antennapedia (A n t p) mutation, controls segmentation in the anterior portion of the organism. Different lesions within this complex homoeotically transform portions OI the prothorax, proboscis, antenna and eye and present clear analogies to similar lesions within the bithorax locus.


Genetics ◽  
1997 ◽  
Vol 147 (3) ◽  
pp. 1303-1316
Author(s):  
Michael W Nachman

Introns of four X-linked genes (Hprt, Plp, Glra2, and Amg) were sequenced to provide an estimate of nucleotide diversity at nuclear genes within the house mouse and to test the neutral prediction that the ratio of intraspecific polymorphism to interspecific divergence is the same for different loci. Hprt and Plp lie in a region of the X chromosome that experiences relatively low recombination rates, while Glra2 and Amg lie near the telomere of the X chromosome, a region that experiences higher recombination rates. A total of 6022 bases were sequenced in each of 10 Mus domesticus and one M. caroli. Average nucleotide diversity (π) for introns within M. domesticus was quite low (π = 0.078%). However, there was substantial variation in the level of heterozygosity among loci. The two telomeric loci, Glra2 and Amg, had higher ratios of polymorphism to divergence than the two loci experiencing lower recombination rates. These results are consistent with the hypothesis that heterozygosity is reduced in regions with lower rates of recombination, although sampling of additional genes is needed to establish whether there is a general correlation between heterozygosity and recombination rate as in Drosophila melanogaster.


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