Dynamic organization of primary motor cortex output to target muscles in adult rats II. Rapid reorganization following motor nerve lesions

1990 ◽  
Vol 79 (3) ◽  
Author(s):  
J.P. Donoghue ◽  
S. Suner ◽  
J.N. Sanes
1996 ◽  
Vol 203 (3) ◽  
pp. 179-182 ◽  
Author(s):  
Jozsef Toldia ◽  
Rainer Laskawi ◽  
Michael Landgrebe ◽  
Joachim R. Wolff

2013 ◽  
Vol 2013 ◽  
pp. 1-12 ◽  
Author(s):  
Nordeyn Oulad Ben Taib ◽  
Mario Manto

We assessed the effects of anodal/cathodal direct current stimulation (DCS) applied epidurally over the cerebellum. We studied the excitability of both the motor cortex and the anterior horn of the spinal cord in adult rats under continuous anesthesia. We also investigated the effects on the spatial representation of a couple of agonist/antagonist muscles on primary motor cortex. Moreover, we evaluated the effects on the afferent inhibition in a paradigm of conditioned corticomotor responses. Anodal DCS of the cerebellum (1) decreased the excitability of the motor cortex, (2) reduced the excitability ofFwaves, as shown by the decrease of both meanF/meanMratios and persistence ofFwaves, (3) exerted a “smoothing effect” on corticomotor maps, reshaping the representation of muscles on the motor cortex, and (4) enhanced the afferent inhibition of conditioned motor evoked responses. Cathodal DCS of the cerebellum exerted partially reverse effects. DCS of the cerebellum modulates the excitability of both motor cortex and spinal cord at the level of the anterior horn. This is the first demonstration that cerebellar DCS tunes the shape of corticomotor maps. Our findings provide a novel mechanism by which DCS of the cerebellum exerts a remote neuromodulatory effect upon motor cortex.


1997 ◽  
Vol 254 (2) ◽  
pp. 81-85 ◽  
Author(s):  
R. Laskawi ◽  
A. Roblmann ◽  
M. Landgrebe ◽  
J. R. Wolff

1998 ◽  
Vol 38 (5) ◽  
pp. 769
Author(s):  
Ho Kyu Lee ◽  
Jin Suh Kim ◽  
Youn Mee Hwang ◽  
Myung Joon Lee ◽  
Soo Mee Lim ◽  
...  

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