Natural product DNA major groove binders

2012 ◽  
Vol 29 (2) ◽  
pp. 134-143 ◽  
Author(s):  
Paris L. Hamilton ◽  
Dev P. Arya
Keyword(s):  
Natural Product ◽  
Major Groove ◽  
Groove Binders

A Modular Synthetic Route to Dimeric Calixarenes: A New Family of DNA Major Groove Binders

Synthesis ◽  
2011 ◽  
Vol 2011 (08) ◽  
pp. 1193-1204 ◽  
Author(s):  
T. Schrader ◽  
C. Blecking ◽  
W. Hu ◽  
R. Zadmard ◽  
A. Dasgupta
Keyword(s):  
Major Groove ◽  
Synthetic Route ◽  
New Family ◽  
Groove Binders

ChemInform Abstract: A Modular Synthetic Route to Dimeric Calixarenes: A New Family of DNA Major Groove Binders.

ChemInform ◽  
2011 ◽  
Vol 42 (30) ◽  
pp. no-no
Author(s):  
C. J. Blecking ◽  
W. Hu ◽  
R. Zadmard ◽  
A. Dasgupta ◽  
T. Schrader
Keyword(s):  
Major Groove ◽  
Synthetic Route ◽  
New Family ◽  
Groove Binders

Dimeric Calixarenes: A New Family of Major-Groove Binders

2012 ◽  
Vol 18 (12) ◽  
pp. 3589-3597 ◽  
Author(s):  
Wenbin Hu ◽  
Caroline Blecking ◽  
Marijeta Kralj ◽  
Lidija Šuman ◽  
Ivo Piantanida ◽  
...  
Keyword(s):  
Major Groove ◽  
New Family ◽  
Groove Binders

scholarly journals Truncated S-MGBs: towards a parasite-specific and low aggregation chemotype

2021 ◽  
Author(s):  
Daniel P. Brooke ◽  
Leah M. C. McGee ◽  
Federica Giordani ◽  
Jasmine M. Cross ◽  
Abedawn I. Khalaf ◽  
...  
Keyword(s):  
Natural Product ◽  
Pyrrole Ring ◽  
Minor Groove ◽  
Design And Synthesis ◽  
Minor Groove Binders ◽  
Groove Binders

This paper describes the design and synthesis of Strathclyde minor groove binders (S-MGBs) that have been truncated by the removal of a pyrrole ring in order to mimic the structure of the natural product, disgocidine.

Synthetic studies toward inducamide C

2021 ◽  
Author(s):  
Ardalan A. Nabi ◽  
Lydia M. Scott ◽  
Daniel P. Furkert ◽  
Jonathan Sperry
Keyword(s):  
Natural Product ◽  
Structural Revision ◽  
Synthetic Studies

The rare benzoxazepine ring in the alkaloid inducamide C is unstable and prone to rearrangement, indicating that structural revision of the natural product may be necessary.

Lessons learned from the optimization of natural product based kinase inhibitors through molecular calculations

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
V Myrianthopoulos ◽  
P Magiatis ◽  
AL Skaltsounis ◽  
L Meijer ◽  
E Mikros
Keyword(s):  
Natural Product ◽  
Kinase Inhibitors ◽  
Lessons Learned ◽  
Molecular Calculations
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