Destruction of Hassall's corpuscles by macrophages in the sheep thymus

1981 ◽  
Vol 217 (1) ◽  
Author(s):  
M. Kotani ◽  
T. Fukumoto ◽  
M.R. Brandon
Keyword(s):  
Sheep Thymus

scholarly journals THE ANTIMYCOBACTERIAL ACTIVITY OF A PEPTIDE PREPARATION DERIVED FROM CALF THYMUS

1954 ◽  
Vol 99 (1) ◽  
pp. 55-63 ◽  
Author(s):  
René J. Dubos ◽  
James G. Hirsch
Keyword(s):  
Culture Medium ◽  
Culture Media ◽  
Antimycobacterial Activity ◽  
Water Soluble ◽  
Enzymatic Hydrolysate ◽  
Calf Thymus ◽  
Water Soluble Substance ◽  
Peptide Preparation ◽  
Sheep Thymus

A stable, water-soluble substance which possesses potent antimycobacterial activity under certain conditions in vitro has been prepared from calf thymus. This substance has been tentatively named thymus peptide. In final concentrations of 1 to 10 µg. per ml. of an albumin medium it inhibits the growth of various strains of mammalian mycobacteria, but manifests only little or no inhibitory activity against a variety of other microbial species. The ability of thymus peptide to inhibit the multiplication of tubercle bacilli diminishes when the inoculum is large, or when the medium is acidic. It is also markedly antagonized by addition of enzymatic hydrolysate of casein or beef heart infusion broth to the culture medium. Thymus peptide does not exert a rapid bactericidal action on tubercle bacilli, but organisms exposed to this compound for longer than 2 weeks could not be made to multiply in ordinary culture media. Substances similar or identical to the thymus peptide preparation could be extracted from calf spleen, sheep thymus, beef lymph nodes, and calf pancreas, but not from calf lung or calf liver.

Cell adhesion molecule expression in the sheep thymus

2001 ◽  
Vol 25 (5-6) ◽  
pp. 519-530 ◽  
Author(s):  
Ting Zhao ◽  
Chufa He ◽  
Mei Su ◽  
Charles A. West ◽  
Scott J. Swanson ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Adhesion Molecule Expression ◽  
Sheep Thymus

scholarly journals Comparative study of the glycosphingolipids of chicken bursa of Fabricius and of chicken, rat and human thymus

1978 ◽  
Vol 173 (2) ◽  
pp. 475-482 ◽  
Author(s):  
R Narasimhan ◽  
R K Murray
Keyword(s):  
Comparative Study ◽  
Complex Mixture ◽  
Young Male ◽  
Complex Mixtures ◽  
Bursa Of Fabricius ◽  
Neutral Glycosphingolipids ◽  
Acetylneuraminic Acid ◽  
Human Thymus ◽  
Forssman Antigen ◽  
Sheep Thymus

1. The glycosphingolipid compositions of the thymus and bursa of Fabricius of young male chickens were compared. The two tissues were found to contain complex mixtures of both neutral glycosphingolipids and gangliosides. Both tissues contained mono-, di-, tri-, tetra- and penta-glycosylceramides; the pentaglycosylceramide displayed a reaction of identity with authentic Forssman antigen when tested against a specific anti-(Forssman antigen) serum. The ganglioside G(m3) containing N-acetylneuraminic acid was the principle ganglioside of both tissues. 2. The thymus contained appreciable amounts of the simple ganglioside N-acetylneuraminylgalactosylceramide, a compound not found in the bursa. The ganglioside G(d3) (disialohaematoside) was detected in both tissues. 3. Rat and human thymus, like sheep thymus (Narasimhan, Hay, Greaves & Murray (1976) Biochim, Biophys. Acta 431, 578-591), both contained a tetraglycosylceramide species as their most complex neutral glycosphingolipid and possessed little or no Forssman antigen. They also contained a complex mixture of gangliosides. 4. The possible significance of these results is briefly discussed.

scholarly journals Changes in the histological structure of the sheep thymus in the age aspect when using biophysical methods

2019 ◽  
pp. 29-32
Author(s):  
M.I. Selionova ◽  
M.А. Afanasyev ◽  
L.N. Skorykh ◽  
O.V. Dilekova ◽  
D.V. Kovalenko ◽  
...  
Keyword(s):  
Histological Structure ◽  
Sheep Thymus

Purification of thymocyte growth peptide (TGP) from sheep thymus. Relationship to FTS/thymulin

1990 ◽  
Vol 10 (4) ◽  
pp. 403-412 ◽  
Author(s):  
Ulf Ernström ◽  
Guro Gafvelin ◽  
Jane-Marie Rudja
Keyword(s):  
Amino Acid ◽  
Amino Acid Composition ◽  
Acid Composition ◽  
Uv Absorbance ◽  
Large N ◽  
Peptide Moiety ◽  
Calf Thymus ◽  
Acidic Peptide ◽  
New Compounds ◽  
Sheep Thymus

Thymocyte growth peptide (TGP) initiates DNA synthesis in immature thymocytes and has previously been characterized as an acidic peptide isolated from calf thymus. We now report the isolation of TGP from sheep thymus and show it to be a nonapeptide with a large N-terminal blocking moiety characterized by high UV absorbance. The amino acid composition is identical to FTS, consisting of 2 Gly, 2 Ser, 2 Glx, 1 Ala, 1 Lys, 1 Asx. In contrast to FTS, TGP is acidic with an apparent isoelectric point of 4.2 and a high UV absorbance at 270–280 nm. Reverse phase chromatography of TGP at an acidic pH results in a change of the molecule and the appearance of two new compounds TGP-A and TGP-B, both with less than 50% of the original TGP activity. Full activity could be restored by the addition of ZnCl2 to TGP-A. Both TGP-A and B have some amino acid composition and high UV absorbance as native TGP. We propose that TGP consists of a non-peptide moiety bound to the N-terminal of the nonapeptide Glu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn and that the active molecule is stabilized by Zn2+.

High Density Tissue Culture on Microporous Membranes Perfused by Blood: Report of a New Bioartificial System

1978 ◽  
Vol 1 (6) ◽  
pp. 280-287 ◽  
Author(s):  
D.C. White ◽  
T. Kolobow ◽  
R.L. Bowman
Keyword(s):  
Tissue Culture ◽  
Culture System ◽  
High Density ◽  
Fetal Sheep ◽  
Arterial Blood ◽  
Density Growth ◽  
Polycarbonate Membranes ◽  
High Density Cell ◽  
Sheep Thymus

A new tissue culture system has been developed to sup-port high density cell growth using the sheep as the host. Cellular nutrition is provided by plasma solutes as they diffuse from arterial blood across microporous polycarbonate membranes into a device attached to an arteriovenous shunt. Culture chambers are constructed with transparent polycarbonate to allow photomicroscopy of the tissue in situ. System performance is demonstrated by the high density growth of fetal sheep thymus allografts and rat soft tissue sarcoma xenografts.

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