Dental Pulp Stem Cells in Customized 3D Nanofibrous Scaffolds for Regeneration of Peripheral Nervous System

2018 ◽  
pp. 157-166 ◽  
Author(s):  
Siddhartha Das ◽  
Jayesh R. Bellare
Keyword(s):  
Stem Cells ◽  
Nervous System ◽  
Peripheral Nervous System ◽  
Dental Pulp ◽  
Dental Pulp Stem Cells ◽  
Nanofibrous Scaffolds

scholarly journals Towards osteogenic differentiation of human dental pulp stem cells on PCL-PEG-PCL/zeolite nanofibrous scaffolds

2019 ◽  
Vol 47 (1) ◽  
pp. 3431-3437 ◽  
Author(s):  
Mahdieh Alipour ◽  
Marziyeh Aghazadeh ◽  
Abolfazl Akbarzadeh ◽  
Zahra Vafajoo ◽  
Zahra Aghazadeh ◽  
...  
Keyword(s):  
Stem Cells ◽  
Osteogenic Differentiation ◽  
Dental Pulp ◽  
Dental Pulp Stem Cells ◽  
Nanofibrous Scaffolds ◽  
Human Dental Pulp

scholarly journals Concise Review: Dental Pulp Stem Cells: A Novel Cell Therapy for Retinal and Central Nervous System Repair

Stem Cells ◽  
2016 ◽  
Vol 35 (1) ◽  
pp. 61-67 ◽  
Author(s):  
Ben Mead ◽  
Ann Logan ◽  
Martin Berry ◽  
Wendy Leadbeater ◽  
Ben A. Scheven
Keyword(s):  
Stem Cells ◽  
Central Nervous System ◽  
Nervous System ◽  
Cell Therapy ◽  
Dental Pulp ◽  
Dental Pulp Stem Cells ◽  
Concise Review ◽  
Central Nervous System Repair

scholarly journals Potential Roles of Dental Pulp Stem Cells in Neural Regeneration and Repair

2018 ◽  
Vol 2018 ◽  
pp. 1-15 ◽  
Author(s):  
Lihua Luo ◽  
Yan He ◽  
Xiaoyan Wang ◽  
Brian Key ◽  
Bae Hoon Lee ◽  
...  
Keyword(s):  
Stem Cells ◽  
Nervous System ◽  
Neuronal Differentiation ◽  
Dental Pulp ◽  
Dental Pulp Stem Cells ◽  
Neural Regeneration ◽  
Differentiation Potential ◽  
Neural Repair ◽  
Nervous Systems ◽  
Potential Applications

This review summarizes current advances in dental pulp stem cells (DPSCs) and their potential applications in the nervous diseases. Injured adult mammalian nervous system has a limited regenerative capacity due to an insufficient pool of precursor cells in both central and peripheral nervous systems. Nerve growth is also constrained by inhibitory factors (associated with central myelin) and barrier tissues (glial scarring). Stem cells, possessing the capacity of self-renewal and multicellular differentiation, promise new therapeutic strategies for overcoming these impediments to neural regeneration. Dental pulp stem cells (DPSCs) derive from a cranial neural crest lineage, retain a remarkable potential for neuronal differentiation, and additionally express multiple factors that are suitable for neuronal and axonal regeneration. DPSCs can also express immunomodulatory factors that stimulate formation of blood vessels and enhance regeneration and repair of injured nerve. These unique properties together with their ready accessibility make DPSCs an attractive cell source for tissue engineering in injured and diseased nervous systems. In this review, we interrogate the neuronal differentiation potential as well as the neuroprotective, neurotrophic, angiogenic, and immunomodulatory properties of DPSCs and its application in the injured nervous system. Taken together, DPSCs are an ideal stem cell resource for therapeutic approaches to neural repair and regeneration in nerve diseases.

The odontogenic differentiation of human dental pulp stem cells on hydroxyapatite-coated biodegradable nanofibrous scaffolds

2016 ◽  
Vol 65 (14) ◽  
pp. 720-728 ◽  
Author(s):  
Fatemeh Asghari ◽  
Roya Salehi ◽  
Marziyeh Agazadeh ◽  
Effat Alizadeh ◽  
Khosro Adibkia ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dental Pulp ◽  
Dental Pulp Stem Cells ◽  
Odontogenic Differentiation ◽  
Nanofibrous Scaffolds ◽  
Human Dental Pulp

scholarly journals Dental pulp stem cells as a therapy for congenital entero-neuropathy

2021 ◽  
Author(s):  
Koichiro Yoshimaru ◽  
Takayoshi Yamaza ◽  
Shunichi Kajioka ◽  
Soichiro Sonoda ◽  
Yusuke Yanagi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Nervous System ◽  
Neural Crest ◽  
Enteric Nervous System ◽  
Dental Pulp ◽  
Dental Pulp Stem Cells ◽  
Enteric Neurons ◽  
Deciduous Teeth ◽  
Pacemaker Cells ◽  
Distal Intestine

Abstract Hirschsprung’s disease is a congenital entero-neuropathy that causes chronic constipation and intestinal obstruction. New treatments for entero-neuropathy are needed because current surgical strategies have limitations5. Entero-neuropathy results from enteric nervous system dysfunction due to incomplete colonization of the distal intestine by neural crest-derived cells. Impaired cooperation between the enteric nervous system and intestinal pacemaker cells may also contribute to entero-neuropathy. Stem cell therapy to repair these multiple defects represents a novel treatment approach. Dental pulp stem cells derived from deciduous teeth (dDPSCs) are multipotent cranial neural crest-derived cells, but it remains unknown whether dDPSCs have potential as a new therapy for entero-neuropathy. Here we show that intravenous transplantation of dDPSCs into the Japanese Fancy-1 mouse, an established model of hypoganglionosis and entero-neuropathy, improves large intestinal structure and function and prolongs survival. Intravenously injected dDPSCs migrate to affected regions of the intestine through interactions between stromal cell-derived factor-1α and C-X-C chemokine receptor type-4. Transplanted dDPSCs differentiate into both pacemaker cells and enteric neurons in the proximal colon to improve electrical and peristaltic activity. Our findings indicate that transplanted dDPSCs can differentiate into different cell types to correct entero-neuropathy-associated defects.

Tranylcypromine Attenuates Senescence in Dental Pulp Stem Cells

2017 ◽  
Vol 14 (7) ◽  
Author(s):  
Junjun Liu ◽  
Zhi Liu ◽  
Chunyan Wang ◽  
Fang Yu ◽  
Wenping Cai ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dental Pulp ◽  
Dental Pulp Stem Cells
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