Comments on ‘in vivo selection of human renal carcinoma cells with high metastatic potential in nude mice’

1990 ◽  
Vol 8 (1) ◽  
pp. 103-106 ◽  
Author(s):  
L. Weiss
Keyword(s):  
Nude Mice ◽  
Renal Carcinoma ◽  
Metastatic Potential ◽  
Carcinoma Cells ◽  
High Metastatic Potential ◽  
In Vivo Selection ◽  
Human Renal Carcinoma ◽  
Selection Of ◽  
Renal Carcinoma Cells

Effects of low calcium levels on erythropoietin production by human renal carcinoma cells in culture

1987 ◽  
Vol 253 (6) ◽  
pp. C797-C801 ◽  
Author(s):  
K. Nagakura ◽  
M. Ueno ◽  
J. Brookins ◽  
B. S. Beckman ◽  
J. W. Fisher
Keyword(s):  
Lactate Dehydrogenase ◽  
Culture Medium ◽  
Renal Carcinoma ◽  
Extracellular Calcium ◽  
Carcinoma Cells ◽  
Cells In Culture ◽  
Low Calcium ◽  
Human Renal Carcinoma ◽  
Renal Carcinoma Cells

Recent investigations have shown that calcium entry blockers enhance the effects of hypoxia on erythropoietin (Ep) production in vivo. To determine whether deprivation of calcium increases Ep production and/or release, studies were carried out to determine the effects of low levels of extracellular calcium on Ep (radioimmunoassay) secretion in human renal carcinoma cells in culture. Low extracellular calcium levels (0.3 mM) in culture medium significantly (P less than 0.01) enhanced Ep secretion (64-145% increase per day) by renal carcinoma cells in culture when compared with a concentration of 1.9 mM calcium in the control culture medium (23-68% increase per day) incubated for 24 h or more. A 53% increase per day in Ep secretion was also produced by the calmodulin inhibitor trifluoperazine. To determine whether the effects of low calcium levels on Ep production could be due to nonspecific leakage of large intracellular molecules caused by a permeabilization of the cell membrane, the effect of low calcium levels in the cultures of the renal carcinoma cells on lactate dehydrogenase release into the culture medium was studied. Low calcium concentrations failed to significantly enhance lactate dehydrogenase secretion by the renal carcinoma cells. In conclusion, our results indicate a possible involvement of the calcium ion and calmodulin in the biosynthetic pathway for Ep and that calcium may exert a suppressive effect on Ep production.

Betulinic acid induces apoptosis and inhibits metastasis of human renal carcinoma cells in vitro and in vivo

2018 ◽  
Vol 119 (10) ◽  
pp. 8611-8622 ◽  
Author(s):  
Chunming Yang ◽  
Yan Li ◽  
Liye Fu ◽  
Tao Jiang ◽  
Fandong Meng
Keyword(s):  
Betulinic Acid ◽  
Renal Carcinoma ◽  
Carcinoma Cells ◽  
Human Renal Carcinoma ◽  
Renal Carcinoma Cells

scholarly journals Immune Check Point CD40–CD40L Activates Dendritic and Effector Cells Against Human Renal Carcinoma Cells

2019 ◽  
Vol 39 (9) ◽  
pp. 4643-4652 ◽  
Author(s):  
REGINA M. HILLEBRAND ◽  
ANNABELLE VOGT ◽  
CHRISTIAN P. STRASSBURG ◽  
MARIA A. GONZALEZ-CARMONA ◽  
INGO G.H. SCHMIDT-WOLF
Keyword(s):  
Renal Carcinoma ◽  
Carcinoma Cells ◽  
Check Point ◽  
Effector Cells ◽  
Human Renal Carcinoma ◽  
Renal Carcinoma Cells

Endoplasmic reticulum stress mediates withaferin A-induced apoptosis in human renal carcinoma cells

2011 ◽  
Vol 25 (3) ◽  
pp. 692-698 ◽  
Author(s):  
Min Jung Choi ◽  
Eun Jung Park ◽  
Kyoung Jin Min ◽  
Jong-Wook Park ◽  
Taeg Kyu Kwon
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Renal Carcinoma ◽  
Carcinoma Cells ◽  
Withaferin A ◽  
Induced Apoptosis ◽  
Human Renal Carcinoma ◽  
Renal Carcinoma Cells
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