Cytogenetic analysis of the 2B3-4-2B11 Region of the X-chromosome of Drosophila melanogaster

Chromosoma ◽  
1980 ◽  
Vol 81 (2) ◽  
pp. 281-306 ◽  
Author(s):  
E. S. Belyaeva ◽  
M. G. Aizenzon ◽  
V. F. Semeshin ◽  
I. I. Kiss ◽  
K. Koczka ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
X Chromosome ◽  
Cytogenetic Analysis

Cytogenetic analysis of the 2B3-4-2B11 Region of the X chromosome of Drosophila melanogaster

Chromosoma ◽  
1981 ◽  
Vol 84 (2) ◽  
pp. 207-219 ◽  
Author(s):  
E. S. Belyaeva ◽  
I. E. Vlassova ◽  
Z. M. Biyasheva ◽  
V. T. Kakpakov ◽  
G. Richards ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
X Chromosome ◽  
Cytogenetic Analysis

Cytogenetic analysis of the 2B3-4 ? 2B11 region of the X chromosome of Drosophila melanogaster

Chromosoma ◽  
1982 ◽  
Vol 85 (5) ◽  
pp. 659-672 ◽  
Author(s):  
I. F. Zhimulev ◽  
I. E. Vlassova ◽  
E. S. Belyaeva
Keyword(s):  
Drosophila Melanogaster ◽  
X Chromosome ◽  
Cytogenetic Analysis

Cytogenetic analysis of the X-chromosome region 2B1-2-2B9-10 of Drosophila melanogaster

Chromosoma ◽  
1985 ◽  
Vol 92 (5) ◽  
pp. 351-356 ◽  
Author(s):  
Z. M. Biyasheva ◽  
E. S. Belyaeva ◽  
I. F. Zhimulev
Keyword(s):  
Drosophila Melanogaster ◽  
X Chromosome ◽  
Cytogenetic Analysis ◽  
Chromosome Region

Cytogenetic analysis of region 2B3-4-2B11 of the X-chromosome of Drosophila melanogaster

Chromosoma ◽  
1987 ◽  
Vol 95 (4) ◽  
pp. 295-310 ◽  
Author(s):  
E. S. Belyaeva ◽  
M. O. Protopopov ◽  
E. M. Baricheva ◽  
V. F. Semeshin ◽  
M. L. Izquierdo ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
X Chromosome ◽  
Cytogenetic Analysis

scholarly journals CYTOGENETIC ANALYSIS OF CHROMOSOME 3 IN DROSOPHILA MELANOGASTER: THE HOMOEOTIC GENE COMPLEX IN POLYTENE CHROMOSOME INTERVAL 84A-B

Genetics ◽  
1980 ◽  
Vol 94 (1) ◽  
pp. 115-133 ◽  
Author(s):  
Thomas C Kaufman ◽  
Ricki Lewis ◽  
Barbara Wakimoto
Keyword(s):  
Drosophila Melanogaster ◽  
Polytene Chromosome ◽  
Cytogenetic Analysis ◽  
Proximal Portion ◽  
Chromosome 3 ◽  
Gene Complex ◽  
Anterior Portion ◽  
Cytogenetic Evidence ◽  
The Right

ABSTRACT Cytogenetic evidence is presented demonstrating that the 84A-B interval in the proximal portion of the right arm of chromosome 3 is the residence of a homoeotic gene complex similar to the bithorax locus. This complex, originally defined by the Antennapedia (A n t p) mutation, controls segmentation in the anterior portion of the organism. Different lesions within this complex homoeotically transform portions OI the prothorax, proboscis, antenna and eye and present clear analogies to similar lesions within the bithorax locus.

scholarly journals Patterns of DNA Variability at X-Linked Loci in Mus domesticus

Genetics ◽  
1997 ◽  
Vol 147 (3) ◽  
pp. 1303-1316
Author(s):  
Michael W Nachman
Keyword(s):  
Drosophila Melanogaster ◽  
X Chromosome ◽  
House Mouse ◽  
Recombination Rate ◽  
Nucleotide Diversity ◽  
Mus Domesticus ◽  
Substantial Variation ◽  
Intraspecific Polymorphism ◽  
Recombination Rates ◽  
Interspecific Divergence

