Excitatory inputs to cerebellar dentate nucleus neurons from the cerebral cortex in the cat

1987 ◽  
Vol 67 (2) ◽  
Author(s):  
Y. Shinoda ◽  
Y. Sugiuchi ◽  
T. Futami
Keyword(s):  
Cerebral Cortex ◽  
Dentate Nucleus ◽  
Cerebellar Dentate Nucleus

Cerebellar dentate nucleus functional connectivity with cerebral cortex in Alzheimer's disease and memory: a seed-based approach

2020 ◽  
Vol 89 ◽  
pp. 32-40 ◽  
Author(s):  
Giusy Olivito ◽  
Laura Serra ◽  
Camillo Marra ◽  
Carlotta Di Domenico ◽  
Carlo Caltagirone ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebral Cortex ◽  
Functional Connectivity ◽  
Dentate Nucleus ◽  
Cerebellar Dentate Nucleus

An Unfolded Map of the Cerebellar Dentate Nucleus and its Projections to the Cerebral Cortex

2003 ◽  
Vol 89 (1) ◽  
pp. 634-639 ◽  
Author(s):  
Richard P. Dum ◽  
Peter L. Strick
Keyword(s):  
Cerebral Cortex ◽  
Dentate Nucleus ◽  
Neurotropic Viruses ◽  
Transneuronal Transport ◽  
Posterior Parietal ◽  
Cerebellar Dentate Nucleus ◽  
Premotor Areas

We have used retrograde transneuronal transport of neurotropic viruses to examine the organization of the projections from the dentate nucleus of the cerebellum to “motor” and “nonmotor” areas of the cerebral cortex. To perform this analysis we created an unfolded map of the dentate. Plotting the results from current and prior experiments on this unfolded map revealed important features about the topography of function in the dentate. We found that the projections to the primary motor and premotor areas of the cerebral cortex originated from dorsal portions of the dentate. In contrast, projections to prefrontal and posterior parietal areas of cortex originated from ventral portions of the dentate. Thus the dentate contains anatomically separate and functionally distinct motor and nonmotor domains.

scholarly journals Organization of Excitatory Inputs from the Cerebral Cortex to the Cerebellar Dentate Nucleus

1993 ◽  
Vol 20 (S3) ◽  
pp. S19-S28 ◽  
Author(s):  
Shinoda Yoshikazu ◽  
Sugiuchi Yuriko ◽  
Futami Takahiro
Keyword(s):  
Cerebral Cortex ◽  
Dentate Nucleus ◽  
Inferior Olive ◽  
Mossy Fibers ◽  
Excitatory Input ◽  
Control Mechanisms ◽  
Pontine Nucleus ◽  
Pericruciate Cortex ◽  
Cerebellar Dentate Nucleus ◽  
Stimulation Of

ABSTRACT:Intracellular recording was made from dentate nucleus neurons (DNNs) in anesthetized cats, to investigate cerebral inputs to DNNs and their responsible pathways. Stimulation of the medial portion of the contralateral pericruciate cortex most effectively produced EPSPs followed by long-lasting IPSPs in DNNs. Stimulation of the pontine nucleus (PN), the nucleus reticularis tegmenti pontis (NRTP) and the inferior olive (IO) produced monosynaptic EPSPs and polysynaptic IPSPs in DNNs. The results indicate that the excitatory input from the cerebral cortex to DNNs is at least partly relayed via the PN, the NRTP and the 10. Intraaxonal injection of HRP visualized the morphology of mossy fibers from the PN to the DN and the cerebellar cortex. The functional significance of the excitatory inputs from the PN and the NRTP to the DN is discussed in relation to the motor control mechanisms of the cerebellum.

Cerebellar Dentate Nucleus in Alzheimer’s Disease with Myoclonus

1999 ◽  
Vol 10 (2) ◽  
pp. 81-88 ◽  
Author(s):  
Yuken Fukutani ◽  
NigelJ. Cairns ◽  
IanP. Everall ◽  
Andrew Chadwick ◽  
Kiminori Isaki ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Dentate Nucleus ◽  
Cerebellar Dentate Nucleus

Frameless Stereotactic Targeting of the Cerebellar Dentate Nucleus in Nonhuman Primates: Translatable Model for the Surgical Delivery of Gene Therapy

2019 ◽  
Vol 97 (5-6) ◽  
pp. 293-302
Author(s):  
Jeremy S. Wetzel ◽  
Nathan Hardcastle ◽  
Muhibullah S. Tora ◽  
Thais Federici ◽  
Stephen Frey ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Nonhuman Primates ◽  
Dentate Nucleus ◽  
Cerebellar Dentate Nucleus

Spinal Projections of the Cat Parvicellular Red Nucleus

2002 ◽  
Vol 87 (1) ◽  
pp. 453-468 ◽  
Author(s):  
Milton Pong ◽  
Kris M. Horn ◽  
Alan R. Gibson
Keyword(s):  
Spinal Cord ◽  
Dentate Nucleus ◽  
Inferior Olive ◽  
Red Nucleus ◽  
Interpositus Nucleus ◽  
Limb Musculature ◽  
Caudal Portion ◽  
Cerebellar Interpositus Nucleus ◽  
Cerebellar Dentate Nucleus ◽  
Rostral Portion

Traditionally, the red nucleus of the cat is divided into two parts: a large-celled, magnocellular, division (RNm) and a small-celled, parvicellular, division (RNp). The RNm projects to the spinal cord and receives input from the cerebellar interpositus nucleus. The RNp projects to the inferior olive and receives input from the cerebellar dentate nucleus. In this report, we reexamine the connections of the red nucleus using the bidirectional tracer wheat germ agglutinin-horseradish peroxidase (WGA-HRP). Our findings demonstrate that the cat RNp has a large caudal and lateral region that projects to contralateral spinal cord and not to the inferior olive. The spinally projecting region of RNp receives input from the dentate nucleus and a lateral segment of anterior interpositus. Cervical projections from the red nucleus show a topography with the rostral portion of RNp favoring upper segments and the caudal portion of RNm favoring lower segments. The results show that dentate output can influence spinal activity without passing through the cerebral cortex. For the control of movements such as reaching and grasping, we suggest that RNp and dentate focus on the control of proximal limb musculature, whereas RNm and the anterior interpositus focus on the control of distal limb musculature. We also suggest that other species are likely to have a small-celled area of red nucleus projecting to the spinal cord.

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