DNA Major Groove Binders: Triple Helix-Forming Oligonucleotides, Triple Helix-Specific DNA Ligands and Cleaving Agents

2005 ◽  
pp. 109-148 ◽  
Author(s):  
Christophe Escudé ◽  
Jian-Sheng Sun
Keyword(s):  
Triple Helix ◽  
Major Groove ◽  
Groove Binders

A Modular Synthetic Route to Dimeric Calixarenes: A New Family of DNA Major Groove Binders

Synthesis ◽  
2011 ◽  
Vol 2011 (08) ◽  
pp. 1193-1204 ◽  
Author(s):  
T. Schrader ◽  
C. Blecking ◽  
W. Hu ◽  
R. Zadmard ◽  
A. Dasgupta
Keyword(s):  
Major Groove ◽  
Synthetic Route ◽  
New Family ◽  
Groove Binders

Formation of stable DNA triplexes

2011 ◽  
Vol 39 (2) ◽  
pp. 629-634 ◽  
Author(s):  
Keith R. Fox ◽  
Tom Brown
Keyword(s):  
Triple Helix ◽  
Low Ph ◽  
Cross Linking ◽  
Duplex Dna ◽  
Sequence Specificity ◽  
Modified Oligonucleotides ◽  
Major Groove ◽  
Dna Triplexes ◽  
Helix Formation ◽  
Triple Helix Formation

Triple-helical nucleic acids are formed by binding an oligonucleotide within the major groove of duplex DNA. These complexes offer the possibility of designing oligonucleotides which bind to duplex DNA with considerable sequence specificity. However, triple-helix formation with natural nucleotides is limited by (i) the requirement for low pH, (ii) the requirement for homopurine target sequences, and (iii) their relatively low affinity. We have prepared modified oligonucleotides to overcome these limitations, including the addition of positive charges to the sugar and/or base, the inclusion of cytosine analogues, the development of nucleosides for recognition of pyrimidine interruptions and the attachment of one or more cross-linking groups. By these means we are able to generate triplexes which have high affinities at physiological pH at sequences that contain pyrimidine interruptions.

ChemInform Abstract: A Modular Synthetic Route to Dimeric Calixarenes: A New Family of DNA Major Groove Binders.

ChemInform ◽  
2011 ◽  
Vol 42 (30) ◽  
pp. no-no
Author(s):  
C. J. Blecking ◽  
W. Hu ◽  
R. Zadmard ◽  
A. Dasgupta ◽  
T. Schrader
Keyword(s):  
Major Groove ◽  
Synthetic Route ◽  
New Family ◽  
Groove Binders

Dimeric Calixarenes: A New Family of Major-Groove Binders

2012 ◽  
Vol 18 (12) ◽  
pp. 3589-3597 ◽  
Author(s):  
Wenbin Hu ◽  
Caroline Blecking ◽  
Marijeta Kralj ◽  
Lidija Šuman ◽  
Ivo Piantanida ◽  
...  
Keyword(s):  
Major Groove ◽  
New Family ◽  
Groove Binders

Natural product DNA major groove binders

2012 ◽  
Vol 29 (2) ◽  
pp. 134-143 ◽  
Author(s):  
Paris L. Hamilton ◽  
Dev P. Arya
Keyword(s):  
Natural Product ◽  
Major Groove ◽  
Groove Binders
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