Introns of four X-linked genes (Hprt, Plp, Glra2, and Amg) were sequenced to provide an estimate of nucleotide diversity at nuclear genes within the house mouse and to test the neutral prediction that the ratio of intraspecific polymorphism to interspecific divergence is the same for different loci. Hprt and Plp lie in a region of the X chromosome that experiences relatively low recombination rates, while Glra2 and Amg lie near the telomere of the X chromosome, a region that experiences higher recombination rates. A total of 6022 bases were sequenced in each of 10 Mus domesticus and one M. caroli. Average nucleotide diversity (π) for introns within M. domesticus was quite low (π = 0.078%). However, there was substantial variation in the level of heterozygosity among loci. The two telomeric loci, Glra2 and Amg, had higher ratios of polymorphism to divergence than the two loci experiencing lower recombination rates. These results are consistent with the hypothesis that heterozygosity is reduced in regions with lower rates of recombination, although sampling of additional genes is needed to establish whether there is a general correlation between heterozygosity and recombination rate as in Drosophila melanogaster.

scholarly journals SITE-SPECIFIC INSTABILITY IN DROSOPHILA MELANOGASTER: EVIDENCE FOR TRANSPOSITION OF DESTABILIZING ELEMENT

Genetics ◽  
1982 ◽  
Vol 101 (3-4) ◽  
pp. 461-476
Author(s):  
Todd R Laverty ◽  
J K Lim
Keyword(s):  
Drosophila Melanogaster ◽  
X Chromosome ◽  
Lethal Mutation ◽  
Chromosome Rearrangements ◽  
Chromosome Break ◽  
Secondary Mutation ◽  
X Chromosomes ◽  
Site Specific ◽  
Normal Sequence ◽  
Lethal Mutations

ABSTRACT In this study, we show that at least one lethal mutation at the 3F-4A region of the X chromosome can generate an array of chromosome rearrangements, all with one chromosome break in the 3F-4A region. The mutation at 3F-4A (secondary mutation) was detected in an X chromosome carrying a reverse mutation of an unstable lethal mutation, which was mapped in the 6F1-2 doublet (primary mutation). The primary lethal mutation at 6F1-2 had occurred in an unstable chromosome (Uc) described previously (Lim 1979). Prior to reversion, the 6F1-2 mutation had generated an array of chromosome rearrangements, all having one break in the 6F1-2 doublet (Lim 1979, 1980). In the X chromosomes carrying the 3F-4A secondary lethal mutation the 6F1-2 doublet was normal and stable, as was the 3F-4A region in the X chromosome carrying the primary lethal mutation. The disappearance of the instability having a set of genetic properties at one region (6F1-2) accompanied by its appearance elsewhere in the chromosome (3F-4A) implies that a transposition of the destabilizing element took place. The mutant at 3F-4A and other secondary mutants exhibited all but one (reinversion of an inversion to the normal sequence) of the eight properties of the primary lethal mutations. These observations support the view that a transposable destabilizing element is responsible for the hypermutability observed in the unstable chromosome and its derivaties.

scholarly journals Hybrid dysgenesis-induced quantitative variation on the X chromosome of Drosophila melanogaster.

Genetics ◽  
1990 ◽  
Vol 124 (3) ◽  
pp. 627-636
Author(s):  
C Q Lai ◽  
T F Mackay
Keyword(s):  
Drosophila Melanogaster ◽  
X Chromosome ◽  
Quantitative Traits ◽  
Natural Populations ◽  
Quantitative Variation ◽  
Hybrid Dysgenesis ◽  
X Chromosomes ◽  
Bristle Number ◽  
Seven Generations ◽  
Polygenic Variation

Abstract To determine the ability of the P-M hybrid dysgenesis system of Drosophila melanogaster to generate mutations affecting quantitative traits, X chromosome lines were constructed in which replicates of isogenic M and P strain X chromosomes were exposed to a dysgenic cross, a nondysgenic cross, or a control cross, and recovered in common autosomal backgrounds. Mutational heritabilities of abdominal and sternopleural bristle score were in general exceptionally high-of the same magnitude as heritabilities of these traits in natural populations. P strain chromosomes were eight times more mutable than M strain chromosomes, and dysgenic crosses three times more effective than nondysgenic crosses in inducing polygenic variation. However, mutational heritabilities of the bristle traits were appreciable for P strain chromosomes passed through one nondysgenic cross, and for M strain chromosomes backcrossed for seven generations to inbred P strain females, a result consistent with previous observations on mutations affecting quantitative traits arising from nondysgenic crosses. The new variation resulting from one generation of mutagenesis was caused by a few lines with large effects on bristle score, and all mutations reduced bristle number.

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